Polyphenols: Potential Applications in Cancer Therapy DOI Open Access
María Oriol‐Caballo, Paz Moreno-Murciano, Rafael López‐Blanch

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Polyphenols (PFs) are compounds found in fruits and vegetables, known for their health-related benefits, mainly including antioxidant, antiinflammatory, anticancer properties. However, efficacy is limited by poor bioavailability due to issues like low solubility, rapid metabolism, extensive excretion. Thus, research has focused on improving delivery systems, such as, example, nanoparticles, hydrogels, cocrystals, or conjugation with carrier molecules, which may protect PFs from degradation, improve and/or facilitate targeted cancer cells. promising modulating cancer-related pathways cell proliferation death, metastatic invasion, though translation patients hindered complex mechanisms. This review analyzes factors that affect PF bioavailability, evidences of vivo effects animal models mechanisms, results clinical trials, strategies enhance bioavailability. The idea need directly interact the challenged. Future aims optimize combine standard treatments, explore epigenetic effects, modulation tumor microenvironment, interactions gut microbiota. Advances personalized medicine structural modifications stability absorption could further potential. Despite challenges, remain a avenue complementary oncotherapy solutions.

Language: Английский

PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids DOI
Ru Jia,

Shiyun Shao,

Ping Zhang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155795 - 155795

Published: June 3, 2024

Language: Английский

Citations

7
Role of Trimethylamine N-Oxide in Heart Failure DOI Creative Commons

Lele Jing,

Honghong Zhang,

Qiannan Xiang

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(7)

Published: July 2, 2024

Heart failure (HF) is a clinical syndrome characterizing by typical physical signs and symptomatology resulting from reduced cardiac output and/or intracardiac pressure at rest or under stress due to structural functional abnormalities of the heart. HF often final stage all cardiovascular diseases significant risk factor for sudden arrest, death, liver kidney failure. Current pharmacological treatments can only slow progression recurrence HF. With advancing research into gut microbiome its metabolites, one such trimethylamine N-oxide (TMAO)—has been implicated in advancement correlated with poor prognosis patients However, precise role TMAO has not yet clarified. This review highlights concludes available evidence potential mechanisms associated HF, hope contributing new insights diagnosis prevention

Language: Английский

Citations

7
Short-chain fatty acid on blood-brain barrier and glial function in ischemic stroke DOI
Khiany Mathias, Richard Simon Machado, Solange Stork

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122979 - 122979

Published: Aug. 13, 2024

Language: Английский

Citations

7
Microbial metabolites affect tumor progression, immunity and therapy prediction by reshaping the tumor microenvironment (Review) DOI Creative Commons
Yuhang Zhou, Wenjie Han,

Yun Feng

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 65(1)

Published: June 6, 2024

Several studies have indicated that the gut microbiome and tumor microbiota may affect tumors. Emerging metabolomics research illustrates need to examine variations in microbial metabolite composition between patients with cancer healthy individuals. Microbial metabolites can impact progression of tumors immune response by influencing a number mechanisms, including modulation system, or immune‑related signaling pathways, epigenetic modification proteins DNA damage. also alleviate side effects drug resistance during chemotherapy immunotherapy, while effectively activating system exert immunotherapy. Nevertheless, on immunity be both beneficial harmful, potentially influenced concentration specific type. The present review summarizes roles various different solid tumors, alongside their influence treatment. Additionally, clinical trials evaluating therapeutic related microbes been listed. In summary, studying metabolites, which play crucial role interaction could lead identification new supplementary treatments for cancer. This has potential improve effectiveness treatment enhance patient prognosis.

Language: Английский

Citations

6
Bacteroidetes promotes esophageal squamous carcinoma invasion and metastasis through LPS-mediated TLR4/Myd88/NF-κB pathway and inflammatory changes DOI Creative Commons
Zhongbing Wu, Jianxin Guo, Zhenhuan Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 4, 2024

Abstract Gut microbiota plays a crucial role in gastrointestinal tumors. Additionally, gut microbes influence the progression of esophageal cancer. However, major bacterial genera that affect invasion and metastasis cancer remain unknown, underlying mechanisms unclear. Here, we investigated flora metabolites patients with squamous cell carcinoma found abundant Bacteroides increased secretion entry surface antigen lipopolysaccharide (LPS) into blood, causing inflammatory changes body. We confirmed these results mouse model 4NQO-induced situ further identified epithelial–mesenchymal transition (EMT) occurrence TLR4/Myd88/NF-κB pathway activation vitro experiments revealed LPS from fragile promoted proliferation, migration, invasion, induced EMT by activating pathway. These reveal are closely associated through higher response level signaling both common to inflammation tumors LPS, providing new biological target for prevention or treatment.

Language: Английский

Citations

5
Effects of traditional Chinese medicine polysaccharides on chronic diseases by modulating gut microbiota: A review DOI
Xinyu Li, Rixiang Zhu, Qian Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136691 - 136691

Published: Oct. 1, 2024

Language: Английский

Citations

5
The Role of Short-Chain Fatty Acids, Particularly Butyrate, in Oncological Immunotherapy with Checkpoint Inhibitors: The Effectiveness of Complementary Treatment with Clostridium butyricum 588 DOI Creative Commons

Massimiliano Cazzaniga,

Marco Cardinali, Francesco Di Pierro

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1235 - 1235

Published: June 19, 2024

The discovery of immune checkpoints (CTLA-4, PD-1, and PD-L1) their impact on the prognosis oncological diseases have paved way for development revolutionary treatments. These treatments do not combat tumors with drugs “against” cancer cells but rather support enhance ability system to respond directly tumor growth by attacking lymphocytes. It has now been widely demonstrated that presence an adequate response, essentially represented number TILs (tumor-infiltrating lymphocytes) present in mass decisively influences response disease. Therefore, immunotherapy is based cannot be carried out without increase lymphocytic at site, thereby limiting nullifying certain evasion mechanisms, particularly those expressed activity (under positive physiological conditions) restrain against transformed cells. Immunotherapy experimental phase decades, its excellent results made it a cornerstone many pathologies, especially when combined chemotherapy radiotherapy. Despite these successes, significant patients (approximately 50%) treatment or develop resistance early on. microbiota, composition, our modulate can treatments, reducing side effects increasing sensitivity effectiveness. Numerous studies published high-ranking journals confirm microbial balance, bacteria capable producing short-chain fatty acids (SCFAs), butyrate, essential only chemoradiotherapy also better and, therefore, prognosis. This opens up possibility favorable modulation microbiota could become complementary standard therapies. brief review aims highlight key aspects using precision probiotics, such as Clostridium butyricum, produce butyrate improve checkpoint thus, diseases.

Language: Английский

Citations

4
Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development DOI Creative Commons
Shahin Javanmard, Kayhan Ertürk

Academia molecular biology and genomics., Journal Year: 2025, Volume and Issue: 2(2)

Published: April 1, 2025

This review examines the role of gut microbiota in activation Wnt/β-catenin signaling pathway and its impact on cancer progression via YAP/TAZ activation. Yes-associated protein, YAP, is a transcriptional coactivator involved regulating gene expression cell proliferation by interacting with TEA domain (TEAD) transcription factor Hippo pathway. The an evolutionarily conserved that important for development tissue homeostasis but was described as driving oncogenic processes through activity. In this regard, metabolites drove tumor activating onto increased evidence. discusses recent studies modulation effect further pursues effects treatment prevention.

Language: Английский

Citations

0
Molecular Mechanisms of Dietary Compounds in Cancer Stem Cells from Solid Tumors: Insights into Colorectal, Breast, and Prostate Cancer DOI Open Access
Alexandru Filippi, Teodora Deculescu-Ioniță, Ariana Hudiță

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 631 - 631

Published: Jan. 13, 2025

Cancer stem cells (CSC) are known to be the main source of tumor relapse, metastasis, or multidrug resistance and mechanisms counteract eradicate them their activity remain elusive. There different hypotheses that claim origin CSC might in regular (SC) and, due accumulation mutations, these normal become malignant, any malignant cell that, under certain environmental circumstances, acquires all qualities CSC. Multiple studies indicate lifestyle diet represent a wellbeing can prevent ameliorate phenotype In this review, after brief introduction SC CSC, we analyze effects phenolic non-phenolic dietary compounds highlight molecular shown link diets activation colon, breast, prostate cancer. We focus analysis on specific markers such as sphere formation, CD surface markers, epithelial–mesenchymal transition (EMT), Oct4, Nanog, Sox2, aldehyde dehydrogenase 1 (ALDH1) major signaling pathways PI3K/Akt/mTOR, NF-κB, Notch, Hedgehog, Wnt/β-catenin conclusion, better understanding how bioactive our influence dynamics raise valuable awareness towards reducing cancer risk.

Language: Английский

Citations

0
Gut microbiota, immune cell, colorectal cancer association mediators: a Mendelian randomization study DOI Creative Commons
Yuegang Li, Meng Zhuang,

Shiwen Mei

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 4, 2025

There have been previously reported associations between the gut microbiota, immune cells, and colorectal cancer; however, specific mechanisms underlying these relationships remain largely unexplored require further research. Therefore, in this study, we aimed to unravel interactions cancer. The analysis used genome-wide association study (GWAS) data encompassing 207 microbial taxa 205 functional pathways on 731 cell phenotypes. Colorectal cancer 6 581 cases 463 421 controls were sourced from Integrative Epidemiology Unit Open GWAS Project. Univariate inverse-variance weighted Mendelian randomization was identify associated with Mediation mediating role of cells link bacteria revealed that several Actinobacteria Firmicutes phyla significantly Coriobacteriaceae (odds ratio [OR]: 0.84, 95% confidence interval [CI]: 0.72-0.97), Sutterellaceae (OR: 0.88, CI: 0.78-0.99), Eggerthella 0.91, 0.84-0.99), Coriobacteriales Collinsella aerofaciens 0.85, 0.74-0.99), Ruminococcus bromii 0.83-0.99) negatively cancer, whereas Lactobacillales 1.11, 1.03-1.20), Veillonella 1.08, 1.01-1.15), Bifidobacterium bifidum 1.05, 1.00-1.09) positively causal pathway CD127 CD28+ CD45RA- CD8br human leukocyte antigen (HLA) DR CD33- HLA DR+, mediated 11.30% - 6.52% effect, respectively, IgD- CD38dim %lymphocyte 14.80% effect. These results highlight potential microbiota phenotypes as novel treatment strategies for

Language: Английский

Citations

0