Ecology Of Freshwater Fish,
Journal Year:
2023,
Volume and Issue:
32(4), P. 677 - 702
Published: March 16, 2023
Abstract
Eurasian
perch
Perca
fluviatilis
has
been
a
popular
model
species
for
decades
in
the
fields
of
aquatic
ecology,
community
dynamics,
behaviour,
physiology
and
ecotoxicology.
Yet,
despite
extensive
research,
progress
integrating
genomic
perspective
into
existing
ecological
knowledge
relatively
modest.
Meanwhile,
emergence
high‐throughput
sequencing
technologies
completely
changed
methods
genetic
variation
assessment
conducting
biodiversity
evolutionary
research.
During
last
5
years,
three
genome
assemblies
P.
have
generated,
allowing
substantial
advancement
our
understanding
interactions
between
processes
at
whole‐genome
level.
We
review
past
progress,
current
status
potential
future
impact
resources
tools
research
focusing
on
utility
recent
assemblies.
Furthermore,
we
demonstrate
power
genome‐wide
approaches
newly
developed
outline
cases
where
genomics
contributed
to
new
knowledge.
explore
how
availability
reference
assembly
enables
efficient
application
various
statistical
tools,
can
provide
novel
insights
resource
polymorphism,
host–parasite
phenotypic
changes
associated
with
climate
change
harvesting‐induced
evolution.
In
summary,
call
increased
integration
perch,
as
well
other
fish
species,
which
is
likely
yield
linking
adaptation
plasticity
ecosystem
functioning
environmental
change.
Biological Conservation,
Journal Year:
2023,
Volume and Issue:
278, P. 109883 - 109883
Published: Jan. 4, 2023
The
conservation
of
biodiversity
from
the
genetic
to
community
levels
is
fundamental
for
continual
provision
ecosystem
services
(ES),
benefits
that
ecosystems
provide
people.
Genetic
and
genomic
diversity
enhance
resilience
populations
communities
underpin
functions
services.
We
show
genomics
applications
are
mostly
limited
flagship
species
their
ES
management
underachieved.
propose
a
framework
on
how
can
guide
sustainable
bridge
this
genomics-ES
'application
gap'.
review
knowledge
in
single
(relatedness,
potentially
adaptive
variants)
or
interacting
(host-microorganism
coevolution,
hybridization)
effective
actions.
These
include
population
supplementation,
assisted
migration
hybridization
promote
climate-adapted
variants
potential,
control
invasives,
delimitation
areas,
provenancing
strategies
restoration,
managing
microbial
function
solving
trade-offs.
Genomics-informed
actions
improved
outcomes
supported
through
synergies
between
scientists
managers
at
local,
regional
international
levels,
development
standardized
workflows,
training
incorporation
local
information.
Such
facilitate
implementation
policies
such
as
UN
2030
goals
EU
Biodiversity
strategy
2030,
support
inclusion
ambitious
new
CBD
post-2020
Global
Framework
hybrids.
Molecular Ecology Resources,
Journal Year:
2024,
Volume and Issue:
24(4)
Published: March 3, 2024
Abstract
Genetic
diversity
is
frequently
described
using
heterozygosity,
particularly
in
a
conservation
context.
Often,
it
estimated
single
nucleotide
polymorphisms
(SNPs);
however,
has
been
shown
that
heterozygosity
values
calculated
from
SNPs
can
be
biased
by
both
study
design
and
filtering
parameters.
Though
solutions
have
proposed
to
address
these
issues,
our
own
work
found
them
inadequate
some
circumstances.
Here,
we
aimed
improve
the
reliability
comparability
of
estimates,
specifically
investigating
how
sample
size
missing
data
thresholds
influenced
calculation
autosomal
(heterozygosity
across
genome,
i.e.
fixed
variable
sites).
We
also
explored
standard
practice
tri‐
tetra‐allelic
site
exclusion
could
bias
estimates
influence
eventual
conclusions
relating
genetic
diversity.
Across
three
distinct
taxa
(a
frog,
Litoria
rubella
;
tree,
Eucalyptus
microcarpa
grasshopper,
Keyacris
scurra
),
meaningfully
affected
thresholds,
partly
due
sites.
These
biases
were
inconsistent
between
species
populations,
with
more
diverse
populations
tending
their
severely
affected,
thus
having
potential
dramatically
alter
interpretations
propose
modified
framework
for
calculating
reduces
improves
utility
as
measure
diversity,
whilst
highlighting
need
existing
population
pipelines
adjusted
such
sites
included
calculations.
Regenerative Therapy,
Journal Year:
2024,
Volume and Issue:
26, P. 260 - 274
Published: June 1, 2024
Chronic
wounds
represent
a
significant
global
burden,
afflicting
millions
with
debilitating
complications.
Despite
standard
care,
impaired
healing
persists
due
to
factors
like
persistent
inflammation
and
tissue
regeneration.
Mesenchymal
stem
cell
(MSC)-derived
extracellular
vesicles
(EVs)
offer
an
innovative
regenerative
medicine
approach,
delivering
cell-derived
therapeutic
cargo
in
engineered
nanoscale
delivery
systems.
This
review
examines
pioneering
bioengineering
strategies
engineer
MSC-EVs
into
precision
nanotherapeutics
for
chronic
wounds.
Emerging
technologies
CRISPR
gene
editing,
microfluidic
manufacturing,
biomimetic
systems
are
highlighted
their
potential
enhance
MSC-EV
targeting,
optimize
enrichment,
ensure
consistent
clinical-grade
production.
However,
key
hurdles
remain,
including
batch
variability,
rigorous
safety
assessment
tumorigenicity,
immunogenicity,
biodistribution
profiling.
Crucially,
collaborative
frameworks
harmonizing
regulatory
science
patient
advocacy
hold
the
expediting
clinical
translation.
By
overcoming
these
challenges,
could
catalyze
new
era
of
off-the-shelf
therapies,
restoring
hope
afflicted
by
non-healing
Molecular Ecology,
Journal Year:
2023,
Volume and Issue:
32(8), P. 1893 - 1907
Published: Jan. 19, 2023
For
small
and
isolated
populations,
the
increased
chance
of
mating
between
related
individuals
can
result
in
a
substantial
reduction
individual
population
fitness.
Despite
increasing
availability
genomic
data
to
measure
inbreeding
accurately
across
genome,
depression
studies
for
threatened
species
are
still
scarce
due
difficulty
measuring
fitness
wild.
Here,
we
investigate
extensively
monitored
Tiritiri
Mātangi
island
Aotearoa
New
Zealand
passerine,
hihi
(Notiomystis
cincta).
First,
using
custom
45
k
single
nucleotide
polymorphism
(SNP)
array,
explore
patterns
by
inferring
homozygous
segments
genome.
Although
all
have
similar
levels
ancient
inbreeding,
highly
inbred
affected
recent
which
probably
be
explained
bottleneck
effects
such
as
habitat
loss
after
European
arrival
their
translocation
1990s.
Second,
on
fitness,
measured
lifetime
reproductive
success,
its
three
components,
juvenile
survival,
adult
annual
survival
363
hihi.
We
find
that
global
significantly
affects
but
none
remaining
traits.
Finally,
employ
genome-wide
association
approach
test
locus-specific
identify
13
SNPs
associated
with
success.
Our
findings
suggest
does
impact
hihi,
at
different
scales
traits,
purging
has
therefore
failed
remove
variants
deleterious
from
this
conservation
concern.
Frontiers in Genetics,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 26, 2022
Massive
defaunation
and
high
extinction
rates
have
become
characteristic
of
the
Anthropocene.
Genetic
effects
population
decline
can
lead
populations
into
an
vortex,
where
declining
show
lower
genetic
fitness,
in
turn
leading
to
still.
The
fitness
a
due
shrinking
gene
pool
is
known
as
erosion.
Three
different
types
erosion
are
highlighted
this
review:
overall
homozygosity,
load
runs
homozygosity
(ROH),
which
indicative
inbreeding.
ability
quantify
could
be
very
helpful
tool
for
conservationists,
it
provide
them
with
objective,
quantifiable
measure
use
assessment
species
at
risk
extinction.
link
between
conservation
status
should
more
apparent.
Currently,
no
clear
correlation
observed
current
However,
quantities
wild
populations,
especially
those
dealing
habitat
fragmentation
decline,
may
early
signs
deteriorating
populations.
Whole
genome
sequencing
data
way
forward
Extra
screening
steps
hybridization
included,
since
they
potentially
great
impact
on
fitness.
This
way,
information
yielded
from
sequence
conservationists
objective
method
complexity
quantification
asks
consensus
bridging
science
its
applications,
remains
challenging.
Animals,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1089 - 1089
Published: March 18, 2023
An
increasing
number
of
aquatic
species
have
been
studied
for
genetic
polymorphism,
which
extends
the
knowledge
on
their
natural
populations.
One
type
high-resolution
molecular
marker
suitable
studying
diversity
large
numbers
individuals
is
single
nucleotide
polymorphism
(SNP).
This
review
an
attempt
to
show
range
applications
SNPs
in
studies
populations
animals.
In
recent
years,
used
analysis
wild
and
enhanced
fish
invertebrate
habitats,
exploited
migratory
oceans,
anadromous
freshwater
demersal
species.
identification
hybrids
environments,
study
consequences
restocking
conservation
purposes
negative
effects
accidentally
escaping
from
culture.
are
very
useful
identifying
genomic
regions
correlated
with
phenotypic
variants
relevant
wildlife
protection,
management
aquaculture.
Experimental
size-selective
catches
created
tanks
caused
evolutionary
changes
life
cycles
fishes.
The
research
results
discussed
clarify
whether
conditions
can
undergo
due
selective
harvesting
targeting
fastest-growing