Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms

Toxicology and Applied Pharmacology, Journal Year: 2023, Volume and Issue: 474, P. 116623 - 116623

Published: July 4, 2023

Language: Английский

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An ultrasensitive LC-MS/MS method for the determination of glyphosate, AMPA and glufosinate in water – analysis of surface and groundwater from a hydrographic basin in the Midwestern region of Brazil

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 875, P. 162499 - 162499

Published: March 4, 2023

Language: Английский

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Effectiveness of lycopene dietary enrichment for growth performance, digestive enzymes, blood health, immunity, and antioxidant status of common carp (Cyprinus carpio) against chronic glyphosate toxicity

Aquaculture, Journal Year: 2024, Volume and Issue: 590, P. 741084 - 741084

Published: May 12, 2024

Language: Английский

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Toxicity of glyphosate and aminomethylphosphonic acid (AMPA) to the early stages of development of Steindachneridion melanodermatum, an endangered endemic species of Southern Brazil

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 102, P. 104234 - 104234

Published: July 20, 2023

Language: Английский

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Effects of Glyphosate or Glyphosate-Based Herbicide during the Zebrafish Life Cycle: A Review Addressing the Mechanisms of Toxicity

Water, Journal Year: 2023, Volume and Issue: 15(12), P. 2276 - 2276

Published: June 17, 2023

Herbicides with glyphosate (GLY) as an active ingredient (a.i.) are increasingly used, and GLY is currently the most used herbicide in world. Consequently, its residues have often been found aquatic ecosystems. Investigating how this substance affects species a priority ecotoxicology research, especially fish, they can absorb concentrate toxins. In sense, critical review was performed, synthesizing data from peer-reviewed bibliography, reporting on toxicity of exposure to pure glyphosate-based herbicides (GBHs), using zebrafish animal model. The concentrations that induced toxic effects highly variable, some exceeding limits determined by regulatory agencies. Globally, relevant reported zebrafish, namely, teratogenic incompatible life, which translates directly into increase mortality. Neurotoxicity, genotoxicity, changes energy metabolism oxidative stress, immune hormonal system dysfunction impact fish reproduction were also described. conclusion, both GBHs may induce damage compromising their survival, reproduction, maintenance. These results be valid applied other

Language: Английский

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Glyphosate- and aminomethylphosphonic acid (AMPA)-induced mortality and residues in juvenile brown trout (Salmo trutta f. fario) exposed at different temperatures

Environmental Sciences Europe, Journal Year: 2024, Volume and Issue: 36(1)

Published: Feb. 16, 2024

Abstract Background Glyphosate is a broad-spectrum, non-selective systemic herbicide with commonly assumed low potential for accumulation in biota. Nevertheless, glyphosate has been shown to bioaccumulate the tissues of several organisms. To understand bioconcentration dynamics fish, brown trout ( Salmo trutta forma fario ) different age were exposed concentrations glyphosate, formulation Roundup® LB Plus, and major transformation product aminomethylphosphonic acid (AMPA) two, three, or four weeks at temperatures laboratory. Mortality rates determined, tissue samples collected end experiment ascertain AMPA residues by liquid chromatography coupled mass spectrometry (LC–MS/MS). Results Brown mortality during exposure was considerably higher 15 °C than 7 °C. Also, significant increase containing muscle, head, backbone, caudal fin increasing observed. Six-month-old fish contained more per kg wet weight after ten-month-old fish. The factors (BCFs) much °C, but both cases decreased concentrations. BCF formulated one parent compound. Approximately 30–42% organ-absorbed remained even when kept clean water lacking test substances three termination exposure. Conclusion Our study demonstrated that there an interaction between ambient temperature terms toxicity. Further it surrounding media lead significantly increased these tissues, although neither nor bioaccumulation animal expected due high solubility this chemical. As consequence, uptake humans through consumption contaminated edible very likely.

Language: Английский

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Comprehensive analysis of Leonotis nepetifolia flower extracts: phytochemical composition and toxicity in zebrafish embryos

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 29, 2025

Leonotis nepetifolia (L.) R. Br., a plant used in traditional medicine, has underexplored phytochemical and toxicological profiles. This study investigates the metabolite profile of L. flowers assesses their toxicity using zebrafish (ZF) embryos. The main active compounds were characterised metabolomic approaches. ZF embryos exposed to methanol extract (CEF), n-hexane (FHF) ethyl acetate (FAF) fractions at different concentrations for 96 h. Toxicological effects assessed including acetylcholinesterase activity, lipid peroxidation, cardiotoxicity, as well hatching delay, developmental defects morphological malformations. Phytochemical analysis revealed diverse metabolites, phytosterols, terpenoids, flavonoids phenylpropanoids. Verbascoside, major compound, was isolated from first time. assessments showed that CEF FAF caused various toxic effects, with showing pronounced embryotoxic teratogenic effects. highlights chemical diversity potential risks nepetifolia, emphasising need thorough evaluations herbal medicines.

Language: Английский

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Environmental concentrations of glyphosate through direct or parental exposure alter nervous system development and reduce the fertility rate in zebrafish

NeuroToxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Glyphosate-based herbicide (GBH) causes damage in embryo-larval stages of zebrafish (Danio rerio)

Neurotoxicology and Teratology, Journal Year: 2022, Volume and Issue: 95, P. 107147 - 107147

Published: Dec. 7, 2022

Language: Английский

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Effects of Glyphosate on Zebrafish (Danio rerio) Developmental Toxicity

Environmental Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Glyphosate has been widely used in agricultural production as a highly effective, low-toxic, broad-spectrum organophosphorus herbicide. However, there controversy about whether it is toxic to the nervous system. In order explore this issue depth, present study analyzed molecular mechanism of action glyphosate from four perspectives, namely, gene regulation, protein expression, morphological changes, and behavioral assessed potential effects on development system zebrafish through establishment model. The results showed that embryos at 6 hpf after fertilization were exposed until 72 120 hpf. After exposure, was found central development-related Elavl3 down-regulated, GAP-43, Neurog1, GFAP up-regulated. expression HuC protein, which maintain neuronal axonal homeostasis, significantly reduced, repair neurological damage inflammation, increased. Under regulation related genes proteins, larvae show abnormal changes during series systems such heart rate slowing, somite shortening, spinal brain malformations. At same time, zebrafish's behavior also changed, with significant decrease its total time share low-speed shift high-speed states, delayed response dark-light environmental stimuli. summary, studies have shown exposure may induce inflammation system, resulting developmental malformations, motor behavior, neurotoxicity. Therefore, possible neurotoxicity risks aquatic animals should not be ignored great concern.

Language: Английский

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