Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1714 - 1714
Published: Aug. 1, 2024
Plastic-based
products
are
ubiquitous
due
to
their
tremendous
utility
in
our
daily
lives.
Nanoplastic
(NP)
and
microplastic
(MP)
pollution
has
become
a
severe
threat
the
planet
is
growing
concern.
It
been
widely
reported
that
polystyrene
(PS)
MPs
severely
toxic
male
reproduction
system,
with
effects
including
decreased
sperm
parameters,
impaired
spermatogenesis,
damaged
testicular
structures.
However,
molecular
mechanisms
for
spermatogenesis
remain
poorly
understood.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
269, P. 115747 - 115747
Published: Dec. 8, 2023
Microplastics
(MPs)
are
global
environmental
pollutants
with
potential
toxicity
concerns,
and
their
effects
on
the
reproductive
system
have
attracted
increasing
attention.
This
study
investigated
interaction
between
MPs
mammalian
biomolecules,
focusing
relationship
testosterone
adsorption
behavior
of
male
health.
The
capacity
different
types
for
was
evaluated
in
vitro
experiments.
Polyamide
(PA)-MPs
exhibited
stronger
adsorption,
while
polymethyl
methacrylate
(PMMA)-MPs
displayed
weakest
adsorption.
Sorption
equilibrium
PA-MPs
achieved
within
6
h,
fitting
Pseudo-2nd-order
model
Langmuir
isotherm.
reproduction
mice
determined
vivo
Male
were
treated
0.1
0.5
mg/d
PA-MPs/PMMA-MPs
by
gavage
once
per
day
28
days.
results
showed
that
only
PA-MP
exposure
induced
decreased
serum
levels,
increased
testicular
levels
compared
to
control,
more
severe
damage
seminiferous
tubule
structure,
sperm
motility
morphology
PMMA-MPs
group.
Meanwhile,
could
reduce
intracellular
nuclear
translocation
androgen
receptor
(AR)
mediated
testosterone,
had
no
impact.
revealed
reduced
bioavailability
caused
quality
decline,
offering
new
insights
into
combined
mechanism
mammals.
Fitoterapia,
Journal Year:
2024,
Volume and Issue:
175, P. 105953 - 105953
Published: April 6, 2024
Structural
and
functional
changes
of
the
intestinal
barrier,
as
a
consequence
number
(epi)genetic
environmental
causes,
have
main
role
in
penetrations
pathogens
toxic
agents,
lead
to
development
inflammation-related
pathological
conditions,
not
only
at
level
GI
tract
but
also
other
extra-digestive
tissues
organs.
Anthocyanins
(ACNs),
subclass
polyphenols
belonging
flavonoid
group,
are
well
known
for
their
health-promoting
properties
widely
distributed
human
diet.
There
is
large
evidence
about
correlation
between
intake
ACN-rich
products
reduction
inflammation
dysfunction.
Our
review
describes
more
recent
advances
knowledge
cellular
molecular
mechanisms
through
which
ACNs
can
modulate
involved
dysfunction
inflammation,
particular
inhibition
NF-κB,
JNK,
MAPK,
STAT3,
TLR4
proinflammatory
pathways,
upregulation
Nrf2
transcription
factor
expression
tight
junction
proteins
mucins.
