Association between serum 25-hydroxyvitamin D and vitamin D dietary supplementation and risk of all-cause and cardiovascular mortality among adults with hypertension

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: March 9, 2024

Abstract Background The relationship between vitamin D status and mortality among adults with hypertension remains unclear. Methods This prospective cohort study involved a sample of 19,500 who participated in the National Health Nutrition Examination Survey (NHANES) from 2001 to 2018. We utilized weighted COX proportional hazard model assess association mortality. statistical calculates ratios (HR) their corresponding 95% confidence intervals (95% CI). Results indicated that lower serum 25(OH)D concentration was associated an increased risk all-cause individuals hypertension. Specially. Those concentrations 25.0 49.9 nmol/L (HR = 1.71, 95%CI 1.22–2.40) less than 1.97, 1.15–3.39) had higher for Individuals took supplements mortality, but not CVD 0.75, 0.54–1.03), compared those did supplement 0.76, 0.61–0.94). Subgroup analysis further revealed supplementation reduced without diabetes 0.65, 0.52–0.81) 0.58–0.97), decreased 0.63, 0.45–0.88) 0.61, 0.40–0.92). Furthermore, higher-dose also greater reduction hypertensive individuals, there potential synergistic effect combining normal-dose calcium supplementation, showing superior on low-dose Conclusions demonstrated significant 25 (OH)D found strong significantly positive correlation or CVD. suggests could potentially be effective strategy reduce this specific group people.

Language: Английский

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Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 32(1), P. 249 - 271

Published: Nov. 13, 2023

Abstract Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose this study was evaluate clinical efficacy vitamin D (VD) in COVID-19 long COVID-19, explain discrepancy outcomes highlight potential impact metformin on VD recent articles. Articles January 2022 August 2023 were selected for review. objective achieved by reviewing, analyzing, discussing articles demonstrating (1) mechanism action (2) observational or randomized trials (RCTs) that support not beneficial effects COVID. (3) genetic non-genetic reasons variation VD. collected electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, Cochrane Database Systematic Reviews. Twenty three studies conducted vitro animal models indicated may act through protecting respiratory system antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate adaptive immune functions up regulation autophagy gene activity. Our review identified 58 met criteria. number publications supporting a activity treating 49 (86%), including 12 meta-analyses. Although total patients included all 14,071,273, role 14,029,411 (99.7%). Collectively, extensive decisive relationship between low levels severity mortality outcomes. Importantly, evidence intervention has demonstrated effectiveness supplements COVID-19. Furthermore, results 4 supported alleviating symptoms disease. However, eight RCTs one meta-analysis contain low-grade against Twenty-five have addressed association VDR DBP polymorphisms treatment failure Impaired signaling underlie variability mechanisms. Interestingly, studies, therapeutic possibly improving AMPK enhancing In conclusion, been significantly strengthened over past 18 months, with several meta-analyses reporting conclusive supplementation highlighting improve sensitivity

Language: Английский

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Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12167 - 12167

Published: July 29, 2023

A variety of phytocompounds contained in medical plants have been used as medication, including Kampo (traditional Japanese) medicine. Phytochemicals are one category the chemical compounds mainly known antioxidants, and recently, their anti-inflammatory effects preventing chronic inflammation received much attention. Here, we present a narrative review health-promotion disease-prevention phytochemicals, polyphenols, latter which abundant onions, oranges, tea, soybeans, turmeric, cacao, grapes, along with synergetic vitamin D. phenomenon currently gaining popularity Japan is finding non-disease conditions, so-called ME-BYO (mibyou) treating them before they develop into illnesses. In addition to lifestyle-related diseases such metabolic syndrome obesity, dementia frailty, commonly found elderly, included underlying conditions. These conditions typically induced by might result multiple organ failure or cancer if left untreated. Maintaining gut microbiota important for suppressing (recently increasing) intestinal disorders upregulating immunity. During COVID-19 pandemic, interest phytochemicals D disease prevention increased, viral bacterial infection lung causes fatal inflammation, induces pulmonary fibrosis. Furthermore, sepsis disorder inducing severe microbes, high mortality ratio non-coronary ICUs. However, antimicrobial peptides (AMPs) working using natural immunity suppress at early stage. The intake enhances effects, upregulates immunity, reduces risk means keeping healthy microbiota. Evidence acquired during pandemic revealed that daily improvement terms diseases, very because increase infectious diseases. This discusses importance lifestyle ME-BYO,

Language: Английский

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Interaction effects between serum 25(OH)D and CRP status on cancer related mortality in adult cancer survivors

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 28, 2025

Vitamin D deficiency and elevated CRP (C-reactive protein) levels are independent indicators of risk for mortality in cancer survivors; however, their combined association with has not been examined. This study included adult survivors from four NHANES cycles (2003-2010), utilizing a multistage survey design. were measured using latex-enhanced turbidimetric assay, serum 25(OH)D assessed RIA LC-MS/MS methods. Mortality data linked the National Death Index up to 2019. The restricted cubic spline model was used explore nonlinear associations mortality. Kaplan-Meier analysis examine survival curve differences. Cox employed assess after adjusting confounding factors, interaction conducted. Of 1619 (56.9% female; weighted age 64.91 ± 0.44 years), 762 deaths recorded during 17-year follow-up. Higher lower associated increased risks all-cause Joint revealed High Low VID group had highest (HR 2.40, 95% CI 1.82-3.17) 5.23, 3.15-8.70) compared group. Additionally, multiplicative between factors on observed (P = 0.049), indicating synergistic effect these two Sex ethnicity subgroup analyses that exhibits mortality, findings consistent those overall population. In survivors, an is vitamin CRP. particular, may impact survivors' related cancers. Consequently, be significantly reduced through use anti-inflammatory medications as well adequate intake D.

Language: Английский

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Association of serum 25-hydroxyvitamin D concentrations with all-cause and cause-specific mortality among individuals with gout and hyperuricemia

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 9, 2024

We aimed to probe the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among patients gout hyperuricemia (HUA).

Language: Английский

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Role of Vitamins in Cardiovascular Health: Know Your Facts-Part 2

Current Vascular Pharmacology, Journal Year: 2023, Volume and Issue: 21(6), P. 399 - 423

Published: Sept. 11, 2023

Abstract: Cardiovascular disease (CVD) is a major cause of morbidity/mortality world-wide, hence preventive interventions are crucial. Observational data showing beneficial CV effects vitamin supplements, promoted by self-proclaimed experts, have led to ~50% Americans using multivitamins; this practice has culminated into multi-billion-dollar business. However, robust evidence lacking, and certain vitamins might incur harm. This two-part review focuses on the attributes or concerns about specific consumption CVD. The for indiscriminate use multivitamins indicates no consistent CVD benefit. Specific and/or combinations suggested, but further supportive needed. Data presented in Part 1 indicated that folic acid B-vitamins may decrease stroke, whereas niacin raise mortality; beta-carotene mediates pro-oxidant effects, which abate benefits from other vitamins. In 2, favor anti-oxidant C anti-atherogenic E, clinical inconsistent. Vitamin D provide protection, conflicting. K appears neutral. Thus, there favorable individual (C/D), randomized/controlled lacking. An important caveat regards potential toxicity increased doses fat-soluble (A/D/E/K). As emphasized 1, benefit subjects who antioxidant-deficient exposed high levels oxidative-stress (e.g., diabetics, smokers, elderly), stressing importance targeting subgroups optimal results. Finally, promoting CV-healthy balanced-diets, we could acquire essential nutrients supplements only indications.

Language: Английский

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Associations of serum albumin and dietary protein intake with all-cause mortality in community-dwelling older adults at risk of sarcopenia

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29734 - e29734

Published: April 1, 2024

Language: Английский

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