Molecular and Cellular Mechanisms Underlying the Cardiac Hypertrophic and Pro-Remodelling Effects of Leptin

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1137 - 1137

Published: Jan. 17, 2024

Since its initial discovery in 1994, the adipokine leptin has received extensive interest as an important satiety factor and regulator of energy expenditure. Although produced primarily by white adipocytes, can be synthesized numerous tissues including those comprising cardiovascular system. Cardiovascular function thus affected locally via autocrine or paracrine manner but also circulating leptin. Leptin exerts effects binding to activating specific receptors, termed ObRs LepRs, belonging Class I cytokine family receptors which six isoforms have been identified. all identical intracellular domains, they differ substantially length terms their extracellular determine ability activate cell signalling pathways. The most these biological is so-called long form (ObRb), possesses complete domain linked full processes. heart shown express ObRb well produce cardiac development hypertrophy likely through a number signaling processes mitochondrial dynamics, demonstrating substantial complex underlying mechanisms. Here, we discuss mechanisms that potentially mediate leptin-induced pathological hypertrophy, may contribute failure.

Language: Английский

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Myocardial ischemia-reperfusion injury: The balance mechanism between mitophagy and NLRP3 inflammasome

Life Sciences, Journal Year: 2024, Volume and Issue: 355, P. 122998 - 122998

Published: Aug. 20, 2024

Language: Английский

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The UCP2/PINK1/LC3B-mediated Mitophagy is involved in the Protection of NRG1 against Myocardial Ischemia/Reperfusion Injury

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103511 - 103511

Published: Jan. 1, 2025

Language: Английский

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Hypoxia Regulates the Proliferation and Apoptosis of Coronary Artery Smooth Muscle Cells Through HIF-1α Mediated Autophagy in Yak

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 256 - 256

Published: Feb. 10, 2025

Cell proliferation and migration mediated by hypoxia-inducible factor-1α (HIF-1α) are important processes of hypoxic cardiac vascular remodeling. HIF-1α also regulates the physiological adaptation coronary artery in yak heart, but potential mechanism remains to be completely elucidated. In this study, increased with age hypoxia time. vitro analysis showed that can promote smooth muscle cells (CASMCs). Meanwhile, plays an role regulation under hypoxia. Autophagy cell participate plateau animals. Here, level autophagy significantly arteries was regulated HIF-1α-mediated addition, could mediate effect on CASMCs. summary, results revealed increase heart thickening increases migration, mainly achieved through hypoxia-mediated HIF-1α-regulated autophagy. These contribute understanding how adapts life a environment.

Language: Английский

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Metabolic Shifts in the Heart of Hypothyroid Mice — Insights from Untargeted Metabolomics

Published: Jan. 1, 2025

Language: Английский

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Progress of nanomaterials in the treatment of ischemic heart disease

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review constructs a dynamic and progressive pathological framework for the development of IHD, from MI to IRI eventually HF, systematically revealing multidimensional therapeutic strategies nanomaterials.

Language: Английский

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Research progress of autophagy in heart failure

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(5), P. 1991 - 2000

Published: Jan. 1, 2024

Heart failure poses a significant threat to global public health within the realm of cardiovascular diseases.Its pathological progression involves various alterations in cardiomyocytes, among which autophagy, crucial intracellular degradation mechanism, plays pivotal role.Autophagy facilitates breakdown damaged organelles and proteins, thereby maintaining cellular homeostasis.In context heart failure, autophagy coexists with apoptosis necrosis, influencing myocardial hypertrophy ventricular remodeling.However, its impact on manifests dual nature: moderate aids cardiac repair, whereas excessive may exacerbate remodeling cell demise.This review delves into fundamental biology elucidating involvement cascade correlation remodeling.Furthermore, an analysis interplay between regulatory factors sheds light potential therapeutic implications prevention management failure.This exploration provides theoretical foundation for novel treatment strategies combating failure.

Language: Английский

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Nur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 23, 2024

Abstract Reproductive aging not only affects the fertility and physical mental health of women but also accelerates process other organs. There is an urgent need newfor novel mechanisms, targets, drugs to break vicious cycle mitochondrial dysfunction, redox imbalance, germ cell apoptosis associated with ovarian aging. Autophagy, recognized as a longevity mechanism, has recently become focal point in anti-aging research. Although mitophagy type autophagy, its role regulatory mechanisms aging, particularly age-related function decline, remain unclear. Nerve growth factor inducible gene B (Nur77) early response that can be stimulated by oxidative stress, DNA damage, metabolism, inflammation. Recent evidence recommends decreased expression Nur77 myocardial fibrosis, renal Parkinson's disease; however, association been studied yet. We herein identified regulator senescence, apoptosis, found overexpression activate mitophagy, improve reduce ultimately enhance reserve aged mice ovaries. Furthermore, we discovered between AKT pathway through String molecular docking analyses. Experimental confirmation revealed AKT/mTOR signaling involved regulation function. In conclusion, our results suggest promising target for preventing treating decline related reproductive

Language: Английский

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Selenomethionine supplementation mitigates fluoride-induced liver apoptosis and inflammatory reactions by blocking Parkin-mediated mitophagy in mice

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175458 - 175458

Published: Aug. 12, 2024

Language: Английский

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Extracellular Vesicle-Derived Non-Coding RNAs: Key Mediators in Remodelling Heart Failure

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 9430 - 9448

Published: Aug. 27, 2024

Heart failure (HF), a syndrome of persistent development cardiac insufficiency due to various heart diseases, is serious and lethal disease for which specific curative therapies are lacking poses severe burden on all aspects global public health. Extracellular vesicles (EVs) essential mediators intercellular interorgan communication, enclosed nanoscale carrying biomolecules such as RNA, DNA, proteins. Recent studies have showed, among other things, that non-coding RNAs (ncRNAs), especially microRNAs (miRNAs), long ncRNAs (lncRNA), circular (circRNAs) can be selectively sorted into EVs modulate the pathophysiological processes HF in recipient cells, acting both healthy diseased hearts, makes them promising targets diagnosis therapy HF. This review aims explore mechanism action EV-ncRNAs failure, with emphasis potential use differentially expressed miRNAs circRNAs biomarkers cardiovascular disease, recent research advances treatment failure. Finally, we focus summarising latest challenges engineering HF, providing novel concepts

Language: Английский

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