The potential role of brain renin‐angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat? DOI Creative Commons
Zainah Al‐Qahtani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(12)

Published: June 1, 2024

Abstract Parkinson disease (PD) is one of the most common neurodegenerative diseases brain. Of note, brain renin‐angiotensin system (RAS) intricate in PD neuropathology through modulation oxidative stress, mitochondrial dysfunction and neuroinflammation. Therefore, RAS by angiotensin receptor blockers (ARBs) angiotensin‐converting enzyme inhibitors (ACEIs) may be effective reducing risk neuropathology. It has been shown that all components including peptides enzymes are present different areas. Brain plays a critical role regulation memory cognitive function, controlling central blood pressure. However, exaggerated implicated pathogenesis PD. Two well‐known pathways recognized including; classical pathway which mainly mediated AngII/AT1R detrimental effects. Conversely, non‐classical mostly ACE2/Ang1‐7/MASR AngII/AT2R beneficial effects against Exaggerated affects viability dopaminergic neurons. fundamental mechanism was not fully elucidated. Consequently, purpose this review to disclose mechanistic In addition, we try revise how ACEIs ARBs can developed for therapeutics

Language: Английский

Unveiling the interplay of AMPK/SIRT1/PGC-1α axis in brain health: Promising targets against aging and NDDs DOI
Pratik Shankar Rakshe, Bhaskar Jyoti Dutta, Shivani Chib

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102255 - 102255

Published: March 14, 2024

Language: Английский

Citations

29
BDNF/TrkB activators in Parkinson's disease: A new therapeutic strategy DOI Creative Commons

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(10)

Published: May 1, 2024

Parkinson's disease (PD) is a neurodegenerative disorder of the brain and manifested by motor non-motor symptoms because degenerative changes in dopaminergic neurons substantia nigra. PD neuropathology associated with mitochondrial dysfunction, oxidative damage apoptosis. Thus, modulation apoptosis growth factors could be novel boulevard management PD. Brain-derived neurotrophic factor (BDNF) its receptor tropomyosin kinase type B (TrkB) are chiefly involved neuropathology. BDNF promotes survival nigra enhances functional activity striatal neurons. Deficiency TrkB triggers degeneration accumulation α-Syn As well, BDNF/TrkB signalling reduced early phase Targeting specific activators may attenuate this review aimed to discuss potential role against In conclusion, decreased linked severity long-term complications. Activation

Language: Английский

Citations

20
Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night DOI Creative Commons
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb,

Ali K. Albuhadily

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Parkinson's disease (PD) is a progressive neurodegenerative brain due to degeneration of dopaminergic neurons (DNs) presented with motor and non-motor symptoms. PD symptoms are developed in response the disturbance diverse neurotransmitters including γ-aminobutyric acid (GABA). GABA has neuroprotective effect against neuropathology by protecting DNs substantia nigra pars compacta (SNpc). It been shown that GABAergic linked progression neurotransmission necessary pathway for normal sleep patterns, thus deregulation could be potential cause disorders PD.

Language: Английский

Citations

18
Long-term use of metformin and Alzheimer’s disease: beneficial or detrimental effects DOI
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, ‏Hebatallah M. Saad

et al.

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(3), P. 1107 - 1115

Published: Feb. 28, 2023

Language: Английский

Citations

42
Parkinson’s Disease Risk and Hyperhomocysteinemia: The Possible Link DOI Creative Commons
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Yaser Hosny Ali Elewa

et al.

Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(6), P. 2743 - 2759

Published: April 19, 2023

Abstract Parkinson’s disease (PD) is one of the most common degenerative brain disorders caused by loss dopaminergic neurons in substantia nigra (SN). Lewy bodies and -synuclein accumulation SN are hallmarks neuropathology PD. Due to lifestyle changes prolonged L-dopa administration, patients with PD frequently have vitamin deficiencies, especially folate, B6, B12. These augment circulating levels Homocysteine development hyperhomocysteinemia, which may contribute pathogenesis Therefore, this review aimed ascertain if hyperhomocysteinemia play a part oxidative inflammatory signaling pathways that development. Hyperhomocysteinemia implicated neurodegenerative disorders, including triggers progression different mechanisms, stress, mitochondrial dysfunction, apoptosis, endothelial dysfunction. Particularly, linked high systemic disorders. induces immune activation stress. In turn, activated response promotes hyperhomocysteinemia. hyperhomocysteinemia-induced immunoinflammatory abnormal aggravate PD, leading more severity. Also, like nuclear factor kappa B (NF-κB) nod-like receptor pyrin 3 (NLRP3) inflammasome other intricate conclusion, involved either directly via induction degeneration or indirectly pathways.

Language: Английский

Citations

39
Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator DOI Creative Commons

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: Oct. 25, 2023

Abstract Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles the lysosomes for degradation elimination. The mechanistic target of rapamycin (mTOR) main negative regulator autophagy. mTOR pathway involved in regulating neurogenesis, synaptic plasticity, neuronal development excitability. Exaggerated activity associated with temporal lobe epilepsy, genetic acquired experimental epilepsy. In particular, complex 1 (mTORC1) mainly epileptogenesis. investigation autophagy’s involvement epilepsy has recently been conducted, focusing on critical role rapamycin, autophagy inducer, reducing severity induced seizures animal model studies. induction could be innovative therapeutic strategy managing Despite protective against epileptogenesis its status epilepticus (SE) perplexing might beneficial or detrimental. Therefore, present review aims revise possible

Language: Английский

Citations

34
The potential therapeutic effect of statins in multiple sclerosis: beneficial or detrimental effects DOI
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, ‏Hebatallah M. Saad

et al.

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(4), P. 1671 - 1682

Published: May 9, 2023

Language: Английский

Citations

32
The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson’s Disease: The Way of New Inroads DOI

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(5), P. 2469 - 2480

Published: Oct. 28, 2023

Language: Английский

Citations

32
Role of Brain Liver X Receptor in Parkinson’s Disease: Hidden Treasure and Emerging Opportunities DOI Creative Commons

Saud A. Alnaaim,

Hayder M. Al‐kuraishy, Αθανάσιος Αλεξίου

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(1), P. 341 - 357

Published: Aug. 22, 2023

Abstract Parkinson’s disease (PD) is a neurodegenerative due to the degeneration of dopaminergic neurons (DNs) in substantia nigra (SN). The liver X receptor (LXR) involved different diseases. Therefore, objective present review was clarify possible role LXR PD neuropathology. LXRs are most common nuclear receptors transcription factors that regulate cholesterol metabolism and have pleiotropic effects, including anti-inflammatory effects reducing intracellular accumulation. highly expressed adult brain act as endogenous sensors for cholesterol. neuroprotective against development neuroinflammation diseases by inhibiting expression pro-inflammatory cytokines. play an essential mitigating neuropathology inflammatory signaling pathways, neuroinflammation, oxidative stress, mitochondrial dysfunction, enhancement BDNF signaling. In conclusion, LXRs, through regulating homeostasis, may be effectual PD. Also, inhibition node-like pyrin 3 (NLRP3) inflammasome factor kappa B (NF-κB) could effectively prevent Taken together, crucial associated DNs.

Language: Английский

Citations

28
Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel DOI
Hayder M. Al‐kuraishy, Majid S. Jabir, Ali I. Al‐Gareeb

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102119 - 102119

Published: Nov. 4, 2023

Language: Английский

Citations

27