Future Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Aug. 19, 2024
Abstract
Background
The
present
study
aims
to
enhance
the
wound
healing
potential
of
seed
oil
(SO)
Lagenaria
siceraria
(Egyptian
cultivar)
via
preparation
SO-loaded
binary
nanoethosomal
(SO-BNE)
gels.
SO-BNEs
were
prepared
using
2
3
factorial
design,
characterized
for
vesicle
size,
zeta
potential,
polydispersity
index,
linoleic
and
oleic
acid
EE%
ensuring
improved
skin
permeability.
L.
SO,
optimized
SO-BNE
gels
(0.5%
5%)
Mebo®
topically
applied
in
full-thickness
wounded
rat
model
twice
daily
10
days.
Results
In
gel
groups,
normal
appearance
architecture
structure
dermis
was
revealed.
addition,
levels
NRF2,
TGF-β1
FOXO1,
collagen
type
I,
SMA-α
MIP2
significantly
elevated.
proposed
be
suppression
oxidative
stress
stimulation
regeneration
biomarkers.
Furthermore,
SO
screening
through
GC/MS
unveiled
high
percentages
unsaturated
fatty
acids.
also
found
nontoxic
human
fibroblast
cells;
enhanced
viability
migration
rates
at
concentration
50
g/mL
by
99.76%
75.9%,
respectively.
Conclusion
These
findings
demonstrate
that
BNE
represent
a
promising
delivery
with
release
bioavailability.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1829 - 1829
Published: June 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(3), P. 327 - 327
Published: Feb. 26, 2024
Bacterial
infections
are
major
problems
in
wound
care
due
to
their
impact
on
the
retarded
process
of
healing,
leading
chronic
wounds.
Most
presently
utilized
dressing
products
exhibit
poor
antimicrobial
properties.
Wound
dressings
formulated
from
chitosan
have
been
reported
be
effective
for
treating
infected
wounds,
resulting
antibacterial
properties
chitosan.
The
chitosan-based
can
further
enhanced
by
incorporating
metallic
nanoparticles
into
them,
such
as
silver,
zinc,
titanium,
etc.
incorporation
silver
has
widely
explored
design
dressings.
promotes
accelerated
wound-healing
processes
activity.
healing
these
metal-based
is
via
regulation
re-epithelialization
and
inflammation
without
affecting
viability
normal
cells.
However,
there
few
reports
that
evaluate
infectious
animal
models
prove
efficacy.
vivo
toxicity
still
needs
addressed,
revealing
need
preclinical
clinical
trials.
fabrication
incorporated
with
not
fully
explored,
especially
wounds
requiring
immediate
treatment.
possible
interactions
between
scaffolds
result
synergistic
effects
understood
studied.
This
review
provides
a
comprehensive
report
outcomes
materials
loaded
managing
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 123 - 123
Published: Feb. 7, 2025
Recent
advancements
in
wound
dressing
materials
have
significantly
improved
acute
and
chronic
management
by
addressing
challenges
such
as
infection
control,
moisture
balance,
enhanced
healing.
Important
progress
has
been
made,
especially
with
hydrogels,
foams,
antimicrobial
for
creating
optimized
dressings.
Hydrogels
are
known
maintaining
optimal
levels,
while
foam
dressings
excellent
exudate
absorbents.
Meanwhile,
incorporates
various
agents
to
reduce
risks.
These
options
healing
time
focusing
on
customized
patient
needs.
Therefore,
this
review
highlights
the
newest
research
prototypes
applications,
emphasizing
their
particular
benefits
clinical
importance.
Innovations
stimuli-responsive
hydrogels
hybrid
bioengineered
composites
discussed
relation
properties,
including
responsiveness
pH,
temperature,
glucose,
or
enzymes
drug
delivery
precision.
Moreover,
ongoing
trials
included,
demonstrating
potential
of
emerging
solutions
be
soon
translated
from
laboratory
settings.
By
discussing
interdisciplinary
approaches
that
integrate
advanced
materials,
nanotechnology,
biological
insights,
work
provides
a
contemporary
framework
patient-centric,
efficient
care
strategies.
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(3), P. 1056 - 1076
Published: Jan. 30, 2024
Human
skin
is
the
largest
organ
and
outermost
surface
of
human
body,
due
to
continuous
exposure
various
challenges,
it
prone
develop
injuries,
customarily
known
as
wounds.
Although
tissue
engineering
strategies
bioactive
wound
matrices
have
been
employed
speed
up
healing,
scarring
remains
a
significant
challenge.
The
environment
harsh
presence
degradative
enzymes
elevated
pH
levels,
physiological
processes
involved
in
regeneration
operate
on
distinct
time
scales.
Therefore,
there
need
for
effective
drug
delivery
systems
(DDSs)
address
these
issues.
objective
this
review
provide
comprehensive
exposition
mechanisms
underlying
healing
process,
factors
materials
used
DDSs,
different
DDSs
care.
Furthermore,
investigation
will
delve
into
examination
emergent
technologies
potential
avenues
enhancing
efficacy
care
devices.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3274 - 3274
Published: March 14, 2024
Throughout
history,
natural
products
have
played
a
significant
role
in
wound
healing.
Fibroblasts,
acting
as
primary
cellular
mediators
skin
healing,
exhibit
behavioral
responses
to
compounds
that
can
enhance
the
healing
process.
Identifying
bioactive
and
understanding
their
impact
on
fibroblast
behavior
offers
crucial
translational
opportunities
realm
of
Modern
scientific
techniques
enabled
detailed
how
naturally
derived
modulate
by
influencing
behavior.
Specific
known
for
properties
been
identified.
Engineered
biomimetic
replicating
microenvironment
are
designed
facilitate
normal
Advanced
delivery
methods
operating
at
micro-
nano-scales
developed
effectively
deliver
these
novel
through
stratum
corneum.
This
review
provides
comprehensive
summary
efficacy
promoting
regeneration
repair.
Additionally,
it
explores
engineering,
where
researchers
draw
inspiration
from
nature
create
materials
devices
mimicking
physiological
cues
effective
The
concludes
describing
mechanisms
aimed
enhancing
bioavailability
compounds.
Innovative
future
strategies
involve
exploring
fibroblast-influencing
pathways,
responsive
biomaterials,
smart
dressings
with
real-time
monitoring,
applications
stem
cells.
However,
translating
findings
clinical
settings
faces
challenges
such
limited
validation
biomaterials
large
animal
models
logistical
obstacles
industrial
production.
integration
ancient
remedies
modern
approaches
holds
promise
achieving
scar-free
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 899 - 899
Published: Jan. 22, 2025
Previously
we
suggested
a
new
pharmaceutical
derived
from
coordination
complex
of
Co3+
with
polyacrylic
acid
(PAA)
exhibiting
hemostatic
and
microbicidal
activity,
namely
Hestatin.
Differences
in
the
physiological
activity
Hestatin
synthesized
PAA
10
kDa
(Hestatin
10)
200
200)
were
shown.
We
tested
acute
toxicity
its
effect
on
healing
rate
sterile
wounds
rats.
Free
PAA,
emulsion
wax,
wax
carrying
resveratrol,
dexpanthenol
for
comparison.
exhibited
no
when
administered
intragastrically
at
dosages
5
g
per
kg.
surpassed
all
drugs
wound
ability.
Histological
analysis
skin
sections
rats
area
defects
showed
an
increased
synthesis
reticular
fibers
compared
to
placebo.
In
early
stages
(inflammatory
phase),
stimulated
taxis
mast
cells
(MCs)
bottom
but
not
perimeter.
At
final
stage
(remodeling
promoted
MC
evacuation
defect
area.
This
is
opposite
well-known
wound-healing
agents
(dexpanthenol
resveratrol),
which
enhance
infiltration
into
remodeling
phase.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1517 - 1517
Published: May 17, 2023
Developing
an
efficient
and
cost-effective
wound-healing
substance
to
treat
wounds
regenerate
skin
is
desperately
needed
in
the
current
world.
Antioxidant
substances
are
gaining
interest
wound
healing,
green-synthesized
silver
nanoparticles
have
drawn
considerable
attention
biomedical
applications
due
their
efficient,
cost-effective,
non-toxic
nature.
The
present
study
evaluated
vivo
healing
antioxidant
activities
of
from
Azadirachta
indica
(AAgNPs)
Catharanthus
roseus
(CAgNPs)
leaf
extracts
BALB/c
mice.
We
found
rapid
higher
collagen
deposition,
increased
DNA
protein
content
AAgNPs-
CAgNPs
(1%
w/w)-treated
than
control
vehicle
wounds.
Skin
enzyme
(SOD,
catalase,
GPx,
GR)
were
significantly
(p
<
0.05)
after
11
days
AAgNPs
treatment.
Furthermore,
topical
application
tends
suppress
lipid
peroxidation
wounded
samples.
Histopathological
images
evidenced
decreased
scar
width,
epithelium
restoration,
fine
fewer
inflammatory
cells
applied
In
vitro,
free
radical
scavenging
activity
was
demonstrated
by
DPPH
ABTS
assays.
Our
findings
suggest
that
prepared
C.
A.
status
improved
process
Therefore,
these
could
be
potential
natural
antioxidants
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Oct. 2, 2024
Wound
management
spans
various
techniques
and
materials
tailored
to
address
acute
chronic
non-healing
wounds,
with
the
primary
objective
of
achieving
successful
wound
closure.
Chronic
wounds
pose
additional
challenges,
often
necessitating
dressings
prepare
bed
for
subsequent
surgical
procedures
like
skin
grafting.
Ideal
dressing
should
not
only
expedite
healing
but
also
mitigate
protein,
electrolyte,
fluid
loss
while
minimizing
pain
infection
risk.
Nanotechnology
has
emerged
as
a
transformative
tool
in
care,
revolutionizing
landscape
biomedical
dressings.
Its
application
offers
remarkable
efficacy
accelerating
combating
bacterial
infections,
representing
significant
advancement
care
practices.
Integration
nanotechnology
into
resulted
enhanced
properties,
including
improved
mechanical
strength
controlled
drug
release,
facilitating
therapeutic
interventions.
This
review
article
comprehensively
explores
recent
breakthroughs
therapies,
focus
on
innovative
medical
such
nano-enzymes.
Additionally,
utilization
smart
materials,
hydrogels
electroactive
polymers,
dynamic
functionalities
promote
tissue
regeneration.
Emerging
concepts
bio-fabrication,
microfluidic
systems,
bio-responsive
scaffolds,
personalized
therapeutics
show
promise
expediting
scarring.
Through
an
in-depth
exploration
these
advancements,
this
aims
catalyze
paradigm
shift
strategies,
promoting
patient-centric
approach
