The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 151 - 151

Published: Jan. 20, 2025

Quercetin, a flavonoid found in vegetables and fruits, has been extensively studied for its health benefits disease management. Its role the prevention of various pathogenesis well-documented, primarily through ability to inhibit oxidative stress, inflammation, enhance endogenous antioxidant defense mechanisms. Electronic databases such as Google Scholar, Scopus, PubMed, Medline, Web Science were searched information regarding quercetin pathogeneses. The included literature comprised experimental studies, randomized controlled trials, epidemiological studies related quercetin, while editorials, case analyses, theses, letters excluded. It reported have wide range including hepatoprotective, antidiabetic, anti-obesity, neuroprotective, cardioprotective, wound healing, antimicrobial, immunomodulatory effects, achieved modulation biological activities. Additionally, numerous vitro vivo shown that quercetin’s efficacies cancer management involve inhibiting cell signaling pathways, cycle, angiogenesis, activating pathways tumor suppressor genes, inducing apoptosis. This review aims provide comprehensive understanding this outlines sources nanoformulations, applications management, along with key findings from important clinical trial studies. Limited data safety mechanism action are available. is conduct more trials gain deeper disease-preventive potential, mechanisms action, safety, optimal therapeutic dosages. Furthermore, research based on nanoformulations should be performed minimize/overcome hindrance associated bioavailability, rapid degradation, toxicity.

Language: Английский

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Luteolin inhibits inflammation and M1 macrophage polarization in the treatment of Pseudomonas aeruginosa-induced acute pneumonia through suppressing EGFR/PI3K/AKT/NF-κB and EGFR/ERK/AP-1 signaling pathways

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156663 - 156663

Published: March 1, 2025

Language: Английский

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Quercetin Protects Blood–Brain Barrier Integrity via the PI3K/Akt/Erk Signaling Pathway in a Mouse Model of Meningitis Induced by Glaesserella parasuis

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 696 - 696

Published: June 14, 2024

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Systematic Investigation of Metabolism and Potential Pharmacological Mechanism of Tanreqing Injection to Human Lower Respiratory Tract Infection Based on UPLC–Q–TOF–MS^E and Network Pharmacology

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 12, 2025

ABSTRACT Tanreqing injection (TRQI), a well‐known traditional Chinese medicine, has marked curative effect on lower respiratory tract infections. A strategy using ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry (UPLC–Q–TOF–MS E ) for rapid identification of metabolites from TRQI was proposed by UNIFI informatics platform combined multiple data processing techniques. Target prediction then performed based the original compounds in vivo, and network between active common targets established Cytoscape v3.9.0. As result, 64 were characterized TRQI, 54 76 detected human plasma urine, two which (M28 M45) novel metabolites. metabolic pathway lonicerin identified. The compound‐target‐pathway identified 22 target genes 20 signaling pathways that linked to these mechanisms. key mechanism is related JAK‐STAT PI3K‐Akt pathway. bioactive ingredients mechanisms action TQRI against infections vivo explored through pharmacology molecular docking. This first study humans been clarified.

Language: Английский

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Kaempferol Mitigates Pseudomonas aeruginosa-Induced Acute Lung Inflammation Through Suppressing GSK3β/JNK/c-Jun Signaling Pathway and NF-κB Activation

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 322 - 322

Published: Feb. 25, 2025

Background: Pseudomonas aeruginosa, one of the common bacterial pathogens causing nosocomial pneumonia, is characterized as highly pathogenic and multidrug-resistant. Kaempferol (KP), a natural flavonoid, has been shown to exhibit effectiveness in treating infection-induced lung injury. Methods: We applied network pharmacology explore underlying mechanisms KP P. aeruginosa pneumonia further validated them through mouse model acute infection an vitro macrophage model. Results: The vivo studies demonstrated that treatment with suppressed production proinflammatory cytokines, including TNF, IL-1β, IL-6, MIP-2, attenuated neutrophil infiltration lesions lungs, leading increased survival rate mice. Further revealed enhanced phosphorylation GSK3β at Ser9 diminished JNK, c-Jun, NF-κB p65 lungs comparison mice without drug treatment. Consistently, showed pretreatment reduced activation GSK3β, decreased levels cytokines macrophages during infection. Conclusions: by inhibiting GSK3β/JNK/c-Jun signaling pathways activation, which effectively mitigated aeruginosa-induced inflammation injury, elevated rates

Language: Английский

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Integrated metabolomics and network pharmacology to investigate the effects of Yi-Qi-Xuan-Fei-Hua-Tan decoction for treating acute respiratory distress syndrome

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(4), P. 1969 - 1981

Published: Feb. 28, 2025

Background: Acute respiratory distress syndrome (ARDS) is a common severe lung disease with high morbidity and mortality. Yi-Qi-Xuan-Fei-Hua-Tan decoction (YQXFHT) based on the classical formula of Ma-Xing-Shi-Gan flavor addition. Methods: First, global view potential compound-target-pathway network pharmacology was constructed to provide preliminary understanding active compounds. Subsequently, in vivo efficacy YQXFHT verified mouse model. Meanwhile, metabolic mechanism treatment ARDS explored using corresponding metabolomic profiles. Results: Five components 10 core targets for were obtained through pharmacological studies. Potential activities include isorhamnetin, jaranol, medicarpin, quercetin, mandneol, STAT3, PIK3CA, PIK3CD, NRAS, AKT1, PTPN11, JAK1, EGFR, IL-6, CTNNB1. Besides, pathways analyzed by Kyoto Gene Genome Encyclopedia enrichment analysis, mainly including estrogen, IL-17, TNF, FoxO, PI3k-Akt, HIF-1 signaling pathways, etc. It shown that docking model between target its stable molecular docking. Finally, metabolomics, it concluded can be activated unsaturated fatty acid synthesis, linoleic metabolism, lysine degradation, arginine proline drug metabolism-cytochrome P450 exert effects ARDS. Conclusion: This study highlighted reliability validity metabolomics pharmacology-based approach identified validated complexes natural elucidate therapeutic mechanisms

Language: Английский

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Kurarinone Attenuates LPS‐Induced Pneumonia by Inhibiting MAPK and NF‐κB Signaling Pathways

Apmis, Journal Year: 2025, Volume and Issue: 133(3)

Published: March 1, 2025

Kurarinone is a prenylated flavanone isolated from Sophora flavescens Aiton. This investigation aimed to elucidate whether kurarinone could ameliorate lipopolysaccharide (LPS)-induced pneumonia and explore the underlying mechanism. C57BL/6 mice were treated with LPS (50 μg/20 μL) establish models. (100 mg/kg) or dexamethasone (DEX, 5 was administered for 7 days before inhalation. BEAS-2B cells incubated at 1, 2, μM 2 h stimulation 24 h. We found that ameliorated lung injury inflammatory cell infiltration in mouse (p < 0.001). decreased MPO activity (47.6%, p 0.001) alleviated response by reducing levels of IL-1β (34.9%, 0.001), TNF-α (55.1%, IL-6 (36.2%, lung. reduced IL-1β, TNF-α, IL-6, iNOS, COX2 LPS-treated concentration-dependent manner 0.05). Mechanistically, restrained LPS-induced activation MAPK NF-κB pathways vivo vitro Overall, alleviates inflammation via pathways, suggesting might be potential therapeutic agent pneumonia. study provides new research ideas discovery natural flavonoids can treat

Language: Английский

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Anti-Inflammatory Potential of Quercetin: From Chemistry and Mechanistic Insight to Nanoformulations

Current Research in Pharmacology and Drug Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100217 - 100217

Published: March 1, 2025

Language: Английский

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Flavor Profile of 4-Isothiocyanato-1-butene in Microwave Rapeseed Oil and Its Anti-Inflammatory Properties In Vitro

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

4-Isothiocyanato-1-butene (4-BITC) is a crucial plant isothiocyanate; however, its flavor profile in microwave rapeseed oil and anti-inflammatory properties have not been elucidated detail. Therefore, this study, the distribution of 4-BITC 45 oils was quantitated using selected ion monitoring, with concentrations ranging from 0.29 to 8.63 mg/kg. The odor activity values ranged 4 123. In lipopolysaccharide (LPS)-induced RAW264.7 cell model, exerted dose-dependent effects, which resulted remarkable differences 20 lipid mediators between LPS groups. Kyoto Encyclopedia Genes Genomes analysis revealed that downregulated proinflammatory oxylipins by modulating CYP, LOX, COX pathways, thereby preventing arachidonic acid metabolism disorders. Molecular docking further confirmed inhibited PI3K/Akt/NF-κB signaling cascade alleviate inflammation.

Language: Английский

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Fatty Acids Derived from Royal Jelly Exert Anti-Inflammatory and Antibacterial Activities in the Treatment of Pseudomonas aeruginosa-Induced Acute Pneumonia

Journal of Medicinal Food, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

, an opportunistic pathogen, commonly causes hospital-acquired pneumonia. Royal jelly fatty acids (RJFAs), a mixture of various extracted from royal jelly, exhibit antibacterial and anti-inflammatory properties in treating many infectious diseases. Nevertheless, the therapeutic mechanisms RJFAs treatment acute

Language: Английский

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