Modeling impairment of ionic regulation with extended Adaptive Exponential integrate-and-fire models DOI Creative Commons
Damien Depannemaecker, Federico Tesler, Mathieu Desroches

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Abstract To model the dynamics of neuron membrane excitability many models can be considered, from most biophysically detailed to highest level phenomenological description. Recent works at single have shown importance taking into account evolution slow variables such as ionic concentration. A reduction a integrate-and-fire family is interesting then go large network models. In this paper, we introduce way consider impairment regulation by adding third, slow, variable adaptive Exponential (AdEx). We implement and simulate including model. find that was able generate normal epileptic discharges. This should useful for design simulations pathological states.

Language: Английский

Biophysically inspired mean-field model of neuronal populations driven by ion exchange mechanisms DOI Open Access
Giovanni Rabuffo, Abhirup Bandyopadhyay, Carmela Calabrese

et al.

Published: Feb. 3, 2025

Whole-brain simulations are a valuable tool for gaining insight into the multiscale processes that regulate brain activity. Due to complexity of brain, it is impractical include all microscopic details in simulation. Hence, researchers often simulate as network coupled neural masses, each described by mean-field model. These models capture essential features neuronal populations while approximating most biophysical details. However, may be important certain parameters significantly impact function. The concentration ions extracellular space one key factor consider, its fluctuations can associated with healthy and pathological states. In this paper, we develop new model population Hodgkin–Huxley-type neurons, retaining perspective on ion-exchange mechanisms driving This allows us maintain interpretability bridging gap between micro- macro-scale mechanisms. Our able reproduce wide range activity patterns, also observed large simulations. Specifically, slow-changing ion concentrations modulate fast neuroelectric activity, feature our validated through vitro experiments. By studying how changes ionic conditions affect whole-brain dynamics, serves foundation measure biomarkers provide potential therapeutic targets cases dysfunctions like epilepsy.

Language: Английский

Citations

0
Dynamical regulation of epileptiform discharges caused by abnormal astrocyte function with optogenetic stimulation DOI
Jinyi Zhao, Ying Yu,

Qingyun Wang

et al.

Chaos Solitons & Fractals, Journal Year: 2022, Volume and Issue: 164, P. 112720 - 112720

Published: Oct. 6, 2022

Language: Английский

Citations

13
Multi-scale modelling of the epileptic brain: advantages of computational therapy exploration DOI

Rongqi Hong,

Tingting Zheng,

Vincenzo Marra

et al.

Journal of Neural Engineering, Journal Year: 2024, Volume and Issue: 21(2), P. 021002 - 021002

Published: April 1, 2024

Abstract Objective : Epilepsy is a complex disease spanning across multiple scales, from ion channels in neurons to neuronal circuits the entire brain. Over past decades, computational models have been used describe pathophysiological activity of epileptic brain different aspects. Traditionally, each model can aid optimizing therapeutic interventions, therefore, providing particular view design strategies for treating epilepsy. As result, most studies are concerned with generating specific that help us understand certain machinery pathological state. Those vary complexity and biological accuracy, system-level often lacking details. Approach Here, we review various types epilepsy discuss their potential approaches scenarios, including drug discovery, surgical strategies, stimulation, seizure prediction. We propose need consider an integrated approach unified modelling framework scales Our proposal based on recent increase power, which has opened up possibility unifying those into simulations unprecedented level detail. Main results A multi-scale bridge gap between biologically detailed models, address molecular cellular questions, brain-wide abstract account neurological behavioural observations. Significance With these efforts, move toward next generation capable connecting features, such as channel properties, standard clinical measures severity.

Language: Английский

Citations

2
The Na+/K+-ATPase generically enables deterministic bursting in class I neurons by shearing the spike-onset bifurcation structure DOI Creative Commons

Mahraz Behbood,

Louisiane Lemaire,

Jan-Hendrik Schleimer

et al.

PLoS Computational Biology, Journal Year: 2024, Volume and Issue: 20(8), P. e1011751 - e1011751

Published: Aug. 12, 2024

Slow brain rhythms, for example during slow-wave sleep or pathological conditions like seizures and spreading depolarization, can be accompanied by oscillations in extracellular potassium concentration. Such slow rhythms typically have a lower frequency than tonic action-potential firing. They are assumed to arise from network-level mechanisms, involving synaptic interactions delays, intrinsically bursting neurons. Neuronal burst generation is commonly attributed ion channels with kinetics. Here, we explore an alternative mechanism generically available all neurons class I excitability. It based on the interplay of fast-spiking voltage dynamics one-dimensional concentration, mediated activity Na + /K -ATPase. We use bifurcation analysis complete system as well slow-fast method reveal that this coupling suffices generate hysteresis loop organized around bistable region emerges saddle-node bifurcation–a common feature excitable Depending strength -ATPase, bursts generated pump-induced shearing structure, spiking tonic, cells silenced via depolarization block. suggest transitions between these result disturbances regulation, such glial malfunction hypoxia affecting -ATPase activity. The identified minimal mechanistic model outlining sodium-potassium pump’s generic contribution can, therefore, contribute better understanding pathologies epilepsy syndromes and, potentially, inform therapeutic strategies.

Language: Английский

Citations

2
The role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence DOI
Duo Li, Sihui Li, Min Pan

et al.

Cognitive Neurodynamics, Journal Year: 2023, Volume and Issue: 18(2), P. 485 - 502

Published: Sept. 21, 2023

Language: Английский

Citations

6
Does Deep Learning Have Epileptic Seizures? On the Modeling of the Brain DOI
Damien Depannemaecker, Léo Pio-Lopez, Christophe Gauld

et al.

Cognitive Computation, Journal Year: 2023, Volume and Issue: 16(5), P. 2382 - 2388

Published: Feb. 23, 2023

Language: Английский

Citations

4
How neuronal morphology impacts the synchronisation state of neuronal networks DOI Creative Commons
Robert P. Gowers, Susanne Schreiber

PLoS Computational Biology, Journal Year: 2024, Volume and Issue: 20(3), P. e1011874 - e1011874

Published: March 4, 2024

The biophysical properties of neurons not only affect how information is processed within cells, they can also impact the dynamical states network. Specifically, cellular dynamics action-potential generation have shown relevance for setting (de)synchronisation state tonically spiking typically fall into one three qualitatively distinct types that arise from mathematical bifurcations voltage at onset spiking. Accordingly, changes in ion channel composition or even external factors, like temperature, been demonstrated to switch network behaviour via spike bifurcation and hence its associated type. A thus far less addressed modulator neuronal morphology. Based on simplified anatomically realistic neuron models, we show here extent dendritic arborisation has an influence type therefore larger trees prime in-phase-synchronised splayed-out activity weakly coupled networks, contrast cells with otherwise identical yet smaller dendrites. Our insights hold generic multicompartmental classes models (from ball-and-stick-type reconstructed models) establish a connection between morphology susceptibility neural tissue synchronisation health disease.

Language: Английский

Citations

1
Transition and Propagation of Epilepsy in an Improved Epileptor Model Coupled with Astrocyte DOI
Kesong An, Lin Du, Honghui Zhang

et al.

International Journal of Bifurcation and Chaos, Journal Year: 2024, Volume and Issue: 34(03)

Published: March 11, 2024

In this paper, a tripartite synapse network is constructed to examine external and internal triggering factors of epilepsy transition propagation in neurons with the Epileptor-2 model. We first explore stimuli environment that induce epileptic activities behaviors among Ictal Discharges (IDs) Interictal (IIDs) states. The higher strength abruptness stimuli, more severe occurrence within reasonable range parameters. Then for factors, results network, which improved by combining model astrocyte means ion exchange new connections, show astrocytes can transmit normal physiological activity information filter out abnormal discharge neurons. One causes seizures release glial neurotransmitters astrocytes. excessive glutamate state transit from nonepileptic IIDs, IDs tonic, while adenosine triphosphate alleviate epilepsy. Meanwhile, dysfunction an astrocyte-free also lead seizures, ability becomes weaker than network. Our research expected provide some theoretical basis therapeutic approach curing intracellular extracellular contexts.

Language: Английский

Citations

1
GABA-induced seizure-like events caused by multi-ionic interactive dynamics DOI Creative Commons
Zichao Liu, Erik De Schutter, Yinyun Li

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(10), P. ENEURO.0308 - 24.2024

Published: Oct. 1, 2024

Experimental evidence showed that an increase in intracellular chloride concentration ([Cl−]i) caused by gamma-aminobutyric acid (GABA) input can promote epileptic firing activity, but the actual mechanisms remain elusive. Here this theoretical work, we show influx of and concomitant bicarbonate ion stretchy="false">(HCO3−l−]i . found increases, system exhibits saddle–node bifurcation, above which spectrum intensive firing, periodic bursting interrupted depolarization block (DB) state, eventually stable DB through Hopf bifurcation. demonstrate only stimuli together with overflow="scroll">HCO3− switch GABA's effect excitation leads series seizure-like events (SLEs). Exposure low stretchy="false">[K+]bath drive neurons high concentrations downward lower levels , during it could also trigger SLEs depending on exchange rate bath. Our analysis simulation results how competition between stimuli-induced accumulation mathvariant="normal">bath application-induced decrease regulates helps understand fundamental ionic dynamics SLE.

Language: Английский

Citations

1
Examining the low-voltage fast seizure-onset and its response to optogenetic stimulation in a biophysical network model of the hippocampus DOI
Liyuan Zhang, Zhiyuan Ma, Ying Yu

et al.

Cognitive Neurodynamics, Journal Year: 2023, Volume and Issue: 18(1), P. 265 - 282

Published: Feb. 10, 2023

Language: Английский

Citations

3