IFMBE proceedings, Journal Year: 2024, Volume and Issue: unknown, P. 726 - 745
Published: Jan. 1, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: April 14, 2023
Three dimensional (3D) bioprinting is a powerful tool, that was recently applied to tissue engineering. This technique allows the precise deposition of cells encapsulated in supportive bioinks fabricate complex scaffolds, which are used repair targeted tissues. Here, we review recent developments application 3D dental These tissues, including teeth, periodontal ligament, alveolar bones, and pulp, present cell types mechanical properties with great heterogeneity, challenging reproduce vitro. After highlighting different methods regenerative dentistry, reviewed variety bioink formulations their effects on cells, have been established support development these We discussed advances achieved fabrication each provide an overview current state methods. conclude remaining challenges future needs.
Language: Английский
Citations
25
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(2)
Published: Feb. 13, 2024
Abstract The use of photobiomodulation therapy (PBMT) may be used for treating trauma to the maxillofacial region. effects PBMT on injuries were discussed in this review article. electronic databases Pubmed, Scopus, and Web Science thoroughly searched. This included vitro, vivo, clinical studies describing how can tissue engineering regenerative medicine. Some suggest that offer a promising traumatic because it stimulate differentiation proliferation various cells, including dental pulp cells mesenchymal stem enhancing bone regeneration osseointegration. reduces pain swelling after oral surgery tooth extraction human animal models injuries. Patients with temporomandibular disorders also benefit from terms reduced inflammation symptoms. still has some limitations, such as need standardizing parameters. must evaluated further randomized controlled trials As result, offers safe noninvasive treatment option patients suffering requires research establish its efficacy practice determine optimal
Language: Английский
Citations
10
JCI Insight, Journal Year: 2025, Volume and Issue: 10(1)
Published: Jan. 8, 2025
The oral mucosa undergoes daily insults, and stem cells in the epithelial basal cell layer regenerate gingiva tissue to maintain health. Iroquois Homeobox 1 (IRX1) protein is expressed niches human/mouse epithelium mesenchyme under homeostasis. We found that Irx1+/- heterozygous (Het) mice have delayed wound closure, morphological changes of regenerated epithelium, defective keratinocyte proliferation differentiation during healing. RNA-Seq analyses between WT at 3 days postinjury (dpi) impaired migration decreased keratinocyte-related genes upon injury. IRX1-expressing are gingival layer, a niche for maintenance. also underlying stroma. IRX1 activates SOX9 transient amplifying increase proliferation, EGF signaling activated induce migration. Krt14CreERT lineage tracing experiments reveal defects stratification HET mouse epithelium. primed base facilitating rapid scarless healing through activating pathway.
Language: Английский
Citations
1
Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102766 - 102766
Published: Jan. 1, 2025
Language: Английский
Citations
1
Journal of Cancer Research and Clinical Oncology, Journal Year: 2023, Volume and Issue: 149(10), P. 7945 - 7968
Published: March 11, 2023
Language: Английский
Citations
18
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1986 - 1986
Published: Feb. 6, 2024
Mesenchymal stem/stromal cells (MSCs) are multipotent located in different areas of the human body. The oral cavity is considered a potential source MSCs because they have been identified several dental tissues (D-MSCs). Clinical trials which from these sources were used shown that effective and safe as treatments for tissue regeneration. Importantly, immunoregulatory capacity has observed all populations; however, this function may vary among types MSCs. Since property clinical interest cell therapy protocols, it relevant to analyze differences capacity, well mechanisms by each type MSC. Interestingly, D-MSCs most suitable regenerating mineralized region. Furthermore, supported due their adequate proliferation, migration, differentiation. There also evidence application protocols against autoimmune diseases other inflammatory conditions immunosuppressive capacity. Therefore, review, at preclinical level combination with found described, addition description applied.
Language: Английский
Citations
7
Maxillofacial Plastic and Reconstructive Surgery, Journal Year: 2024, Volume and Issue: 46(1)
Published: April 28, 2024
An essential aspect of rhinoplasty is the enhancement nasal dorsal contour by performing augmentation (DA) rhinoplasty. A wide range techniques are available for DA as demand aesthetic refinement grows. This review aims to provide a comprehensive overview current used in
Language: Английский
Citations
7
Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1065 - 1065
Published: June 19, 2024
Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells targeted 3D scaffolds have been investigated in the search for workable solutions. The use of cell-assisted regeneration is a crucial component engineering techniques designed overcome drawbacks grafts. This study provides detailed review scaffold applications with dentistry. focuses on while covering broad range studies explaining dentistry through presentation conducted this field. role different regenerative medicine covered great detail reviewed literature. These addressed wide subjects, including effects platelet concentrates during surgery specific combinations, such as human pulp animal model regeneration, promote models. Noting developments, research works consider methods improve vascularization explore 3D-printed scaffolds, secretome applications, mesenchymal cells, biomaterials regeneration. thorough assessment outlines possible developments these cycles insights suggestions additional study. Furthermore, alternative creative regenerating include biophysical stimuli, mechanical stimulation, magnetic field therapy, laser nutritional supplements diet, gene biomimetic materials. innovative offer promising avenues future development
Language: Английский
Citations
6
Biomimetics, Journal Year: 2024, Volume and Issue: 9(8), P. 480 - 480
Published: Aug. 9, 2024
The periodontal tissue is made up of supporting tissues and among its functions, it promotes viscoelastic properties, proprioceptive sensors, dental anchorage. Its progressive destruction by disease leads to the loss bone ligaments. For this reason, biomaterials are constantly being developed restore function. Various techniques used promote regenerative dentistry, including 3D bioprinting with bioink formulations. This paper aims review different types formulations in regeneration. Different have been formulated, addition materials into bioinks has conducted, intention improving process creating a that supports cell viability, proliferation, differentiation, stability for
Language: Английский
Citations
6
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 165, P. 112496 - 112496
Published: May 3, 2024
Language: Английский
Citations
5