How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges DOI Creative Commons
Jan Sobieraj, K. Strzelecka, Marcin Sobczak

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4607 - 4649

Published: May 1, 2024

Abstract: Cannabinoids are compounds found in and derived from the Cannabis plants that have become increasingly recognised as significant modulating factors of physiological mechanisms inflammatory reactions organism, thus inevitably affecting maintenance homeostasis. Medical popularity has surged since its legal regulation growing around world. Numerous promising discoveries bring more data on cannabinoids' pharmacological characteristics therapeutic applications. Given current surge interest medical use cannabinoids, there is an urgent need for effective method their administration. Surpassing low bioavailability, water solubility, instability became important milestone advancement cannabinoids pharmaceutical The numerous uses clinical practice remain restricted by limited administration alternatives, but hope when biodegradable polymers taken into account. primary objective this review to highlight wide range indications which may be used, well polymeric carriers enhance effectiveness. described a applications including pain management, neurological sleep disorders, anxiety, cancer treatment. these was further examined area dermatology cosmetology. Finally, with polymer-based drug delivery systems (DDSs), it demonstrated can delivered specifically intended site while also improving drug's physicochemical properties, emphasizing utility. Nevertheless, additional trials novel formulations required, full spectrum therapeutical potential yet unravelled. Keywords: systems, cannabidiol, tetrahydrocannabinol, polymers, nanomedicine

Language: Английский

Compressible Hydrogels with Stabilized Chirality from Thermoresponsive Helical Dendronized Poly(phenylacetylene)s DOI

Lefei Shen,

Yuexin Cao,

Lei Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)

Published: May 21, 2024

Fabrication of chiral hydrogels from thermoresponsive helical dendronized phenylacetylene copolymers (PPAs) carrying three-fold dendritic oligoethylene glycols (OEGs) is reported. Three different temperatures, i.e. below or above cloud point temperatures (T

Language: Английский

Citations

5
Antimicrobial, Probiotic, and Immunomodulatory Potential of Cannabis sativa Extract and Delivery Systems DOI Creative Commons
Anna Stasiłowicz-Krzemień, Daria Szymanowska, Piotr Szulc

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(4), P. 369 - 369

Published: April 17, 2024

The compounds present in hemp show multidirectional biological activity. It is related to the presence of secondary metabolites, mainly cannabinoids, terpenes, and flavonoids, synergy their aim this study was assess activity Henola Cannabis sativae extract its combinations with selected carriers (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer, magnesium aluminometasilicate, hydroxypropyl-β-cyclodextrin) terms antimicrobial, probiotic, immunobiological effects. As a result conducted research, antimicrobial confirmed relation following microorganisms: Clostridium difficile, Listeria monocytogenes, Enterococcus faecalis, Staphylococcus aureus, pyrogenes, Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium, Pseudomonas aereuginosa, Candida albicans (microorganism count reduced from ~102 CFU mL−1 <10 most cases). Additionally, for system hydroxypropyl-β-cyclodextrin, significant probiotic potential against bacterial strains established Lactobacillus acidophilus, casei, plantarum, brevis, rhamnosus, reuteri, Pediococcus pentosaceus, Lactococcus lactis, fermentum, Streptococcus thermophilus increased 104–107). In immunomodulatory properties, it determined that tested systems caused changes IL-6, IL-8, TNF-α levels.

Language: Английский

Citations

4
Effects of Polyhydroxybutyrate-co-hydroxyvalerate Microparticle Loading on Rheology, Microstructure, and Processability of Hydrogel-Based Inks for Bioprinted and Moulded Scaffolds DOI Creative Commons

Mercedes Pérez-Recalde,

Emilio Pérez‐Pacheco, Beatriz Aráoz

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 200 - 200

Published: March 14, 2025

Resorbable microparticles can be added to hydrogel-based biocompatible scaffolds improve their mechanical characteristics and allow localised drug delivery, which will aid in tissue repair regeneration. It is well-known that bioprinting important for producing personalised patients by loading them with own cells printing specified shapes dimensions. The question how the addition of such particles affects rheological responsiveness hydrogels (which critical during process) as well parameters like elastic modulus. This study tries answer this using a specific system: an alginate-gelatine hydrogel containing polyhydroxybutyrate-co-hydroxyvalerate (PHBV) microparticles. Scaffolds were made moulding incorporating PHBV microspheres (7–12 μm diameter) into alginate–gelatine inks (4.5 9.0% w/v). (MP) predominantly located within polymeric matrix at concentrations up 10 mg MP/mL ink. Higher particle disrupted spatial distribution. Inks pre-crosslinked 15 mM calcium containingMPat ranging from 0 mg/mL demonstrated appropriate bioprinting, solid-like behaviour (G′ = 1060–1300 Pa, G″ 720–930 Pa), yield stresses 320–400 pseudoplastic (static viscosities 4000–5600 Pa·s ~100 shear rates). Furthermore, these high quality, assessed through scaffold dimensions, filament widths, printability (Pr > 0.94). modulus elasticity compression (E) varied according content MP manufacturing technique, values resembling those soft tissues (200–600 kPa) exhibiting maximum reinforcement effect 3 ink (bioprinted E 273 ± 28 kPa; moulded 541 66 kPa). Over course six days, sample’s mass shape remained stable degradation simulated body fluid (SBF). Thus, loaded shows promise targeted delivery bioengineering applications.

Language: Английский

Citations

0
The Incorporation of CBD into Biodegradable DL-Lactide/Glycolide Copolymers Creates a Persistent Antibacterial Environment: An In Vitro Study on Streptococcus mutans and Staphylococcus aureus DOI Creative Commons
Ronit Vogt Sionov,

Ahmad Siag,

Emma Theresa Mersini

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 463 - 463

Published: April 2, 2025

Background: Cannabidiol (CBD) is a natural compound from the Cannabis sativa L. plant, which has anti-inflammatory, anti-nociceptive, neuroprotective, and antibacterial activities. Objective: The aim of this study was to develop sustained-release device CBD that can provide an effect against Gram-positive bacteria Streptococcus mutans Staphylococcus aureus for extended periods time. Methods: incorporated into biodegradable PURASORB 5010 or 7510 DL-lactide/glycolide polymers using either dimethylsulfoxide (DMSO) acetone as solvent, dried polymer scaffolds were exposed daily fresh culture bacteria. bacterial growth determined by optical density, metabolic activity biofilms MTT assay. Biofilm formation on visualized HR-SEM. Its anti-inflammatory measuring IL-6 release LPS-stimulated RAW 264.7 macrophages ELISA. Cell cytotoxicity normal Vero epithelial cells gas chromatography–mass spectrometry (GC-MS). Results: 5010/CBD had S. UA159, ATCC25923, clinical isolate multidrug-resistant (MDRSA CI-M) strain tested period up 17 days. 7510/CBD also activity, but overall, it less effective than over addition PEG400 copolymers significantly increased not 5010/CBD. sufficient reduce LPS-induced secretion macrophages, importantly, cytotoxic cells. found be between 1.12 9.43 µg/mL, far below dose 25 µg/mL. Conclusions: incorporation used prepare devices medical purposes where combined activities are desirable.

Language: Английский

Citations

0
Synthesis of an experimental gel containing cannabidiol oil and evaluation of effects on bleached bovine enamel DOI

Issae Sousa Sano,

Aila Silva de Almeida,

Gabriela Monteiro Barbosa

et al.

Odontology, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Language: Английский

Citations

0
Exploring the Potential of Nonpsychoactive Cannabinoids in the Development of Materials for Biomedical and Sports Applications DOI

Dulexy Solano-Orrala,

Dennis A. Silva-Cullishpuma,

Eliana Díaz-Cruces

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

This Perspective explores the potential of nonpsychoactive cannabinoids (NPCs) such as CBD, CBG, CBC, and CBN in developing innovative biomaterials for biomedical sports applications. It examines their physicochemical properties, anti-inflammatory, analgesic, neuroprotective effects, integration into various hydrogels, sponges, films, scaffolds. also discusses current challenges standardizing formulations, understanding long-term intrinsical regulatory landscapes. Further, it promising applications NPC-loaded materials bone regeneration, wound management, drug delivery systems, emphasizing improved biocompatibility, mechanical therapeutic efficacy demonstrated

Language: Английский

Citations

1
Cannabidiol (CBD) as an emerging nutraceutical ingredient from industrial hemp: regulation, production, extraction, nutraceutical properties, and functionality DOI
Anto Pradeep Raja Charles, Bingcan Chen, Jiajia Rao

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 9, 2024

Cannabidiol (CBD) in industrial hemp is a promising functional food ingredient with multifarious health benefits, including anticancer activity, antioxidant anti-inflammatory properties, and anxiolytic effects. In recent years, the application of CBD industry has been emerging several fortified products are available across globe. Currently, scientific information associated segregated, there lack connectivity between their explorations. Therefore, this review, findings that crucial for extending its applications comprehensively discussed. It begins by exploring global regulatory landscape CBD. Followingly, factors affect production field, isolation techniques from flowers, properties detailed. Importantly, review examines reported delivery systems enhancing physicochemical bioavailability CBD, thus broadening potential industry. Overall, would connect patches field to be resourceful scientists, agencies, farmers.

Language: Английский

Citations

1
Compressible Hydrogels with Stabilized Chirality from Thermoresponsive Helical Dendronized Poly(phenylacetylene)s DOI

Lefei Shen,

Yuexin Cao,

Lei Wang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(34)

Published: May 21, 2024

Abstract Fabrication of chiral hydrogels from thermoresponsive helical dendronized phenylacetylene copolymers (PPAs) carrying three‐fold dendritic oligoethylene glycols (OEGs) is reported. Three different temperatures, i.e. below or above cloud point temperatures ( T cp s) the copolymers, and under freezing condition, were utilized, affording with morphologies mechanical properties. At room temperature, transparent obtained through crosslinking among copolymer chains. Differently, opaque much improved properties formed at elevated thermally dehydrated collapsed aggregates, leading to heterogeneity for highly porous morphology. While temperature synergistically ice templating, these amphiphilic lamellar structures, which exhibited remarkable compressible as human articular cartilage excellent fatigue resistance. Amphiphilicity played a pivotal role in modulating network formation during gelation, well morphology performance resulting hydrogels. Through crosslinking, featured typical dynamic conformations transformed into unprecedently stabilized helicities due restrained chain mobilities three‐dimensional networks.

Language: Английский

Citations

0
How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges DOI Creative Commons
Jan Sobieraj, K. Strzelecka, Marcin Sobczak

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4607 - 4649

Published: May 1, 2024

Abstract: Cannabinoids are compounds found in and derived from the Cannabis plants that have become increasingly recognised as significant modulating factors of physiological mechanisms inflammatory reactions organism, thus inevitably affecting maintenance homeostasis. Medical popularity has surged since its legal regulation growing around world. Numerous promising discoveries bring more data on cannabinoids' pharmacological characteristics therapeutic applications. Given current surge interest medical use cannabinoids, there is an urgent need for effective method their administration. Surpassing low bioavailability, water solubility, instability became important milestone advancement cannabinoids pharmaceutical The numerous uses clinical practice remain restricted by limited administration alternatives, but hope when biodegradable polymers taken into account. primary objective this review to highlight wide range indications which may be used, well polymeric carriers enhance effectiveness. described a applications including pain management, neurological sleep disorders, anxiety, cancer treatment. these was further examined area dermatology cosmetology. Finally, with polymer-based drug delivery systems (DDSs), it demonstrated can delivered specifically intended site while also improving drug's physicochemical properties, emphasizing utility. Nevertheless, additional trials novel formulations required, full spectrum therapeutical potential yet unravelled. Keywords: systems, cannabidiol, tetrahydrocannabinol, polymers, nanomedicine

Language: Английский

Citations

0