Journal of Food Bioactives,
Journal Year:
2023,
Volume and Issue:
unknown, P. 43 - 52
Published: June 1, 2023
Ultraviolet
B
(UVB)-induced
cell
death
causes
skin
photoaging.
In
this
study,
we
investigated
the
protective
effect
of
Melanogrammus
aeglefinus
oligopeptide
(MSOP)
in
UVB-irradiated
human
keratinocytes.
The
method
preparing
MSOP
was
optimized,
and
three
peptides
with
high
abundance,
VADML
(Val-Ala-Asp-Met-Leu),
IARF
(Ile-Ala-Arg-Phe)
SSPSF
(Ser-Ser-Pro-Ser-Phe),
were
identified.
Discovery
Studio
predicted
that
these
interacted
Keap1
contributed
to
antioxidant
activity.
Therefore,
a
UVB-induced
model
used
explore
beneficial
effects
vitro.
activities
superoxide
dismutase
glutathione
peroxidase
increased
MSOP-treated
groups,
while
malondialdehyde
content
decreased.
addition,
23
differentially
expressed
proteins
identified
through
quantitative
proteomics
analysis;
among
them,
upregulation
Nrf2
downregulation
Keap1,
which
are
involved
Keap1/Nrf2/ARE
signaling
pathway,
process.
Based
on
might
be
an
alternative
agent
for
protecting
against
UVB
exposure.
Foods,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1774 - 1774
Published: June 5, 2024
Curcumin,
a
hydrophobic
polyphenol
extracted
from
the
rhizome
of
Curcuma
longa,
is
now
considered
candidate
drug
for
treatment
neurological
diseases,
including
Parkinson’s
Disease
(PD),
Alzheimer’s
(AD),
Huntington’s
(HD),
Multiple
Sclerosis
(MS),
Amyotrophic
Lateral
(ALS),
and
prion
disease,
due
to
its
potent
anti-inflammatory,
antioxidant
potential,
anticancerous,
immunomodulatory,
neuroprotective,
antiproliferative,
antibacterial
activities.
Traditionally,
curcumin
has
been
used
medicinal
dietary
purposes
in
Asia,
India,
China.
However,
low
water
solubility,
poor
stability
blood,
high
rate
metabolism,
limited
bioavailability,
little
capability
cross
blood–brain
barrier
(BBB)
have
clinical
application
curcumin,
despite
important
pharmacological
activities
this
drug.
A
variety
nanocarriers,
liposomes,
micelles,
dendrimers,
cubosome
nanoparticles,
polymer
solid
lipid
nanoparticles
developed
with
great
success
effectively
deliver
active
brain
cells.
Functionalization
on
surface
brain-specific
ligands
makes
them
target-specific,
which
should
significantly
improve
bioavailability
reduce
harmful
effects.
The
aim
review
summarize
studies
and/or
containing
most
common
neurodegenerative
highlighting
neuroprotective
potential
nutraceutical.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 31, 2025
Despite
the
diverse
applications
of
γ
radiation
in
radiotherapy,
industrial
processes,
and
sterilization,
it
causes
hazardous
effects
on
living
organisms,
such
as
cellular
senescence,
persistent
cell
cycle
arrest,
mitochondrial
dysfunction.
This
study
evaluated
efficacy
curcumin
nanoparticles
(CNPs)
mitigating
dysfunction
senescence
induced
by
rat
brain
tissues.
Four
groups
male
Wistar
albino
rats
(n
=
8
per
group)
were
included:
(Gr1)
control
group;
(Gr2)
CNPs
group
(healthy
receiving
oral
administration
at
a
dose
10
mg/kg/day,
three
times
week
for
eight
weeks);
(Gr3)
irradiated
(rats
exposed
to
single
Gy
head
irradiation);
(Gr4)
+
(irradiated
treated
with
CNPs).
The
data
obtained
demonstrated
that
weeks
attenuated
oxidative
stress
γ-irradiated
lowering
brain's
lipid
peroxidation
level
[malondialdehyde
(MDA)]
enhancing
antioxidant
markers
[superoxide
dismutase
(SOD),
reduced
glutathione
(GSH),
total
capacity
(TAC)]
(P
<
0.05).
In
addition,
significantly
increased
function
improving
complex
I,
II,
ATP
production
levels
compared
group.
rats,
also
showed
anti-neuroinflammatory
reducing
interleukin
6
(IL-6),
tumor
necrosis
factor-alpha
(TNF-α),
nuclear
factor-kappa
B
(NF-ĸB)
Moreover,
administered
β-galactosidase
activity
expression
p53,
p21,
p16
genes
0.05)
while
concurrently
inducing
significant
increase
AMPK
mRNA
conclusion,
ameliorated
neurotoxicity
hold
promise
novel
agent
delay
via
their
combined
antioxidant,
anti-inflammatory,
mitochondrial-enhancing
properties.
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(6), P. 4160 - 4172
Published: March 7, 2024
Abstract
Curcumin
is
known
for
its
antioxidant
properties.
This
study
aimed
to
investigate
the
impact
of
curcumin
on
acrylamide
(ACR)‐induced
alterations
in
first‐line
defense
ovarian
tissue.
Female
Balb/c
mice
were
divided
into
control,
ACR
(50
mg/kg),
ACR/CUR100
(received
Acr
+
curcumin100
and
ACR/CUR200
(Acr
200
mg/kg)
groups,
received
oral
treatments
35
days.
Evaluation
enzyme
expression
(
Sod
,
Cat
Gpx
genes),
pro‐apoptotic
gene
expressions
Bax
Caspase
3
),
anti‐apoptotic
Bcl2l1
)
at
mRNA
protein
levels
was
done.
Percentage
apoptotic
cells
using
Terminal
deoxynucleotidyl
transferase
dUTP
nick
end
labeling
(TUNEL)
assay
performed.
The
model
group
(ACR)
showed
decreased
genes
compared
with
control
group.
Treatment
two
different
doses
(CUR100
CUR200)
significantly
increased
expression,
CUR200
demonstrating
significant
recovery.
SOD,
CAT,
GPX
similar
trends,
administration.
Acrylamide
exposure
leading
a
notable
rise
apoptosis
as
Conversely,
administration,
reduced
expressions,
an
increase
Bcl2l1expression
though
not
statistically
significant.
TUNEL
revealed
substantial
decrease
curcumin‐received
groups.
In
our
study,
adversely
affected
thereby
markers.
Notably,
treatment
effectively
mitigated
these
effects,
restored
potential,
acrylamide‐induced
toxicity
female
mouse
ovaries.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(31), P. 4140 - 4147
Published: Jan. 1, 2024
Superoxide
dismutase
(SOD)
is
an
important
metalloenzyme
that
catalyzes
the
dismutation
of
superoxide
radicals
(O
2
˙
−
)
into
hydrogen
peroxide
(H
O
and
oxygen
).
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
15
Published: Dec. 19, 2023
Copper
(Cu)
plays
a
crucial
role
as
trace
element
in
various
physiological
processes
humans.
Nonetheless,
free
copper
ions
accumulate
the
brain
over
time,
resulting
range
of
pathological
changes.
Compelling
evidence
indicates
that
excessive
deposition
contributes
to
cognitive
decline
individuals
with
Alzheimer’s
disease
(AD).
Free
levels
serum
and
AD
patients
are
notably
elevated,
leading
reduced
antioxidant
defenses
mitochondrial
dysfunction.
Moreover,
accumulation
triggers
specific
form
cell
death,
namely
copper-dependent
death
(cuproptosis).
This
article
aimed
review
correlation
between
dysregulation
pathogenesis
AD,
along
primary
pathways
regulating
homoeostasis
copper-induced
AD.
Additionally,
efficacy
safety
natural
synthetic
agents,
including
chelators,
lipid
peroxidation
inhibitors,
antioxidants,
were
examined.
These
treatments
can
restore
equilibrium
prevent
cases.
Another
aim
this
was
highlight
significance
promote
development
pharmaceutical
interventions
address
it.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 7, 2025
Globally,
uveitis
is
a
collection
of
intraocular
inflammatory
disorders
that
affect
mainly
the
uvea,
resulting
in
irreversible
blindness
and
heavy
socioeconomic
burden.
Excessive
autoimmune
inflammation
oxidative
stress
are
major
drivers
contribute
to
initiation
progression
uveitis.
Nevertheless,
current
therapeutic
methods
for
limited
accompanied
by
several
serious
adverse
effects.
Recently,
nanotechnology-based
antioxidant
strategies
have
provided
novel
options
treatment
ocular
diseases.
Although
curcumin
(CUR)
has
prominent
capacity
reactive
oxygen
species
(ROS)
scavenging
ability,
its
low
bioavailability
undetermined
mechanisms
limit
extensive
application.
This
investigation
demonstrated
esterified
hyaluronic
acid-curcumin
nanoparticles
(HA-CUR
NPs)
with
superior
aqueous
dispersion
exhibited
exceptional
enzyme
mimetic
activity,
incorporating
superoxide
dismutase
(SOD),
glutathione
(GSH),
catalase
(CAT),
free
radical
ability.
Further
vitro
vivo
experimental
results
validated
protective
function
HA-CUR
NPs
against
stress-induced
damage
responses,
attenuated
pathological
progression,
relieved
microvascular
damage,
regulated
fundus
blood
flow
retinal
vascular
networks.
may
be
attributable
specific
ability
target
CD44
receptor
activate
Keap1/Nrf2/HO-1
signaling
pathway,
suggesting
potential
mechanism.
In
summary,
this
study
revealed
NPs,
which
composed
natural
product
biomacromolecules
outstanding
artificial
activities,
agents
effectively
safely
treating
other
ROS-related
