ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(1), P. 1207 - 1225
Published: Jan. 3, 2025
Manufacturing
bioactive
materials
for
drug
delivery
involves
developing
that
interact
with
biological
tissues
to
release
drugs
in
a
controlled
and
targeted
manner.
The
goal
is
optimize
therapeutic
efficacy
reduce
side
effects
by
combining
knowledge
from
engineering,
biology,
pharmacology.
This
study
presents
detailed
bibliometric
analysis,
exploring
the
keywords
"manufacturing,"
"bioactive
materials,"
"drug
delivery"
identify
highlight
significant
advancements
field.
From
Web
of
Science,
36,504
articles
were
analyzed,
171
selected
deeper
identifying
key
journals,
countries,
institutions,
authors.
results
field's
interdisciplinary
nature,
grouped
into
four
main
themes,
including
regenerative
medicine,
scaffolds,
three-dimensional
(3D)
printing,
glass,
tissue
engineering.
Future
research
this
area
will
focus
on
more
effective
precise
systems
using
technologies
like
3D
printing
nanotechnology
enhance
customization
control
release,
aiming
efficient
therapies.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1092 - 1092
Published: Sept. 6, 2024
Curcumin,
as
the
main
active
component
of
turmeric
(Curcuma
longa),
has
been
demonstrated
with
various
bioactivities.
However,
its
potential
therapeutic
applications
are
hindered
by
challenges
such
poor
solubility
and
bioavailability,
rapid
metabolism,
pan-assay
interference
properties.
Recent
advancements
have
aimed
to
overcome
these
limitations
developing
novel
curcumin
analogues
modifications.
This
brief
review
critically
assesses
recent
studies
on
synthesising
different
analogues,
including
metal
complexes,
nano
particulates,
other
derivatives,
focused
antioxidant,
anti-inflammatory,
anticancer
effects
modified
analogues.
Exploring
innovative
derivatives
offers
promising
strategies
address
associated
bioavailability
efficacy
valuable
insights
for
future
research
directions.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 108 - 108
Published: Jan. 14, 2025
Background/Objectives:
This
study
aims
to
evaluate
the
efficacy
of
curcumin
(CUR),
a
natural
polyphenol
with
potent
antimicrobial
and
anti-inflammatory
properties,
when
formulated
as
solid
lipid
nanoparticles
(CUR-loaded
SLN)
against
Enterococcus
faecalis.
Methods:
Solid
(SLNs)
were
prepared
carrier
for
CUR,
which
significantly
improved
its
solubility.
SLNs
made
cetyl
palmitate
Tween
80
obtained
via
hot
ultrasonication
method.
The
physicochemical
properties
CUR-loaded
evaluated,
including
their
size,
stability,
release
profile.
Antimicrobial
testing
was
conducted
both
sessile
planktonic
E.
faecalis
populations.
Cytotoxicity
assessed
on
human
gingival
fibroblasts.
Results:
exhibited
about
200
nm
−25
mV
surface
potential,
encapsulation
CUR
did
not
affect
SLNs.
CURs
released
from
in
controlled
sustained
manner
over
100
h.
remained
stable
at
least
two
months
stored
4
°C
or
25
°C,
making
them
suitable
clinical
use.
Antioxidant
activity
confirmed
through
DPPH
ABTS
assays.
Free
reduced
CFU
counts
by
approximately
65%
after
24
h
exposure.
However,
this
inhibitory
effect
diminished
longer
exposure
times
(48
72
h).
studies
showed
dose-
time-dependent
effects,
2.5–10
µg/mL
range,
populations,
good
cytocompatibility
fibroblasts
up
2.5
μg/mL,
suggesting
low
toxicity.
Conclusions:
demonstrate
significant
faecalis,
along
cytocompatibility,
indicating
potential
an
effective
adjunct
therapy
endodontic
treatments.
Curcumin,
as
the
main
active
component
of
Turmeric
(Curcuma
Longa),
has
been
demonstrated
with
various
bioactivities.
However,
its
potential
therapeutic
applications
are
hindered
by
challenges
such
poor
solubility
and
bioavailability,
rapid
metabolism,
pan-assay
interference
properties.
Recent
advancements
have
aimed
to
overcome
these
limitations
developing
novel
curcumin
analogues
modifications.
This
brief
review
critically
assesses
recent
studies
on
synthesising
different
analogues,
including
metal
complexes,
nano
particulates,
other
derivatives,
focused
antioxidant,
anti-inflammatory,
anticancer
effects
modified
analogues.
Exploring
innovative
derivatives
offers
promising
strategies
address
associated
bioavailability
efficacy
valuable
insights
for
future
research
directions.
Inflammopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Across
diverse
cultures,
herbal
remedies
have
been
used
to
alleviate
oral
discomfort
and
maintain
dental
hygiene.
This
review
presents
studies
on
with
remarkable
antimicrobial,
anti-inflammatory,
antioxidant,
anticancer,
anticaries,
analgesic,
healing
properties.
The
manuscripts
demonstrate
the
depth
of
scientific
inquiry
into
for
management
various
health
conditions.
These
include
gingivitis,
ulcers,
mucositis,
periodontitis,
pathogens,
carcinoma,
xerostomia,
caries.
Researchers
investigated
phytochemical
pharmacological
properties
plant-derived
compounds
their
extracts
evaluated
interactions
pathogens
inflammatory
processes.
convergence
traditional
knowledge
rigorous
investigation
offers
a
compelling
narrative,
fostering
deeper
understanding
as
viable
alternatives
conventional
interventions.
work
has
potential
provide
patients
access
gentle,
yet
effective
solutions,
simultaneously
offer
professionals
opportunity
enrich
knowledge,
ability
personalized,
holistic
care.
highlights
symbiotic
relationship
between
medicine
understanding,
emphasizing
importance
disseminating
this
benefit
both
practitioners
patients,
enabling
evidence-based
decision-making
in
exploration
promising
alternative,
potentially
mitigating
some
these
side
effects
while
promoting
more
natural
manner.
Journal of Oral Microbiology,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: March 6, 2025
Enterococcus
faecalis
(E.
faecalis),
the
main
pathogenic
bacterium
of
root
canal
infection,
can
penetrate
deep
into
dentin
tubule,
form
a
biofilm,
and
resist
host
defense
mechanisms,
thereby
increasing
treatment
complexity.
Therefore,
key
to
infections
is
completely
kill
bacteria
prevent
secondary
infection.
This
review
assesses
advancements
in
traditional
novel
disinfection
methods
targeting
E.
biofilm.
By
comparing
bactericidal
mechanisms
effects
individual
combined
application
these
methods,
scientific
basis
clinical
potential
as
adjuvant
or
alternative
treatments
were
evaluated
for
optimization
strategy
was
provided.
Emerging
strategies,
including
natural
medicine,
antibacterial
photodynamic
therapy,
cold
atmospheric
plasma,
have
shown
promising
effects.
These
approaches
replace
offering
more
effective
solutions
pulp
treatment.
Gels,
Journal Year:
2025,
Volume and Issue:
11(5), P. 308 - 308
Published: April 22, 2025
Intracanal
reinfections
continue
to
pose
a
major
challenge
in
endodontic
treatment.
Photodynamic
therapy
has
emerged
as
promising
antimicrobial
strategy.
Regarding
this,
curcumin
(CUR),
natural
photosensitizer,
shows
potential
this
context,
but
its
application
is
hampered
by
poor
solubility
and
rapid
degradation.
This
study
aimed
develop
characterize
CUR-loaded
nanoparticle-enriched
hydrogel
enhance
stability,
sustain
release,
evaluate
efficacy
upon
photoactivation
(PhAc).
Curcumin-loaded
nanoparticles
were
synthesized
incorporated
into
matrix,
followed
characterization
using
scanning
electron
microscopy,
Fourier-transform
infrared
spectroscopy,
vitro
CUR
release
studies,
rheological
analysis.
Antibiofilm
activity
against
Enterococcus
faecalis
was
assessed
under
both
photoactivated
non-photoactivated
conditions.
Cytocompatibility
analyzed
through
fibroblast
viability
assays
fluorescence
staining.
The
CUR-containing
demonstrated
sustained
profile
extending
beyond
72
h.
Rheological
studies
confirmed
shear-thinning
behavior,
ensuring
injectability
even
after
post-photoactivation.
revealed
significant
reduction
E.
biofilms,
with
PhAc
formulations
exhibiting
markedly
enhanced
antibacterial
compared
their
non-PhAc
counterparts.
that
all
formulations,
including
those
subjected
PDT,
preserved
viability,
indicating
biocompatibility
suitable
for
clinical
use.
In
sum,
the
exhibits
properties
support
an
effective
intracanal
therapeutic,
combining
photodynamic
effects
help
prevent
treatments.
