Journal of Food Bioactives,
Journal Year:
2023,
Volume and Issue:
unknown, P. 43 - 52
Published: June 1, 2023
Ultraviolet
B
(UVB)-induced
cell
death
causes
skin
photoaging.
In
this
study,
we
investigated
the
protective
effect
of
Melanogrammus
aeglefinus
oligopeptide
(MSOP)
in
UVB-irradiated
human
keratinocytes.
The
method
preparing
MSOP
was
optimized,
and
three
peptides
with
high
abundance,
VADML
(Val-Ala-Asp-Met-Leu),
IARF
(Ile-Ala-Arg-Phe)
SSPSF
(Ser-Ser-Pro-Ser-Phe),
were
identified.
Discovery
Studio
predicted
that
these
interacted
Keap1
contributed
to
antioxidant
activity.
Therefore,
a
UVB-induced
model
used
explore
beneficial
effects
vitro.
activities
superoxide
dismutase
glutathione
peroxidase
increased
MSOP-treated
groups,
while
malondialdehyde
content
decreased.
addition,
23
differentially
expressed
proteins
identified
through
quantitative
proteomics
analysis;
among
them,
upregulation
Nrf2
downregulation
Keap1,
which
are
involved
Keap1/Nrf2/ARE
signaling
pathway,
process.
Based
on
might
be
an
alternative
agent
for
protecting
against
UVB
exposure.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 28, 2025
Developing
treatments
for
age-related
diseases
requires
cost-effective
and
efficient
approaches.
Nutrients
natural
metabolites
offer
safer
alternatives
to
synthetic
drugs.
Aging
increases
the
need
solutions
that
protect
health
repair
cells.
Recent
studies
show
nutrients
products
reduce
oxidative
stress,
regulate
metabolism,
influence
longevity-related
genes.
This
review
focuses
on
vitamins,
minerals,
antioxidants,
improve
healthspan
combat
aging.
It
also
discusses
challenges
such
as
standardization,
clinical
validation,
regulatory
approval.
Finally,
emerging
trends,
personalized
nutrition
advanced
delivery
systems,
highlight
potential
of
these
addressing
Applied Biosciences,
Journal Year:
2025,
Volume and Issue:
4(2), P. 23 - 23
Published: May 2, 2025
Experimental
research
demands
the
selection
of
appropriate
models
to
align
with
study
objectives
and
conditions.
Traditional
experimental
models,
such
as
in
vivo
animal
studies
vitro
systems
like
organoids,
present
nutraceutical
pharmaceutical
limitations
high
cost,
ethical
concerns,
long
lifespan,
difficult
genetic
manipulation.
Caenorhabditis
elegans
has
proved
be
a
valuable
model
result
its
physiological
similarities
higher
organisms,
fully
sequenced
genome,
short
life
cycle,
transparency.
These
features
enable
high-throughput
screening,
molecular
pathway
analysis,
lifespan
healthspan
assays.
C.
significantly
advanced
discovery
bioactive
molecules
therapeutic
potential,
shedding
light
on
aging,
neurodegeneration,
metabolic
disorders,
immune
responses.
Its
utility
pharmacokinetics
validation
nutraceuticals
underscores
role
longevity
health
research.
Additionally,
conserved
stress
response,
apoptosis,
pathogen
recognition
pathways
facilitate
pharmacological
interventions
for
inflammation,
oxidative
stress,
infections.
This
evaluates
applicability
analyses
drug
efficacy
testing,
discusses
relevant
advancements,
associated
difficulties,
what
expect
Canadian Respiratory Journal,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Background
.
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
common
respiratory
disease.
Currently,
no
specific
treatment
strategy
has
been
established;
therefore,
finding
new
methods
essential.
Clinically,
Shenqi
Huatan
Decoction
(SQHT)
traditional
Chinese
medicinal
formula
for
COPD
treatment;
however,
its
mechanism
of
action
in
needs
to
be
clarified.
Methods
The
rat
model
was
replicated
by
cigarette
smoking
and
tracheal
injection
using
the
LPS
method.
control
group
SQHT
groups
were
treated
with
dexamethasone
gavage,
respectively.
After
treatment,
superoxide
dismutase
(SOD)
serum
levels,
total
antioxidant
capacity
(TAOC),
lipid
peroxidation,
malondialdehyde
(MDA)
detected
enzyme‐linked
immunosorbent
assay
(ELISA).
Activated
protein
kinase
alpha
(AMPK‐
α
),
forkhead
transcription
factor
O3a
(FOXO3a),
manganese
SOD
(MnSOD),
peroxisome
proliferator‐activated
receptor
gamma
(PPAR
γ
)
reverse
transcriptase
quantitative
polymerase
chain
reaction
(RT‐qPCR)
Western
blot.
Microribonucleic
acid
expression
levels
measured,
pathological
changes
lung
tissue
observed
hematoxylin
eosin
staining.
Results
findings
suggested
that
substantially
affects
enhancing
alveolar
fusion
reducing
emphysema.
ELISA
results
showed
could
lower
blood
MDA
peroxide
raise
TAOC
suggesting
it
lessen
oxidative
stress.
In
rats
COPD,
large
doses
intervention
dramatically
increased
AMPK
expression,
AMPK‐
,
FOXO3a,
MnSOD,
PPAR
indicating
may
reduce
stress
activating
‐mediated
AMPK/FOXO3a
signaling
pathway.
Similar
obtained
RT‐qPCR.
Conclusion
effective
treatment.
related
activation
pathway
improve
tissue.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1272 - 1272
Published: Sept. 29, 2024
Research
has
shown
the
multiple
actions
of
curcumin
on
different
cell
systems,
including
enzymes
and
mitochondria.
The
detected
effects
mitochondria
are
diverse,
ranging
from
protective
to
toxic.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6559 - 6559
Published: June 14, 2024
Curcumin,
a
polyphenol
derived
from
Curcuma
longa,
used
as
dietary
spice,
has
garnered
attention
for
its
therapeutic
potential,
including
antioxidant,
anti-inflammatory,
and
antimicrobial
properties.
Despite
known
benefits,
the
precise
mechanisms
underlying
curcumin’s
effects
on
consumers
remain
unclear.
To
address
this
gap,
we
employed
genetic
model
Drosophila
melanogaster
leveraged
two
omics
tools—transcriptomics
metabolomics.
Our
investigation
revealed
alterations
in
1043
genes
73
metabolites
upon
supplementing
curcumin
into
diet.
Notably,
observed
modulation
pathways
related
to
antioxidants,
carbohydrates,
lipids,
well
associated
with
gustatory
perception
reproductive
processes.
Metabolites
implicated
carbohydrate
metabolism,
amino
acid
biosynthesis,
biomarkers
linked
prevention
of
neurodegenerative
diseases
such
schizophrenia,
Alzheimer’s,
aging
were
also
identified.
The
study
highlighted
strong
correlation
between
diet,
antioxidant
mechanisms,
metabolism.
Conversely,
lower
was
metabolism
cholesterol
biosynthesis.
This
research
highlights
impact
influencing
perception,
fertility,
molecular
wellness.
Furthermore,
it
directs
future
studies
toward
more
focused
exploration
specific
consumption.
Journal of Food Bioactives,
Journal Year:
2023,
Volume and Issue:
unknown, P. 43 - 52
Published: June 1, 2023
Ultraviolet
B
(UVB)-induced
cell
death
causes
skin
photoaging.
In
this
study,
we
investigated
the
protective
effect
of
Melanogrammus
aeglefinus
oligopeptide
(MSOP)
in
UVB-irradiated
human
keratinocytes.
The
method
preparing
MSOP
was
optimized,
and
three
peptides
with
high
abundance,
VADML
(Val-Ala-Asp-Met-Leu),
IARF
(Ile-Ala-Arg-Phe)
SSPSF
(Ser-Ser-Pro-Ser-Phe),
were
identified.
Discovery
Studio
predicted
that
these
interacted
Keap1
contributed
to
antioxidant
activity.
Therefore,
a
UVB-induced
model
used
explore
beneficial
effects
vitro.
activities
superoxide
dismutase
glutathione
peroxidase
increased
MSOP-treated
groups,
while
malondialdehyde
content
decreased.
addition,
23
differentially
expressed
proteins
identified
through
quantitative
proteomics
analysis;
among
them,
upregulation
Nrf2
downregulation
Keap1,
which
are
involved
Keap1/Nrf2/ARE
signaling
pathway,
process.
Based
on
might
be
an
alternative
agent
for
protecting
against
UVB
exposure.
