Clinical Cancer Investigation Journal, Journal Year: 2024, Volume and Issue: 13(4), P. 7 - 14
Published: Jan. 1, 2024
Language: Английский
Biology, Journal Year: 2024, Volume and Issue: 13(5), P. 307 - 307
Published: April 28, 2024
Cancer immune evasion represents a leading hallmark of cancer, posing significant obstacle to the development successful anticancer therapies. However, landscape cancer treatment has significantly evolved, transitioning into era immunotherapy from conventional methods such as surgical resection, radiotherapy, chemotherapy, and targeted drug therapy. Immunotherapy emerged pivotal component in treatment, harnessing body’s system combat offering improved prognostic outcomes for numerous patients. The remarkable success spurred efforts enhance clinical efficacy existing agents strategies. Several immunotherapeutic approaches have received approval treatments, while others are currently preclinical trials. This review explores recent progress unraveling mechanisms evaluates effectiveness diverse strategies, including vaccines, adoptive cell therapy, antibody-based treatments. It encompasses both established treatments those under investigation, providing comprehensive overview through immunological approaches. Additionally, article emphasizes current developments, limitations, challenges immunotherapy. Furthermore, by integrating analyses resistance exploring combination strategies personalized approaches, it offers valuable insights crucial novel
Language: Английский
Citations
9
Vaccines, Journal Year: 2025, Volume and Issue: 13(1), P. 64 - 64
Published: Jan. 13, 2025
Background: In the past decade, immunotherapy has become a major choice for treatment of lung cancer, yet its therapeutic efficacy is still relatively limited due to various immune escape mechanisms tumors. Based on this, we introduce Neo-BCV, novel bacterial composite vaccine designed enhance responses against cancer. Methods: We investigated enhancing effect Neo-BCV through in vivo and vitro experiments, including flow cytometry, RNA-seq, Western blot. Results: have demonstrated that can promote Dendritic cells (DCs) maturation induce DCs differentiation into pro-inflammatory subgroups, significantly cytotoxic T lymphocyte (CTL)-mediated anti-tumor responses. Transcriptome sequencing revealed exerts effects by specifically inhibiting JAK2-STAT3 signaling pathway, crucial regulator cancer progression, metabolism, inflammation. Moreover, improved microenvironment both tumor spleen tissues without inducing notable toxic organs. Conclusions: These findings highlight Neo-BCV’s potential as safe effective strategy, offering avenue clinical translation immunotherapy.
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119386 - 119386
Published: Jan. 1, 2025
Language: Английский
Citations
0
Open Life Sciences, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 1, 2025
Abstract This study was to analyze the effect of triptolide (TPL) on proliferation, apoptosis, and relationship between TPL Janus kinase/signal transducer activator transcription signaling pathway in hepatoma cells. HepG2 cell line selected as experimental object divided into control, low-dose TPL, medium-dose high-dose group. The control group did not receive any drug treatment, while low, medium, groups were treated with at concentrations 0.02, 0.05, 0.10 μM, respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, flow cytometry, western blot used detach mechanism. proliferation inhibition rate each dose lower than that group, increased increase ( P < 0.05). apoptosis higher expression phosphorylated kinase 1 (p-JAK1) signal 3 (p-STAT3) protein cells p-JAK1 p-STAT3 decreased 10 ng/mL transforming growth factor-beta + reduced activity B-cell lymphoma/leukemia-2-associated X (Bax) cysteine aspartic acid protease (Caspase)-3/9 raised lymphoma/leukemia-2 (Bcl-2) With dose, Bax Caspase-3/9 increased, Bcl-2 As an anti-liver cancer agent, inhibits hepatocellular carcinoma promotes apoptosis. mechanism may involve inhibiting 1/signal activation apoptosis-related pathways.
Language: Английский
Citations
0
Journal of Clinical Personalized Medicine, Journal Year: 2025, Volume and Issue: 04(02), P. 767 - 774
Published: Jan. 1, 2025
Language: Английский
Citations
0
Cardiovascular Diagnosis and Therapy, Journal Year: 2024, Volume and Issue: 14(6), P. 1186 - 1201
Published: Nov. 21, 2024
Interleukin-6 (IL-6) plays multifaceted roles in cancer and atherosclerosis. Initially recognized for its role immune response inflammation, IL-6 promotes tumor progression via the JAK-STAT MAP kinase pathways is associated with poor prognoses. In atherosclerosis, contributes to endothelial dysfunction plaque formation. This review highlights shared inflammatory mechanisms of both diseases explores regulatory dynamics signaling, including gene polymorphisms epigenetic modifications. Google Scholar, Scopus, PubMed were searched English-language articles on those reporting pathogenic atherosclerosis from their inception through June 2024. The investigation into IL-6's reveals intricate interconnected nature processes chronic diseases. conditions underscores centrality disease pathology, particularly involvement modulation, cellular proliferation. commonality as a key player linking these seemingly distinct Given mechanism this narrative concludes by emphasizing therapeutic potential modulating treating It advocates personalized treatment strategies that combine targeted therapies lifestyle holistic approach considered crucial effective management, given diverse complex widespread conditions.
Language: Английский
Citations
3
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155408 - 155408
Published: June 13, 2024
Language: Английский
Citations
2
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Nov. 26, 2024
Colorectal cancer (CRC) remains one of the most prevalent and fatal malignancies worldwide, consistently ranking among top three in terms incidence mortality. Despite notable advancements early detection therapeutic interventions, survival outcomes for advanced-stage CRC are still dismal, largely due to issues such as drug resistance metastasis. Recent research has increasingly implicated JAK-STAT signaling pathway a pivotal contributor pathogenesis. This evolutionarily conserved plays key role transmitting extracellular signals nucleus, thereby modulating gene expression involved numerous fundamental biological processes. In CRC, dysregulation is frequently observed strongly associated with tumor progression, including processes cellular proliferation, apoptosis, metastasis, immune evasion, sustenance stem cells. Given its integral advancement, gained recognition viable target. Extensive evidence from preclinical clinical models supports efficacy safety targeting components pathway, presenting new possibilities patients particularly addressing enhancing treatment outcomes. review offers detailed exploration focusing on regulatory mechanisms CRC-related malignancies. Moreover, it examines association between protein expression, features, prognosis, potential management.
Language: Английский
Citations
2
Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4293 - 4293
Published: Sept. 10, 2024
In this study, we hypothesized that biotinylated and/or glycidol-flanked fourth-generation polyamidoamine (PAMAM G4) dendrimers could be a tool for efficient drug transport into glioma and liver cancer cells. For purpose, native PAMAM (G4) dendrimers, (G4B), glycidylated (G4gl), (G4Bgl), were synthesized, their cytotoxicity, uptake, accumulation in vitro vivo studied relation to the mediated by sodium-dependent multivitamin transporter (SMVT). The studies showed human temozolomide-resistant cell line (U-118 MG) hepatocellular carcinoma (HepG2) indicated higher amount of SMVT than HaCaT keratinocytes (HaCaTs) used as model normal G4gl G4Bgl highly biocompatible (they did not affect proliferation mitochondrial activity) against U-118 MG cells (against
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 21, 2024
In recent years, cancer, especially primary liver cancer (including hepatocellular carcinoma and intrahepatic cholangiocarcinoma), has posed a serious threat to human health. the field of exosomes play an important role in initiation, metastasis interaction with tumor microenvironment. Exosomes are class nanoscale extracellular vesicles (EVs)secreted by most cells rich bioactive molecules, including RNA, proteins lipids, that mediate intercellular communication during physiological pathological processes. This review reviews multiple roles progression, as well their effects on angiogenesis, epithelial-mesenchymal transformation (EMT), immune evasion, drug resistance. have great potential biomarkers for diagnosis prognosis because they carry specific molecular markers facilitate early detection evaluation treatment outcomes. addition, exosomes, new type delivery vector, unique advantages targeted therapy provide strategy cancer. The challenges prospects exosome-based immunotherapy were also discussed. However, such standardization isolation techniques scalability therapeutic applications remain significant hurdles.
Language: Английский
Citations
1