Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(3), P. 751 - 756
Published: Jan. 12, 2024
A
highly
diastereoselective
[3
+
2]
cycloaddition
of
aziridines
with
difluorinated
silyl
enol
ethers
has
been
developed.
This
approach
provides
a
facile
methodology
for
functionalized
gem-difluorinated
pyrrolidines
in
good
to
excellent
yields
functional
group
tolerance.
one-pot,
two-step
synthesis
structurally
interesting
fluorinated
pyrroles
also
developed
through
cycloaddition/aromatization/desulfonation
sequence.
Moreover,
readily
available
substrates,
mild
reaction
conditions,
and
easy
scale-up
show
practical
advantages.
Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
29(42)
Published: May 26, 2023
Abstract
(Hetero)arenes
continue
to
prove
their
indispensability
in
pharmaceuticals,
materials
science,
and
synthetic
chemistry.
As
such,
the
controllable
modification
of
biologically
significant
(hetero)arenes
towards
diverse
more‐potent
complex
molecular
scaffolds
through
peripheral
skeletal
editing
has
been
considered
a
challenging
goal
organic
Despite
many
excellent
reviews
on
(
i.
e
.,
C−H
functionalization)
(hetero)arenes,
editings
via
single
atom
insertion,
deletion,
or
transmutations
have
received
less
attention
review
literature.
In
this
review,
we
systematically
summarize
state‐of‐the‐art
reactions
using
carbenes,
with
focus
general
mechanistic
considerations
applications
natural
product
syntheses.
The
potential
opportunities
inherent
challenges
encountered
while
developing
these
strategies
are
also
highlighted.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 6, 2023
To
overcome
numerous
health
disorders,
heterocyclic
structures
of
synthetic
or
natural
origin
are
utilized,
and
notably,
the
emergence
various
side
effects
existing
drugs
used
for
treatment
resistance
disease-causing
microorganisms
renders
ineffective.
Therefore,
discovery
potential
therapeutic
agents
that
utilize
different
modes
action
is
utmost
significance
to
circumvent
these
constraints.
Pyrrolidines,
pyrrolidine-alkaloids,
pyrrolidine-based
hybrid
molecules
present
in
many
products
pharmacologically
important
agents.
Their
key
roles
pharmacotherapy
make
them
a
versatile
scaffold
designing
developing
novel
biologically
active
compounds
drug
candidates.
This
review
aims
provide
an
overview
recent
advancements
(especially
during
2015-2023)
exploration
pyrrolidine
derivatives,
emphasizing
their
as
fundamental
components
skeletal
structure.
In
contrast
previous
reviews
have
predominantly
focused
on
singular
biological
activity
associated
with
molecules,
this
consolidates
findings
from
investigations
encompassing
wide
range
activities
(antimicrobial,
antiviral,
anticancer,
anti-inflammatory,
anticonvulsant,
cholinesterase
inhibition,
carbonic
anhydrase
inhibition)
exhibited
by
derivatives.
study
also
anticipated
serve
valuable
resource
research
development
endeavors,
offering
significant
insights
guidance.
Future Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 19
Published: March 19, 2025
TB
drug
discovery
needs
scientists'
attention
since
resistance
in
TB,
including
extensively
drug-resistant
(XDR-TB)
and
multidrug-resistant
(MDR-TB),
is
a
major
healthcare
concern.
Since
millions
of
fatalities
from
tuberculosis
are
recorded
each
year,
there
an
urgent
need
to
discover
new
anti-tubercular
medications
that
will
either
eradicate
or
control
the
disease.
Spiro
compounds
have
garnered
lot
medicinal
chemistry
these
days
because
various
biological
activities
mainly
their
adaptability
structural
resemblance
significant
pharmacophores.
This
article
overviews
synthesis
activity
spirocyclic
as
agents.
Both
synthesized
naturally
occurring
spiro
chemicals
exhibit
antitubercular
properties.
The
promising
potential
shown
by
some
has
attracted
scientists
explore
them
further
develop
molecules
with
improved
pharmacodynamic
pharmacokinetic
properties
mechanisms
action
enhanced
safety
efficacy
tuberculosis.
current
review
covers
exploration
year
2004
2024
for
combat
Tuberculosis.
gives
comprehensive
advancements
this
scaffold
which
would
help
logical
design
powerful,
less
toxic,
more
effective
anti-TB
molecules.
Polycyclic aromatic compounds,
Journal Year:
2022,
Volume and Issue:
43(5), P. 4333 - 4345
Published: June 23, 2022
Quinoline
heterocycles
have
been
considered
important
structures
due
to
their
diverse
applications
in
organic
synthesis,
coordination
chemistry,
as
well
the
fields
of
drug
design
and
development.
Consequently,
many
researchers
around
globe
focused
on
production
these
molecules
objective
lead
compounds
exploit
biological
activities.
Herein,
presented
review
provides
an
overview
anticancer
agents
natural
sources
quinolines
includes
a
summary
marketed
drugs.
Advanced
synthetic
analogs
quinoline
derivatives
activity
provided.
