A Review on Molecular Iodine Catalyzed/Mediated Multicomponent Reactions DOI

Monika,

Chander Chander,

Sita Ram

et al.

Asian Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 26, 2022

Abstract In multicomponent reactions, three or more reactants combine in one pot to form a product without the isolation of intermediate and most contribute newly formed reducing number steps involved waste generated. Molecular iodine is mild, efficient, relatively nontoxic, inexpensive, commercially available, catalyzes various organic reactions due its Lewis acidic behaviour. The development catalyzed by molecular indeed good green alternative for synthetic chemistry. aim this article review all important reported since 2013 order envisage some new efficient protocols synthesis structurally complex molecules.

Language: Английский

Skeletal Editing of (Hetero)Arenes Using Carbenes DOI
Zhaohong Liu, Paramasivam Sivaguru, Yongquan Ning

et al.

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(42)

Published: May 26, 2023

Abstract (Hetero)arenes continue to prove their indispensability in pharmaceuticals, materials science, and synthetic chemistry. As such, the controllable modification of biologically significant (hetero)arenes towards diverse more‐potent complex molecular scaffolds through peripheral skeletal editing has been considered a challenging goal organic Despite many excellent reviews on ( i. e ., C−H functionalization) (hetero)arenes, editings via single atom insertion, deletion, or transmutations have received less attention review literature. In this review, we systematically summarize state‐of‐the‐art reactions using carbenes, with focus general mechanistic considerations applications natural product syntheses. The potential opportunities inherent challenges encountered while developing these strategies are also highlighted.

Language: Английский

Citations

75
Recent insights about pyrrolidine core skeletons in pharmacology DOI Creative Commons
Samet Poyraz, H. Ali Döndaş, Naciye Yaktubay Döndaş

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 6, 2023

To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence various side effects existing drugs used for treatment resistance disease-causing microorganisms renders ineffective. Therefore, discovery potential therapeutic agents that utilize different modes action is utmost significance to circumvent these constraints. Pyrrolidines, pyrrolidine-alkaloids, pyrrolidine-based hybrid molecules present in many products pharmacologically important agents. Their key roles pharmacotherapy make them a versatile scaffold designing developing novel biologically active compounds drug candidates. This review aims provide an overview recent advancements (especially during 2015-2023) exploration pyrrolidine derivatives, emphasizing their as fundamental components skeletal structure. In contrast previous reviews have predominantly focused on singular biological activity associated with molecules, this consolidates findings from investigations encompassing wide range activities (antimicrobial, antiviral, anticancer, anti-inflammatory, anticonvulsant, cholinesterase inhibition, carbonic anhydrase inhibition) exhibited by derivatives. study also anticipated serve valuable resource research development endeavors, offering significant insights guidance.

Language: Английский

Citations

28
Exploration of Indolo[3,2c]isoquinoline derived triazoles as potential antimicrobial and DNA cleavage agents: Synthesis, DFT calculations, and molecular modeling studies DOI

Suliphuldevarada Mathada Basavarajaiah,

Jaishree Badiger,

Nagesh Gunavanthrao Yernale

et al.

Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 137, P. 106598 - 106598

Published: May 9, 2023

Language: Английский

Citations

25
Carbon-based catalysts: advances in synthesizing N-heterocyclic compounds using graphene family and graphite oxide DOI
Parvin Beigiazaraghbelagh, Ahmad Poursattar Marjani

Research on Chemical Intermediates, Journal Year: 2024, Volume and Issue: 50(2), P. 485 - 531

Published: Jan. 5, 2024

Language: Английский

Citations

12
Antimicrobial, antioxidant, cell imaging and sensing applications of fluorescein derivatives: A review DOI

Amani H. Alharbi,

Sikandar Khan

Analytical Biochemistry, Journal Year: 2024, Volume and Issue: 688, P. 115479 - 115479

Published: Feb. 9, 2024

Language: Английский

Citations

11
Synthesis of pyrrole-heterocyclic derivatives as anti-Alzheimer and antidiabetic candidates: An in vitro-in silico study DOI
О. В. Петрова, Denis N. Tomilin, Halil Şenol

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1315, P. 138998 - 138998

Published: June 14, 2024

Language: Английский

Citations

10
Investigating the molecular interactions of 11-substituted-1-(4-chlorophenyl)-8H-indolo[3,2-c][1,2,4]triazolo[3,4-a]isoquinolines for Antimicrobial Potential: Synthesis, Spectral, In vitro and In silico study interpretations DOI

B. T. Sridhar,

Mohammad Javeed,

Prashantha Karunakar

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138617 - 138617

Published: May 12, 2024

Language: Английский

Citations

8
Binding Thermodynamics of 1,3-bis(((E-1H-pyrrol-2-yl) methylene) amino) propan-2-ol palladium(II) with HSA and Its Intercalative Behaviour in ctDNA DOI Creative Commons
Sheldon Sookai,

Ayanda Majoka,

Manuel A. Fernandes

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1334, P. 141880 - 141880

Published: Feb. 26, 2025

Language: Английский

Citations

1
Spirocyclic compounds: potential drug leads in the fight against Mycobacterium tuberculosis DOI

Pardeep Kumar,

Anuradha Singampalli,

Rani Bandela

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: March 19, 2025

TB drug discovery needs scientists' attention since resistance in TB, including extensively drug-resistant (XDR-TB) and multidrug-resistant (MDR-TB), is a major healthcare concern. Since millions of fatalities from tuberculosis are recorded each year, there an urgent need to discover new anti-tubercular medications that will either eradicate or control the disease. Spiro compounds have garnered lot medicinal chemistry these days because various biological activities mainly their adaptability structural resemblance significant pharmacophores. This article overviews synthesis activity spirocyclic as agents. Both synthesized naturally occurring spiro chemicals exhibit antitubercular properties. The promising potential shown by some has attracted scientists explore them further develop molecules with improved pharmacodynamic pharmacokinetic properties mechanisms action enhanced safety efficacy tuberculosis. current review covers exploration year 2004 2024 for combat Tuberculosis. gives comprehensive advancements this scaffold which would help logical design powerful, less toxic, more effective anti-TB molecules.

Language: Английский

Citations

1
Synthesis, spectral analysis, DFT calculations, biological potential and molecular docking studies of indole appended pyrazolo-triazine DOI

S. M. Basavarajaiah,

Nagesh Gunavanthrao Yernale,

Mohammad Javeed

et al.

Molecular Diversity, Journal Year: 2022, Volume and Issue: 27(2), P. 679 - 693

Published: May 10, 2022

Language: Английский

Citations

37