6,7-Coumarin-heterocyclic hybrids: A comprehensive review of their natural sources, synthetic approaches, and bioactivity

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1303, P. 137601 - 137601

Published: Jan. 22, 2024

Language: Английский

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Coumarin hybrids for targeted therapies: A promising approach for potential drug candidates

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 60, P. 117 - 133

Published: Feb. 8, 2024

Language: Английский

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Biocompatible chlorocoumarins from harmful chlorophenols, their synthesis and biomedicinal evaluation

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1309, P. 138193 - 138193

Published: March 30, 2024

Language: Английский

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4-Chloroskimmetine-based derivatives as potential anticancer and antibacterial prospects: Their synthesis and in vitro inspections

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101511 - 101511

Published: Jan. 1, 2024

Cancer and bacterial infections are among the most high-interest health threats facing humanity. The growing resistance to current-found anticancer antibacterial drugs necessitates exploration of new, effective agents. To synthesize some them, 4-chloroskimmetine (4-CSM), with undefined biological effects, was used as a building block create thirteen its derived coumarins. This precursor Bargellini reaction were produce first coumarin, designated Y0. From which, twelve coumarins coded Y1-Y12 created by esterifying Y0 various halophenols using SOCl2-promoted reaction. FTIR, 1HNMR, 13CNMR spectra analyzed ascertain chemical framework Their potential function prospects evaluated against six cancer-derived populations employing preliminary MTT-facilitated methodology. These MCF-7, HeLa, SKG, AMN3, SK-OV-3, KYSE-30. On other hand, broth microdilution protocol followed specify activity high-infective aerobes. include Pseudomonas aeruginosa, Shigella dysenteriae, Haemophilus influenza, Klebsiella pneumonia, Escherichia coli, Salmonella typhi. results evaluation indicated that presence fluoride on off-side aromatic ring afforded potent activity, Y5 best. For second same findings true, but when halogen is chloride Y2 superior one. authors concluded 4-CSM, can be exploited bioactive activities. Also, considered promising structural templates for producing medications, respectively.

Language: Английский

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Food-Derived Micronutrients as Alleviators of Age-Related Dysfunction: A Dive into Their Effects and Cellular Mechanisms

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

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Coumarins derived from natural methoxystilbene as oxidative stress-related disease alleviators: Synthesis and in vitro-in silico study

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1302, P. 137471 - 137471

Published: Dec. 31, 2023

Language: Английский

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Triple coumarin-based 5-fluorouracil prodrugs, their synthesis, characterization, and release kinetics

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1301, P. 137415 - 137415

Published: Dec. 26, 2023

Language: Английский

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Nutraceutical-based telomerase inhibitors: Renewed hope for cancer therapy

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(2), P. 100537 - 100537

Published: Feb. 20, 2024

: Attributes of potential targets for anticancer therapy are currently being investigated telomeres, telomerase, and their combined complex. Telomerase (TRTase) is a distinct reverse transcriptase that thought to be the leader in almost all cancer-derived cells primarily charge controlling telomere (TLM) length. This enzyme therefore guarantees unabated cell division during carcinogenesis, characteristic cancer, this distinguishing factor has made TRTase spotlight target pharmaceutical research cancer therapy. The capacity nutraceuticals inhibit TRTase, impair TLMs, hinder complex formation offers window opportunity discovery new cancer-treatment targets. review attempts provide fundamental understanding TLM investigation, regulatory frameworks, diverse binding proteins TLM-TRTase structure. Moreover, study highlights address inhibition at molecular level, inhibitors catalytic subunits. thorough knowledge TRTase's physiological action will offer crucial information boosting effectiveness plausible chemotherapeutic drug designs.

Language: Английский

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Novel coumarins from green sweet bell pepper seeds: Their isolation, characterization, oxidative stress-mitigating, anticancer, anti-inflammatory, and antidiabetic properties

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138629 - 138629

Published: May 16, 2024

Language: Английский

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Natural linear coumarin-heterocyclic conjugates: A review of their roles in phytotherapy

Fitoterapia, Journal Year: 2024, Volume and Issue: 175, P. 105929 - 105929

Published: March 27, 2024

Language: Английский

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