Association between exposure to pyrethroids and chlorpyrifos at age 5 years and IQ at age 7 years among children from the Odense Child Cohort, a prospective birth cohort study

Environmental Research, Journal Year: 2025, Volume and Issue: 268, P. 120853 - 120853

Published: Jan. 14, 2025

Language: Английский

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Intranasal dantrolene nanoparticles inhibit lipopolysaccharide-induced depression and anxiety behavior in mice

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

This study investigates the therapeutic effectiveness of intranasal dantrolene nanoparticles pretreatment to inhibit lipopolysaccharide (LPS)-induced pathological inflammation and synapse destruction depressive anxiety behavior in mice. B6SJLF1/J adult mice were pretreated with (dantrolene: 5mg/kg), daily, Monday Friday, 5 days per week, for 4 weeks. Then, treated an intraperitoneal injection LPS (5mg/kg) one time. Behavioral tests depression performed 24 hours after a one-time injection. Biomarkers pyroptosis-related cytokines (IL-1β IL-18) blood brain measured using enzyme-linked immunosorbent assay (ELISA) immunoblotting, respectively. The changes primary proteins activation inflammatory pyroptosis (NLRP3: NLR family pyrin domain containing 3, Caspase-1, N-GSDMD: N terminal protein gasdermin D) (PSD-95 synpatin-1) brains immunoblotting. Intranasal robustly inhibited LPS-induced behavior. significantly elevation IL-1β IL-18 pyroptosis. ameliorated decrease PSD-95 synpatin-1 brains. Thus, have demonstrated neuroprotection against inflammation-mediated behaviors should be studied further as future effective drug treatment major disorder or psychiatric disorder.

Language: Английский

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Cholinergic interneurons in the nucleus accumbens are a site of cellular convergence for corticotropin‐releasing factor and estrogen regulation in male and female mice

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(5), P. 4937 - 4953

Published: July 30, 2024

Cholinergic interneurons (ChIs) act as master regulators of striatal output, finely tuning neurotransmission to control motivated behaviours. ChIs are a cellular target many peptide and hormonal neuromodulators, including corticotropin-releasing factor, opioids, insulin leptin, which can influence an animal's behaviour by signalling stress, pleasure, pain nutritional status. However, little is known about how sex hormones via estrogen receptors the function these other neuromodulators. Here, we performed in situ hybridisation on mouse tissue characterise effect choline acetyltransferase (Chat), receptor alpha (Esr1) factor type 1 (Crhr1) expression. Although did not detect differences ChAT protein levels dorsal striatum or nucleus accumbens, found that female mice have more Chat mRNA-expressing neurons than males both accumbens. At population level, observed sexually dimorphic distribution Esr1- Crhr1-expressing ventral was negatively correlated intact females, abolished ovariectomy present males. Only NAc find significant co-express Crhr1 Esr1 females lesser extent transcript were only during estrus phase indicating changes hormone modulate interaction between mRNA levels.

Language: Английский

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Effect of physical exercise on negative emotions in Chinese university students: The mediating effect of self-efficacy

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37194 - e37194

Published: Aug. 29, 2024

This study investigates the impact of physical activity on negative emotions among university students and examines mediating influence self-efficacy, aiming to furnish empirical insights a theoretical framework enhance optimize mental health this population comprehensively.

Language: Английский

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Breaking Barriers: Contemporary Challenges and Solutions in Male Mental Health

Published: Jan. 1, 2025

Language: Английский

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Inhibition of prefrontal glutamatergic neuron activity during the recovery period following chronic stress disrupts fear memory in male rats: potential role of the infralimbic cortex

Learning & Memory, Journal Year: 2025, Volume and Issue: 32(1), P. a053957 - a053957

Published: Jan. 1, 2025

Chronic stress typically leads to deficits in fear extinction. However, when a delay occurs from the end of chronic and start conditioning (a "recovery"), rats show improved context-cue discrimination, compared recently stressed or nonstressed rats. The infralimbic cortex (IL) is important for extinction undergoes neuronal remodeling after ends, which could drive discrimination. Here, glutamatergic IL neurons Sprague-Dawley male were targeted inhibition using inhibitory designer receptors exclusively activated by drugs (DREADDs) daily injections clozapine N-oxide (CNO) during 21-day recovery period stress. Histological verification confirmed DREADDs with some spread nearby medial prefrontal (PFC) regions. CNO administration was then discontinued before started behavioral testing thereafter so that assessments occurred without inhibition. Fear involved presenting three tone-foot shock pairings on 1 day, followed 2 days 15 tone-alone sessions. Daily repeated mainly did not disrupt learning all groups (controls, recovery, recovery). chronically given DREADD activation showed impaired spontaneous indicating failure form association. findings prior depends upon changes occur following

Language: Английский

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Causal Impacts of Psychiatric Disorders on Cognition and the Mediating Effect of Oxidative Stress: A Mendelian Randomization Study

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 162 - 162

Published: Jan. 29, 2025

Many psychiatric disorders are associated with major cognitive deficits. However, it is uncertain whether these deficits develop as a result of and what shared risk factors might mediate this relationship. Here, we utilized the Mendelian randomization (MR) analysis to investigate complex causal relationship between nine three phenotypes, while also examining potential mediating role oxidative stress biological underpinning. Schizophrenia (SZ), depressive disorder (MDD), attention deficit hyperactivity (ADHD) showed decreasing effect on performance, intelligence, education, bipolar (BPD) increased educational attainment. MR-Clust results exhibit genetic basis SZ other in relation function. Furthermore, when was considered factor, associations dimensions cognition, well MDD intelligence ADHD exhibited larger sizes than overall. Mediation MR supported effects cognition via traits, including carotene, vitamin E, bilirubin, uric acid. Finally, summary-based identified 29 genes both performance disorders. Our findings highlight importance considering understanding potentially treating impairments conditions.

Language: Английский

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Advance in the Mechanisms Underlying Prenatal Stress-induced Depressive-like Behavior in Offspring

Brain Behavior and Immunity Integrative, Journal Year: 2025, Volume and Issue: 9, P. 100108 - 100108

Published: Jan. 1, 2025

Language: Английский

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Endogenous 17β-estradiol regulates sexually dimorphic anxiety responses in zebrafish via the HPI axis and 5-HT/DA pathways

Frontiers in Marine Science, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 7, 2025

Anxiety is a multifaceted emotional response exhibited by animals when confronted with potential threats. Among most vertebrates, including mammals and fish, there pronounced sexual dimorphism in anxiety responses, females typically demonstrating higher levels than males. Concurrently, endogenous estrogen levels, specifically 17β-estradiol (E2), are significantly compared to This suggests positive regulatory role of E2 on anxiety, contributing sexually dimorphic fish. To elucidate the mediating male zebrafish ( Danio rerio ) were administered (E2-M), while treated letrozole (LET, an aromatase inhibitor that reduces synthesis, LET-F) for 60 days, plasma brain detected was evaluated novel tank diving test. Females (C-F) showed along elevated cortisol brain, reduced serotonin (5-HT) dopamine (DA) males (C-M). Treatment LET decreased female zebrafish, which corresponded lower increased 5-HT DA content. Additionally, expression genes associated E2, cortisol, 5- HT, pathways relevantly altered. Conversely, treatment (E2-M) content, corresponding changes gene expression. These findings strongly suggest positively regulates responses possibly modulating synthesis action 5-HT/DA brain.

Language: Английский

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Sex differences in the prevalence and clinical correlates of autistic features in patients with chronic schizophrenia: a large scale cross-sectional study

International Journal of Psychiatry in Clinical Practice, Journal Year: 2025, Volume and Issue: 29(1), P. 9 - 17

Published: Jan. 2, 2025

Sex differences have been suggested in both schizophrenia (SCZ) and autism spectrum disorder (ASD). This study aims to assess the prevalence clinical correlates of autistic features male female patients with chronic SCZ. A total 1690 SCZ (M/F: 1122/568) were recruited from ten psychiatric hospitals China. The Positive Negative Syndrome Scale Autism Severity Score Repeatable Battery for Assessment Neuropsychological Status (RBANS) utilised presence measure cognitive function, respectively. Female had a higher than patients. In patients, those exhibited illness duration RBANS scores, but lower years education. Whereas Binary logistic regression analysis revealed that education, duration, visuospatial/constructional abilities, language correlated language, delayed memory features. Our findings suggest sex exist

Language: Английский

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