Journal of Applied Physics,
Journal Year:
2025,
Volume and Issue:
137(5)
Published: Feb. 6, 2025
Superparamagnetic
nanoparticles
(SMNPs)
with
nonlinear
magnetic
behavior
under
alternating
fields
hold
great
potential
in
biomedical
applications,
including
hyperthermia,
biosensing,
separation,
particle
imaging,
etc.
Magnetic
hyperthermia
therapy,
based
on
the
relaxation
movement
of
SMNPs
subjected
to
an
field,
is
a
promising
modality
for
tumor
treatment.
Herein,
we
applied
stochastic
Langevin
equation
study
performance
by
taking
coupled
Brownian–Néel
rotations
into
account.
The
specific
absorption
rate
(SAR)
fluids
used
as
parameter
optimizing
amplitude
and
frequency
guiding
design
SMNPs.
Specifically,
accounting
dipole–dipole
interactions
between
SMNPs,
it
revealed
that
these
significantly
suppress
particles,
thereby
reducing
SAR.
Furthermore,
this
systematically
examines
effects
key
factors
such
concentration,
size,
anisotropy
constant
accurate
prediction
rotational
dynamics
oscillating
field
provides
valuable
theoretical
insights
technical
support
optimized
external
systems
precise
fabrication
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
372, P. 751 - 777
Published: July 4, 2024
Despite
significant
advances,
cancer
remains
a
leading
global
cause
of
death.
Current
therapies
often
fail
due
to
incomplete
tumor
removal
and
nonspecific
targeting,
spurring
interest
in
alternative
treatments.
Hyperthermia,
which
uses
elevated
temperatures
kill
cells
or
boost
their
sensitivity
radio/chemotherapy,
has
emerged
as
promising
alternative.
Recent
advancements
employ
nanoparticles
(NPs)
heat
mediators
for
selective
cell
destruction,
minimizing
damage
healthy
tissues.
This
approach,
known
NP
hyperthermia,
falls
into
two
categories:
photothermal
(PTT)
magnetothermal
(MTT).
PTT
utilizes
NPs
that
convert
light
heat,
while
MTT
magnetic
activated
by
alternating
fields
(AMF),
both
achieving
localized
damage.
These
methods
offer
advantages
like
precise
minimal
invasiveness,
reduced
systemic
toxicity.
However,
the
efficacy
hyperthermia
depends
on
many
factors,
particular,
properties,
microenvironment
(TME),
TME-NP
interactions.
Optimizing
this
treatment
requires
accurate
monitoring
strategies,
such
nanothermometry
biologically
relevant
screening
models
can
better
mimic
physiological
features
human
body.
review
explores
state-of-the-art
NP-mediated
discussing
available
nanomaterials,
strengths
weaknesses,
characterization
methods,
future
directions.
Our
particular
focus
lies
preclinical
techniques,
providing
an
updated
perspective
relevance
journey
towards
clinical
trials.
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: May 24, 2022
Abstract
Magnetic
hyperthermia
(MHT)
is
in
the
spotlight
of
nanomedical
research
for
treatment
cancer
employing
magnetic
iron
oxide
nanoparticles
and
their
intrinsic
capability
heat
dissipation
under
an
alternating
field
(AMF).
Herein
we
focus
on
synthesis
nanoflowers
(Nfs)
different
sizes
(15
35
nm)
coatings
(bare,
citrate,
Rhodamine
B)
while
comparing
physicochemical
magnetothermal
properties.
We
encapsulated
colloidally
stable
citrate
coated
Nfs,
both
sizes,
thermosensitive
liposomes
via
extrusion,
RhB
was
loaded
lipid
bilayer.
All
formulations
proved
hemocompatible
cytocompatible.
found
that
nm
at
lower
concentrations
than
15
served
better
as
nanoheaters
applications.
In
vitro
,
results
showed
promising
therapeutic
imaging
potential
magnetoliposomes
containing
Nfs
against
LLC
CULA
cell
lines
lung
adenocarcinoma.
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Aug. 19, 2022
In
the
present
work,
different
nanoparticles
spinel
ferrite
series
(MFe2O4,
Co0.5M0.5Fe2O4;
M
=
Co,
Mn,
Ni,
Mg,
Cu,
or
Zn)
have
been
obtained
via
sonochemical
approach.
Then,
sol-gel
method
was
employed
to
design
core-shell
magnetoelectric
nanocomposites
by
coating
these
with
BaTiO3
(BTO).
The
structure
and
morphology
of
prepared
samples
were
examined
X-ray
powder
diffraction
(XRD),
scanning
electron
microscope
(SEM)
coupled
energy
dispersive
spectroscopy
(EDX),
high-resolution
transmission
(HR-TEM),
zeta
potential.
XRD
analysis
showed
presence
BTO
phases
without
any
trace
a
secondary
phase.
Both
crystallized
in
cubic
structure.
SEM
micrographs
illustrated
an
agglomeration
spherical
grains
nonuniformly
diphase
orientation
degrees
agglomeration.
Moreover,
HR-TEM
revealed
interplanar
d-spacing
planes
that
are
good
agreement
those
phase
These
techniques
along
EDX
analyses
confirmed
successful
formation
desired
nanocomposites.
Zeta
potential
also
investigated.
biological
influence
CoMFe)
MNPs
(MFe2O4@BTO,
CoMFe@BTO)
MTT
DAPI
assays.
Post
48
h
treatments,
anticancer
activity
MENCs
investigated
on
human
colorectal
carcinoma
cells
(HCT-116)
against
cytocompatibility
normal
non-cancerous
(HEK-293).
It
established
possess
anti-colon
cancer
capability
while
exhibited
recovery
effect
due
protective
biocompatible
layer.
RBCs
hemolytic
NPs
has
ranged
from
non-
low-hemolytic
effect.
This
could
be
attributed
surface
charge
potential,
CoMnFe
possesses
stable
lowest
comparison
CoFe2O4
MnFe2O4
shell.
findings
open
up
wide
prospects
for
biomedical
applications
as
promising
drug
nanocarriers.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1130 - 1130
Published: March 22, 2023
In
this
article,
we
provide
an
overview
of
the
progress
scientists
working
to
improve
quality
life
cancer
patients.
Among
known
methods,
treatment
methods
focusing
on
synergistic
action
nanoparticles
and
nanocomposites
have
been
proposed
described.
The
application
composite
systems
will
allow
precise
delivery
therapeutic
agents
cells
without
systemic
toxicity.
nanosystems
described
could
be
used
as
a
high-efficiency
photothermal
therapy
system
by
exploiting
properties
individual
nanoparticle
components,
including
their
magnetic,
photothermal,
complex,
bioactive
properties.
By
combining
advantages
it
is
possible
obtain
product
that
would
effective
in
treatment.
use
nanomaterials
produce
both
drug
carriers
those
active
substances
with
direct
anti-cancer
effect
has
extensively
discussed.
section,
attention
paid
metallic
nanoparticles,
metal
oxides,
magnetic
others.
complex
compounds
biomedicine
also
A
group
showing
significant
potential
therapies
are
natural
compounds,
which
Cancers,
Journal Year:
2023,
Volume and Issue:
15(13), P. 3388 - 3388
Published: June 28, 2023
Glioblastoma
multiforme
(GB)
and
high-risk
neuroblastoma
(NB)
are
known
to
have
poor
therapeutic
outcomes.
As
for
most
cancers,
chemotherapy
radiotherapy
the
current
mainstay
treatments
GB
NB.
However,
limitations
of
systemic
toxicity,
drug
resistance,
targeted
delivery,
inability
access
blood-brain
barrier
(BBB),
make
these
less
satisfactory.
Other
treatment
options
been
investigated
in
many
studies
literature,
especially
nutraceutical
naturopathic
products,
which
also
reported
be
poorly
effective
against
cancer
types.
This
necessitates
development
strategies
with
potential
cross
BBB
specifically
target
cells.
Compounds
that
endopeptidase,
matrix
metalloproteinase
2
(MMP-2),
offer
insights
NB
since
MMP-2
is
over-expressed
cancers
plays
significant
roles
such
physiological
processes
as
angiogenesis,
metastasis,
cellular
invasion.
Chlorotoxin
(CTX)
a
promising
36-amino
acid
peptide
isolated
from
venom
deathstalker
scorpion,
Leiurus
quinquestriatus,
demonstrating
high
selectivity
binding
affinity
broad-spectrum
through
specific
molecular
targets,
including
MMP-2.
The
favorable
characteristics
nanoparticles
(NPs)
their
small
sizes,
large
surface
area
active
targeting,
permeability,
etc.
CTX-functionalized
NPs
(CTX-NPs)
diagnostic
applications
addressing
challenges
associated
cancers.
CTX-NPs
may
function
by
improving
diffusion
BBB,
enabling
increased
localization
chemotherapeutic
genotherapeutic
drugs
diseased
cells
specifically,
enhancing
imaging
modalities
magnetic
resonance
(MRI),
single-photon
emission
computed
tomography
(SPECT),
optical
techniques,
image-guided
surgery,
well
sensitization
radio-resistant
treatment.
review
discusses
related
CTX
its
functionalized
NP
formulations
targeting
systems
diagnostic,
therapeutic,
theranostic
purposes.
It
provides
into
mechanisms
crosses
bind
suggestions
application
novel
CTX-based
diagnosis
future.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 473 - 473
Published: March 28, 2024
Cancer
is
a
persistent
global
disease
and
threat
to
the
human
species,
with
numerous
cases
reported
every
year.
Over
recent
decades,
steady
but
slowly
increasing
mortality
rate
has
been
observed.
While
many
attempts
have
made
using
conventional
methods
alone
as
theragnostic
strategy,
they
yielded
very
little
success.
Most
of
shortcomings
such
can
be
attributed
high
demands
industrial
growth
ever-increasing
environmental
pollution.
This
requires
some
high-tech
biomedical
interventions
other
solutions.
Thus,
researchers
compelled
explore
alternative
methods.
brought
much
attention
nanotechnology
applications,
specifically
magnetic
nanomaterials,
sole
or
conjugated
The
exponential
nanomaterials
overlapping
applications
in
various
fields
due
their
potential
properties,
which
depend
on
type
synthesis
route
used.
Either
top-down
bottom-up
strategies
synthesize
types
NPs.
only
branches
out
one
method,
i.e.,
physical,
two
methods,
chemical
biological
syntheses.
review
highlights
techniques,
nanoparticle
properties
each
technique
produces,
use
field,
more
for
cancer.
Despite
evident
drawbacks,
success
achieved
furthering
complex
cancer
stages
locations
unmatched.
Journal of Biomaterials Applications,
Journal Year:
2024,
Volume and Issue:
39(1), P. 3 - 23
Published: April 12, 2024
Hyperthermia
therapy
refers
to
the
elevating
of
a
region
in
body
for
therapeutic
purposes.
Different
techniques
have
been
applied
hyperthermia
including
laser,
microwave,
radiofrequency,
ultrasonic,
and
magnetic
nanoparticles
latter
received
great
attention
recent
years.
Magnetic
cancer
aims
increase
temperature
tissue
by
locally
delivering
heat
from
cells
with
aid
an
external
alternating
field
kill
cancerous
or
prevent
their
further
growth.
This
review
introduces
nanoparticles.
It
includes
mechanism
operation
magnetism
behind
phenomenon.
synthesis
methods
surface
modification
enhance
biocompatibility,
water
solubility,
stability
physiological
environments
discussed.
Recent
research
on
versatile
types
ability
local
has
addressed.
ACS Applied Nano Materials,
Journal Year:
2022,
Volume and Issue:
5(8), P. 10118 - 10136
Published: Aug. 15, 2022
Magnetic
nanoparticles
(MNPs)
are
gaining
much
attention
due
to
their
applications
in
specialized
fields,
including
diagnosis,
bioimaging,
drug
delivery,
and
cell
therapy.
In
recent
years,
the
field
of
stem
regenerative
medicine
comprising
tissue
engineering
delivery
has
been
powered
by
nanoparticles.
Particularly,
mesenchymal
cells
(MSCs)
characterized
with
adequate
immunomodulatory
potential
coupled
an
excellent
ability
that
contributes
improved
therapy
various
diseases.
For
clinical
MSCs,
tracking
labeling
crucial
determine
homing
distribution.
Therefore,
high
MNPs
therapy,
this
review
comprehensively
uncovers
advancements
respective
field.
Also,
it
discusses
usage
surface-functionalized
materials
improving
physicochemical
properties
MNPs,
making
them
suitable
candidates
for
several
biomedical
applications.
Moreover,
we
have
discussed
these
within
applied
magnetic
electromagnetic
considered
multifunctional
agents
labeling,
stimulating,
tracking,
targeting
vitro
vivo.
Additionally,
discussion
comprises
progress
challenges
associated
used
as
effective
therapeutic,
diagnostic
treat
cancer,
cardiovascular,
neurodegenerative,
bone-related
disorders.
Finally,
also
widely
targeted
cancer
mechanical
force
killing
under
a
It
is
concluded
produced
low-frequency
vibrating
most
promising
safe
option
destruction
tumor
cells.
short,
summarized
role
nanomaterials
effective,
safe,
efficient
nanomaterial-cell-based
therapies.
