Combined Fluorescence-Guided Surgery with 5-Aminolevulinic Acid and Fluorescein in Glioblastoma: Technical Description and Report of 100 Cases

Cancers, Journal Year: 2024, Volume and Issue: 16(16), P. 2771 - 2771

Published: Aug. 6, 2024

Fluorescence-guided resection (FGR) of glioblastomas has been previously explored with the use 5-amivelulinic acid (5-ALA) and sodium fluoresceine (SF), allowing us to maximize extent (EoR). In this study, we highlight most relevant concerns regarding technique present methods results from experience our center.

Language: Английский

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Focused ultrasound for brain metastases: an update on global clinical trials

Journal of Neuro-Oncology, Journal Year: 2023, Volume and Issue: 165(1), P. 53 - 62

Published: Oct. 1, 2023

Language: Английский

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Curcuminoid Chalcones: Synthesis, Stability, and New Neuroprotective and Sonosensitising Activities

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1331 - 1331

Published: Sept. 21, 2023

The primary purpose of this work was to design and obtain a series curcuminoid chalcone-NSAID hybrid derivatives. ester-type compounds with ibuprofen (i), ketoprofen (ii), naproxen (iii) were obtained in two ways, using the Claisen-Schmidt reaction Steglich esterification reaction. designed molecules successfully synthesised, FT-IR, MS, NMR spectroscopy confirmed their structures. Moreover, cytotoxic effect sonodynamic therapy anti-inflammatory, antioxidant, anticholinergic properties some chalcones hybrids evaluated. chalcone derivatives showed promising neuroprotective activity as sonosensitisers for studied cell lines. Additionally, stability determined. RP-HPLC method used observe degradation tested compounds. Studies have shown that structural isomers (3ai, 3bi) are characterised by similar susceptibility factors, i.e., they extremely unstable alkaline environments, very acidic neutral practically stable oxidising photolabile solutions solid phase. These maintain adequate environment at pH 1.2 6.8, which may make them good candidates developing formulations oral administration.

Language: Английский

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Revolutionizing Brain Tumor Care: Emerging Technologies and Strategies

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1376 - 1376

Published: June 20, 2024

Glioblastoma multiforme (GBM) is one of the most aggressive forms brain tumor, characterized by a daunting prognosis with life expectancy hovering around 12–16 months. Despite century relentless research, only select few drugs have received approval for tumor treatment, largely due to formidable barrier posed blood–brain barrier. The current standard care involves multifaceted approach combining surgery, irradiation, and chemotherapy. However, recurrence often occurs within months despite these interventions. challenges drug delivery overcoming therapeutic resistance become focal points in treatment tumors are deemed essential recurrence. In recent years, promising wave advanced treatments has emerged, offering glimpse hope overcome limitations existing therapies. This review aims highlight cutting-edge technologies ongoing stages development, providing patients valuable insights guide their choices treatment.

Language: Английский

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An update on the role of focused ultrasound in neuro-oncology

Current Opinion in Neurology, Journal Year: 2024, Volume and Issue: 37(6), P. 682 - 692

Published: Oct. 4, 2024

Purpose of review Brain tumor treatment presents challenges for patients and clinicians, with prognosis many the most common brain tumors being poor. Focused ultrasound (FUS) can be deployed in several ways to circumvent these challenges, including need penetrate blood–brain barrier spare healthy tissue. This article reviews current FUS applications within neuro-oncology, emphasizing ongoing or recently completed clinical trials. Recent findings Most interest neuro-oncology remains focused on exploring BBB disruption enhance delivery standard-of-care therapeutics. More recently, application radiosensitization, liquid biopsy, sonodynamic therapy is garnering increased attention assist ablation, early detection, phenotypic diagnosis. Preclinical studies show encouraging data immunomodulatory effects FUS, but have yet tested clinically. Summary a burgeoning area research. Data from forthcoming large trials should help clarify its role care.

Language: Английский

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Combining ultrasound with sonosensitizers: The new frontline in glioma warfare

Neurosurgical Review, Journal Year: 2024, Volume and Issue: 47(1)

Published: Oct. 11, 2024

Language: Английский

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Targeted sonodynamic therapy induces tumor cell quasi-immunogenic ferroptosis and macrophage immunostimulatory autophagy in glioblastoma

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122913 - 122913

Published: Oct. 30, 2024

Language: Английский

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Focused Ultrasound for Brain Diseases: A Review of Current Applications and Future Perspectives

IRBM, Journal Year: 2023, Volume and Issue: 44(5), P. 100790 - 100790

Published: June 1, 2023

Language: Английский

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Targeted Sonodynamic Therapy Induces Tumor Cell Quasi-Immunogenic Ferroptosis and Macrophage Immunostimulatory Autophagy in Glioblastoma

Published: Jan. 1, 2024

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Language: Английский

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Elucidating viscoelastic effects on focused ultrasound thermal therapy with acoustic-solid-thermal coupling analysis

Acta Mechanica Sinica, Journal Year: 2024, Volume and Issue: 41(2)

Published: Aug. 22, 2024

Language: Английский

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