Advances in Bioscience and Biotechnology,
Journal Year:
2023,
Volume and Issue:
14(04), P. 190 - 209
Published: Jan. 1, 2023
The
Retinoblastoma
1
(RB1)
gene,
located
on
chromosome
13q14
and
encodes
the
tumor-suppressor
retinoblastoma
protein,
is
cause
of
Retinoblastoma.
mutational
inactivation
both
gene
alleles
brings
this
cancer.
(RB)
high-risk
histopathological
characteristics
indicate
metastasis
or
local
recurrence
with
rapid
progresses
following
RB1
inactivation.
There
growing
interest
in
regulatory
activities
unconnected
to
coding
region
genome,
exome,
addition
epigenetic
control
mechanisms.
altered
epigenome
significant,
though
by
no
means
only,
problem
etiology
After
all,
cancer
development
a
multistep
process
which
numerous
dissimilar
genetic,
epigenetic,
posttranscriptional
modifications
result
shared
phenotype.
This
study
emphasizes
most
recent
developments
change
epigenetics
related
tumor
biology.
Here,
we
highlight
novel
biomarkers
has
expressed
improve
patient
survival.
Ophthalmic Research,
Journal Year:
2023,
Volume and Issue:
unknown, P. 516 - 528
Published: Jan. 1, 2023
Circular
RNA
(circRNA)
is
a
newly
discovered
noncoding
RNA,
which
forms
closed
ring
with
more
than
200
bases
in
length.
CircRNA
formed
by
back
splicing
of
precursor
and
its
expression
abundance
body
fluid
up
to
10
times
that
homologous
linear
transcripts.
Recently,
novel
activities
for
circRNA
various
diseases
have
emerged,
ranging
from
cancer
therapy
neurodegenerative
diseases.
Here,
we
reviewed
the
literature
on
biogenesis
relationship
retinal
recent
years.
We
first
described
mechanism,
existing
form
main
function
circRNA.
Next,
also
pinpoint
has
great
value
diagnosis
treatment
represented
retinoblastoma,
degeneration,
diabetic
retinopathy.
By
this
review,
hope
explore
possibilities
clinical
treatment.
Environmental Toxicology,
Journal Year:
2022,
Volume and Issue:
37(6), P. 1483 - 1494
Published: March 28, 2022
Triple-negative
breast
cancer
(TNBC)
is
a
common
hypotype
of
cancer.
Circular
RNAs
(circRNAs)
are
burgeoning
serve
as
vital
controllers
in
numerous
tumors.
Nevertheless,
the
expression
and
regulatory
mode
circRNAs
TNBC
still
indistinct.
This
paper
aimed
to
reveal
function
molecular
mechanism
circular
RNA
dehydrodolichyl
diphosphate
synthase
(circDHDDS)
TNBC.The
contents
circDHDDS,
DHDDS
mRNA,
microRNA-362-3p
(miR-362-3p)
DEAD
(Asp-Glu-Ala-Asp)
box
polypeptide
5
(DDX5)
were
indicated
by
quantitative
real-time
polymerase
chain
reaction
(qRT-PCR)
western
blot.
The
colony
formation
assay
5-ethynyl-2'-deoxyuridine
(EdU)
executed
assess
cell
proliferation.
flow
cytometry
was
utilized
detect
apoptosis.
transwell
tube
applied
measure
migration,
invasion
angiogenesis.
targeted
relationships
miR-362-3p
circDHDDS
or
DDX5
forecasted
detected
dual-luciferase
reporter
assay.
vivo
test
implemented
confirm
effect
circDHDDS.The
increased,
level
decreased
TNBC.
CircDHDDS
deficiency
reserved
proliferation,
angiogenesis,
while
facilitated
apoptosis
cells.
Furthermore,
validated
exert
tumor
repressive
cells
suppressing
DDX5.
Moreover,
could
regulate
development
experimental
data
exposed
that
levels
presented
noteworthy
negative
correlation
with
DDX5,
exhibited
significant
positive
correlation.
In
mechanism,
bound
modulate
expression.
addition,
knock-down
also
attenuated
growth.CircDHDDS
expedited
swelling
via
adapting
miR-362-3p.
Asia-Pacific Journal of Ophthalmology,
Journal Year:
2024,
Volume and Issue:
13(3), P. 100072 - 100072
Published: May 1, 2024
Retinoblastoma
(RB),
originating
from
the
developing
retina,
is
an
aggressive
intraocular
malignant
neoplasm
in
childhood.
Biallelic
loss
of
RB1
conventionally
considered
a
prerequisite
for
initiating
RB
development
most
cases.
Additional
genetic
mutations
arising
genome
instability
following
are
proposed
to
be
required
promote
development.
Recent
advancements
high
throughput
sequencing
technologies
allow
deeper
and
more
comprehensive
understanding
etiology
that
additional
alterations
biallelic
rare,
yet
epigenetic
changes
driven
by
emerge
as
critical
contributor
promoting
tumorigenesis.
Multiple
regulators
have
been
found
dysregulated
contribute
development,
including
noncoding
RNAs,
DNA
methylations,
RNA
modifications,
chromatin
conformations,
histone
modifications.
A
full
roles
formation
crucial
facilitating
translation
these
findings
into
effective
treatment
strategies
RB.
In
this
review,
we
summarize
current
knowledge
concerning
defects
dysregulations
RB,
aiming
help
understand
their
links
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
12
Published: July 5, 2022
Retinoblastoma
(RB)
is
one
of
the
most
common
childhood
cancers
caused
by
RB
gene
mutations
(tumor
suppressor
in
various
patients).
A
better
understanding
molecular
pathways
and
development
new
diagnostic
approaches
may
lead
to
treatment
for
patients.
The
number
studies
on
ceRNA
axes
increasing,
emphasizing
significance
these
RB.
Circular
RNAs
(circRNAs)
play
a
vital
role
competing
endogenous
RNA
(ceRNA)
regulatory
sponging
microRNAs
regulating
expression.
Because
broadness
interaction
networks,
they
assist
investigating
targets
This
study
conducted
systematic
scoping
review
evaluate
verified
loops
RB,
focusing
axis
its
relationship
circRNAs.
was
carried
out
using
six-step
strategy
Prisma
guideline,
it
involved
systematically
searching
publications
seven
databases.
Out
363
records,
sixteen
articles
were
entirely
consistent
with
defined
inclusion
criteria
summarized
relevant
table.
majority
focused
circRNAs
circ_0000527,
circ_0000034,
circTET1,
approximately
two-fifths
single
circRNA.
Understanding
many
features
this
structure
help
elucidate
RB’s
unknown
causative
factors
provide
novel
potential
therapeutic
medical
fields.
Current Eye Research,
Journal Year:
2022,
Volume and Issue:
47(7), P. 1077 - 1086
Published: March 14, 2022
Increasing
evidence
reveals
that
circular
RNA
(circRNA)
dysregulation
is
involved
in
retinoblastoma
(RB)
pathogenesis.
To
further
realize
the
development
of
RB,
we
investigated
role
and
regulatory
mechanism
circ_0075804
RB.Real-time
quantitative
PCR
(RT-qPCR)
western
blot
were
employed
for
expression
analysis.
CCK-8
assay,
EdU
colony
formation
flow
cytometry
assay
transwell
performed
to
monitor
cell
phenotypes.
Xenograft
models
established
on
tumor
growth.
Tumor
growth
was
assessed
by
Ki67,
N-cadherin,
MMP2
MMP9
via
IHC
assay.
The
predicted
binding
sites
between
miR-1287-5p
or
LIM
SH3
protein
1
(LASP1)
validated
dual-luciferase
reporter
assay.Upregulation
LASP1,
downregulation
shown
RB
tissues
cells.
Circ_0075804
knockdown
repressed
growth,
invasion
survival,
hindered
vivo.
MiR-1287-5p
targeted
circ_0075804,
its
repression
largely
reversed
functional
effects
knockdown.
LASP1
a
target
miR-1287-5p.
inhibition
upregulation
proliferation,
survival
overexpression.
Moreover,
weakened
increasing
miR-1287-5p.Circ_0075804
promotes
targeting
miR-1287-5p,
thus
acting
as
contributor
carcinogenesis.HighlightsCirc_0075804
overexpressed
RB.Circ_0075804
inhibits
malignant
phenotypes
vivo.Circ_0075804
regulates
behaviors
miR-1287-5p.MiR-1287-5p
affects
LASP1.Circ_0075804
Advances in Bioscience and Biotechnology,
Journal Year:
2023,
Volume and Issue:
14(04), P. 190 - 209
Published: Jan. 1, 2023
The
Retinoblastoma
1
(RB1)
gene,
located
on
chromosome
13q14
and
encodes
the
tumor-suppressor
retinoblastoma
protein,
is
cause
of
Retinoblastoma.
mutational
inactivation
both
gene
alleles
brings
this
cancer.
(RB)
high-risk
histopathological
characteristics
indicate
metastasis
or
local
recurrence
with
rapid
progresses
following
RB1
inactivation.
There
growing
interest
in
regulatory
activities
unconnected
to
coding
region
genome,
exome,
addition
epigenetic
control
mechanisms.
altered
epigenome
significant,
though
by
no
means
only,
problem
etiology
After
all,
cancer
development
a
multistep
process
which
numerous
dissimilar
genetic,
epigenetic,
posttranscriptional
modifications
result
shared
phenotype.
This
study
emphasizes
most
recent
developments
change
epigenetics
related
tumor
biology.
Here,
we
highlight
novel
biomarkers
has
expressed
improve
patient
survival.
