Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156281 - 156281
Published: Nov. 24, 2024
Language: Английский
Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156281 - 156281
Published: Nov. 24, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2050 - 2050
Published: Feb. 26, 2025
Neuropathic pain, a debilitating condition arising from somatosensory system damage, significantly impacts quality of life, leading to anxiety, self-mutilation, and depression. Oxidative nitrosative stress, an imbalance between reactive oxygen nitrogen species (ROS/RNS) antioxidant defenses, plays crucial role in its pathophysiology. While are essential for physiological functions, excessive levels can cause cellular component neuronal dysfunction pain. This review highlights the complex interactions species, systems, cell signaling, neuropathic We discuss roles ROS/RNS detrimental effects oxidative stress. Furthermore, we explore potential manganese porphyrins, compounds with properties, as promising therapeutic agents mitigate stress alleviate pain by targeting key pathways involved Further research is needed fully understand their managing human non-human animals.
Language: Английский
Citations
2Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17
Published: Sept. 9, 2024
The transient receptor potential vanilloid 1 (TRPV1) channel plays a dual role in peripheral neuropathic pain (NeuP) by acting as “pain switch” through its sensitization and desensitization. Hyperalgesia, commonly resulting from tissue injury or inflammation, involves the of TRPV1 channels, which modulates sensory transmission primary afferent nociceptors to spinal dorsal horn neurons. In chemotherapy-induced neuropathy (CIPN), is implicated mechanisms due interaction with ion neurotransmitter signaling, oxidative stress. Sensitization root ganglion neurons contributes CIPN development, inhibition channels can reduce mechanical hypersensitivity. diabetic (DPN), involved modulation pathways including reactive oxygen species cytokine production. TRPV1’s TRPA1 further influences chronic onset progression. Therapeutically, capsaicin, agonist, induce analgesia desensitization, while antagonists siRNA targeting show promise preclinical studies. Cannabinoid provides another pathway for alleviating pain. This review summarizes recent research on association NeuP.
Language: Английский
Citations
6European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 980, P. 176845 - 176845
Published: July 26, 2024
Language: Английский
Citations
3Published: Jan. 1, 2024
Language: Английский
Citations
0Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156281 - 156281
Published: Nov. 24, 2024
Language: Английский
Citations
0