Nitroxidative Stress, Cell—Signaling Pathways, and Manganese Porphyrins: Therapeutic Potential in Neuropathic Pain

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2050 - 2050

Published: Feb. 26, 2025

Neuropathic pain, a debilitating condition arising from somatosensory system damage, significantly impacts quality of life, leading to anxiety, self-mutilation, and depression. Oxidative nitrosative stress, an imbalance between reactive oxygen nitrogen species (ROS/RNS) antioxidant defenses, plays crucial role in its pathophysiology. While are essential for physiological functions, excessive levels can cause cellular component neuronal dysfunction pain. This review highlights the complex interactions species, systems, cell signaling, neuropathic We discuss roles ROS/RNS detrimental effects oxidative stress. Furthermore, we explore potential manganese porphyrins, compounds with properties, as promising therapeutic agents mitigate stress alleviate pain by targeting key pathways involved Further research is needed fully understand their managing human non-human animals.

Language: Английский

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The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Sept. 9, 2024

The transient receptor potential vanilloid 1 (TRPV1) channel plays a dual role in peripheral neuropathic pain (NeuP) by acting as “pain switch” through its sensitization and desensitization. Hyperalgesia, commonly resulting from tissue injury or inflammation, involves the of TRPV1 channels, which modulates sensory transmission primary afferent nociceptors to spinal dorsal horn neurons. In chemotherapy-induced neuropathy (CIPN), is implicated mechanisms due interaction with ion neurotransmitter signaling, oxidative stress. Sensitization root ganglion neurons contributes CIPN development, inhibition channels can reduce mechanical hypersensitivity. diabetic (DPN), involved modulation pathways including reactive oxygen species cytokine production. TRPV1’s TRPA1 further influences chronic onset progression. Therapeutically, capsaicin, agonist, induce analgesia desensitization, while antagonists siRNA targeting show promise preclinical studies. Cannabinoid provides another pathway for alleviating pain. This review summarizes recent research on association NeuP.

Language: Английский

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PHARMACOLOGICAL AGENTS TARGETING TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNELS IN NEUROPATHIC PAIN: PRECLINICAL AND CLINICAL STATUS

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 980, P. 176845 - 176845

Published: July 26, 2024

Language: Английский

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Xibining Inhibition of the Pi3k-Akt Pathway Reduces M1 Macrophage Polarization to Ameliorate Koa Synovial Inflammation and Nociceptive Sensitization

Published: Jan. 1, 2024

Language: Английский

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Xibining inhibition of the PI3K-AKT pathway reduces M1 macrophage polarization to ameliorate KOA synovial inflammation and nociceptive sensitization

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156281 - 156281

Published: Nov. 24, 2024

Language: Английский

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