Efficacy and Safety of Phase 1 of Very Low Energy Ketogenic Therapy (VLEKT) in Subjects with Obesity and Mild Renal Impairment

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 721 - 721

Published: Feb. 18, 2025

Background: Obesity impairs renal function through direct mechanisms, such as proinflammatory adipocytokine production, and indirect including obesity-related comorbidities. Despite the increasing prevalence of obesity chronic kidney disease (CKD), clinical guidelines for their combined management remain lacking. Very Low Energy Ketogenic Therapy (VLEKT) has demonstrated efficacy in weight loss, but evidence on its safety individuals with mild impairment is limited. This study aimed to assess Phase 1 VLEKT impairment. Methods: cross-sectional included 73 overweight or (mean age 53.7 ± 8.8 years; BMI 35.3 4.2 kg/m2) an estimated glomerular filtration rate (eGFR) at least 60 mL/min/1.73 m2 (evaluated using CKD-EPI equation). Anthropometric (weight, BMI, waist circumference) biochemical parameters (fasting plasma glucose, insulin, cholesterol profile, triglycerides, AST, ALT, urea) were collected baseline after 45 (±2) days VLEKT. Results: At baseline, 54.8% participants had eGFR <90 m2, while 45.2% ≥ 90 no significant differences sex distribution. After VLEKT, both groups showed reductions (p < 0.001), circumference fasting glucose ≤ 0.004), insulin HOMA-IR total LDL LDL/HDL ratio 0.002), triglycerides 0.009), AST 0.034), ALT 0.009). Notably, significantly increased changes observed those m2. Conclusions: could effectively promote loss metabolic improvements without compromising function, even Further research warranted confirm outcomes across all protocol phases.

Language: Английский

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Scientific evidence underlying contraindications to the ketogenic diet: An update

Obesity Reviews, Journal Year: 2020, Volume and Issue: 21(10)

Published: July 10, 2020

Summary First identified as a feasible treatment for intractable epilepsy, the ketogenic diet (KD) has recently gained popularity thanks to growing evidence on applications such weight loss, most importantly, but also NAFLD, cancer, neurologic conditions and chronic pain. As with any treatment, whether pharmacologic or not, KD might not be an appropriate intervention every individual, number of contraindications have been proposed, now deeply rooted into clinical practice, excluding de facto many patients that could benefit from its use. However, these concerns were expressed due absence studies conducted fragile populations, assessment lately emerged relative safety is currently lacking much needed. We herein provide critical revision literature behind each alert, in order guide through options case subjects indication borderline safe situation. Based available evidence, possible use this therapeutic should assessed patient‐to‐patient basis by adequately skilled medical doctors, keeping mind current recommendations, reading them knowledge state art.

Language: Английский

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The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool?

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 157 - 157

Published: Jan. 22, 2021

Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system may lead overproduction pro-inflammatory cytokines. Fatty acids as macronutrients key players for immunomodulation, with n-3 polyunsaturated fatty having most beneficial effect, while polyphenols carotenoids seem be promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease multifactorial etiology. Obesity major risk factor psoriasis, which leads worse clinical outcomes. Weight loss interventions and, generally, regimens such gluten-free Mediterranean diet or supplement use potentially improve psoriasis’ natural course response therapy. However, data about more sophisticated nutritional patterns, ketogenic, very low-carb specific macro- micro-nutrient substitution, scarce. This review aims present effect strictly structured nutrients, known affect glucose/lipid metabolism insulin responses, on chronic immunity, discuss utility possible therapeutic tools psoriasis psoriatic arthritis.

Language: Английский

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Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study

Journal of Proteome Research, Journal Year: 2020, Volume and Issue: 20(3), P. 1509 - 1521

Published: Nov. 9, 2020

Psoriasis is an inflammatory disease of the epidermis based on immunological mechanism involving Langerhans cells and T lymphocytes that produce pro-inflammatory cytokines. Genetic factors, environmental improper nutrition are considered triggers disease. Numerous studies have reported in a high number patients, psoriasis associated with obesity. Excess adipose tissue, typical obesity, causes systemic status coming from active tissue; therefore, weight reduction strategy to fight this state. This study aimed evaluate how nutritional regimen ketogenic diet influenced clinical parameters, metabolic profile, state patients. To end, 30 patients were subjected monitored for 4 weeks by evaluating data, biochemical NMR metabolomic IL-2, IL-1β, TNF-α, IFN-γ, IL-4 concentrations before after regimen. Our data show low-calorie can be successful therapeutic option gain improvement psoriasis-related dysmetabolism, significant correction full status.

Language: Английский

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Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(9), P. 3228 - 3228

Published: May 2, 2020

Adipose tissue is a multifunctional organ involved in many physiological and metabolic processes through the production of adipokines and, particular, adiponectin. Caloric restriction one most important strategies against obesity today. The very low-calorie ketogenic diet (VLCKD) represents type caloric with or extremely low daily food energy consumption. This study aimed to investigate effects VLCKD on anthropometric biochemical parameters such as adiponectin levels, well analyzing oligomeric profiles cytokine serum levels obese subjects before after VLCKD. Twenty were enrolled. At baseline eight weeks intervention, parameters, recorded. Our findings showed significant change these We found negative correlation between lipid profile, visceral adipose (VAT), C-reactive protein (CRP), pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), which confirmed involvement inflammatory diseases. demonstrated beneficial short-term not only treatment but also establishment obesity-correlated

Language: Английский

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Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes

Nutrients, Journal Year: 2021, Volume and Issue: 13(3), P. 758 - 758

Published: Feb. 26, 2021

Obesity-related type 2 diabetes represents one of the most difficult challenges for healthcare system. This retrospective study aims to determine efficacy, safety and durability a very-low-calorie ketogenic diet (VLCKD), compared standard low-calorie (LCD) on weight-loss, glycemic management, eating behavior quality life in patients with (T2DM) obesity. Thirty obesity T2DM, aged between 35 75 years, who met inclusion criteria accepted adhere VLCKD or LCD nutritional program, were consecutively selected from our electronic database. Fifteen followed structured protocol, fifteen classical LCD. At beginning all asked stop any antidiabetic medications, exception metformin. Data collected at baseline after 3 (T1) 12 (T2) months. T1 T2, BMI was significantly reduced group (p < 0.001), whereas it remained substantially unchanged group. HbA1c = 0.002), slight, although not significant, decrease observed Quality scores improved group, no significant changes reported both T2. end study, 26.6% had stopped 73.3% taking only metformin, 46.6% increase medications. The confirms valuable therapeutic effect long-term management T2DM its potential contribution remission disease.

Language: Английский

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Effects of Calorie Restriction on Health Span and Insulin Resistance: Classic Calorie Restriction Diet vs. Ketosis-Inducing Diet

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1302 - 1302

Published: April 15, 2021

As the incidence of Chronic Non-Communicable Diseases (CNCDs) increases, preventive approaches become more crucial. In this review, calorie restriction (CR) effects on human beings were evaluated, comparing benefits and risks different CR diets: classic vs. ketosis-inducing diets, including intermittent fasting (IF), ketogenic diet (CKD), mimicking (FMD), very-low-calorie Diet (VLCKD) Spanish Mediterranean (SKMD). Special emphasis insulin resistance (IR) was placed, as it mediates metabolic syndrome (MS), a known risk factor for CNCD, is predictive MS diagnosis. most robust intervention to increase lifespan health span, with high evidence biochemical mechanisms. improves cardiometabolic parameters, boosts exercise sensitivity response, there may be implementing moderate healthy young middle-aged individuals. However, insufficient support long-term CR. CKD effective weight management, have additional such prevention muscle loss appetite control. SKMD has extreme significance all parameters studied. Studies show inconsistent IF compared More studies are required study reinforce evidence, identify risks, seek safe nutritional approaches.

Language: Английский

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Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases

Aging and Disease, Journal Year: 2022, Volume and Issue: 13(4), P. 1146 - 1146

Published: Jan. 1, 2022

The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As mimicking fasting, it triggers the production of ketone bodies (KBs) brings body into state ketosis. Recent accumulating studies on humans animal models have shown that KD beneficial to neurodegenerative diseases through modulating central peripheral metabolism, mitochondrial function, inflammation, oxidative stress, autophagy, gut microbiome. Complicated interplay microbiome, other mechanisms can regulate neuroinflammation in by activating multiple molecular cellular pathways. In this review, we detail physiological basis KD, its functions regulating neuroinflammation, protective role normal brain aging diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS), Huntington’s (HD). We aimed elucidate underlying neuroinflammatory therapies provide novel insights their application for prevention treatment.

Language: Английский

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Estrogens and the regulation of glucose metabolism

World Journal of Diabetes, Journal Year: 2021, Volume and Issue: 12(10), P. 1622 - 1654

Published: Oct. 13, 2021

The main estrogens: estradiol, estrone, and their acyl-esters have been studied essentially related to classical estrogenic pharmacologic functions.However, effect in the body is probably sustained control of core energy metabolism.Estrogen nuclear membrane receptors show an extraordinary flexibility modulation metabolic responses, largely explain gender age differences metabolism: part these mechanisms already sufficiently known justify both.With regard energy, estrogen molecular species act through four key functions: (1) Facilitation insulin secretion glucose availability; (2) Modulation partition, favoring use lipid as substrate when more available than carbohydrates; (3) Functional protection antioxidant mechanisms; (4) Central effects (largely neural modulation) on whole management.Analyzing different actions estradiol acyl esters, a tentative classification based structure/effects has postulated.Either separately or group, estrogens provide comprehensive explanation that not all quite diverse are solely specific molecules.As they constitute powerful synergic action complex.In consequence, may be considered wardens homeostasis.

Language: Английский

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Ketogenic diets, physical activity and body composition: a review

British Journal Of Nutrition, Journal Year: 2021, Volume and Issue: 127(12), P. 1898 - 1920

Published: July 12, 2021

Abstract Obesity remains a serious relevant public health concern throughout the world despite related countermeasures being well understood (i.e. mainly physical activity and an adjusted diet). Among different nutritional approaches, there is growing interest in ketogenic diets (KD) to manipulate body mass (BM) enhance fat loss. KD reduce daily amount of carbohydrate intake drastically. This results increased fatty acid utilisation, leading increase blood ketone bodies (acetoacetate, 3- β -hydroxybutyrate acetone) therefore metabolic ketosis. For many years, intervention studies have focused on reducing dietary with little or conflicting positive over long term. Moreover, current guidelines for athletes propose carbohydrate-based augment muscular adaptations. review discusses physiological basis their effects BM reduction composition improvements sedentary individuals combined types exercise (resistance training endurance training) obesity athletes. Ultimately, we discuss strengths weaknesses these interventions together precautionary measures that should be observed both athletic populations. A literature search from 1921 April 2021 using Medline, Google Scholar, PubMed, Web Science, Scopus Sportdiscus Databases was used identify studies. In summary, based evidence, are efficient method However, impacts because appetite suppressive KD, which can decrease energy intake. Therefore, do not any superior benefits non-KD loss populations isoenergetic situation. obesity, it seems fat-free (FFM) changes appear as great, if greater, than decreases following low-fat diet. terms lean mass, cause FFM resistance-trained individuals. contrast, FFM-preserving more endurance-trained compared

Language: Английский

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