The Association Between COVID-19 and Thyroxine Levels: A Meta-Analysis DOI Creative Commons
Yiru Chen, Xiuneng Li, Yu Dai

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 4, 2022

Objectives Recently, a number of reports have described the potential relationship between COVID-19 and thyroid hormones, but results were conflicting. We performed meta-analysis to evaluate effect severity on thyroid-related hormones outcome in order try confirm association serum levels free triiodothyronine (FT3), thyroxine (FT4) stimulating hormone (TSH) or mortality coronavirus-19 patients. Methods The methodology was already registered International Prospective Register Systematic Reviews (PROSPERO) database, protocol is CRD42021269246. searches carried out Cochrane Library, Embase, PubMed Web Science databases November 15, 2021. set up literature search strategy based following keywords: [(T3 OR FT3 triiodothyronine) (T4 FT4 thyroxine) (TSH thyrotropin)] (COVID-19 SARS-CoV-2), without time restrictions. Results Twenty studies satisfied inclusion/exclusion criteria included meta-analysis. A total 3609 patients enrolled study. From analysis studies, incidence abnormalities higher with severe COVID-19, TSH lower than those nonsevere COVID-19. However, difference not significant. Similar characteristics shown survivors nonsurvivors. In addition, outcomes showed that abnormal had greater mortality. Conclusions Low levels, low may increase during admission. On other hand, level probability decreases FT3, FT4, levels.

Language: Английский

New aspects in the pathogenesis and management of subacute thyroiditis DOI Creative Commons
Magdalena Stasiak, Andrzej Lewiński

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2021, Volume and Issue: 22(4), P. 1027 - 1039

Published: May 5, 2021

Abstract Subacute thyroiditis (SAT) is a thyroid inflammatory disease, whose pathogenesis and determinants of the clinical course were unclear for many decades. The last few years have brought clinically significant new data on epidemiology, management SAT. Several human leukocyte antigen (HLA) alleles demonstrated not only to increase risk SAT, but also correlate with SAT determine recurrence. world-wide epidemic coronavirus disease 19 (COVID-19) has provided observations that severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) can be potent SAT-triggering factor, in patients affected by COVID-19 different from typical one. Additionally, trends are emerging. In years, painless more often described, constituting special challenge hospitalized due COVID-19. Despite an excellent availability diagnostic methods, several difficulties differential diagnosis currently encountered proper treatment frequently delayed. False positive diagnoses malignancies poor prognosis constitute life-threatening problem. Taking into account all aspects its course, – modified criteria been proposed.

Language: Английский

Citations

125
Post COVID-19 sequelae: A prospective observational study from Northern India DOI Open Access
Shivdas Naik, Soumendra Nath Haldar, Manish Soneja

et al.

Drug Discoveries & Therapeutics, Journal Year: 2021, Volume and Issue: 15(5), P. 254 - 260

Published: Oct. 29, 2021

Post COVID-19 sequelae are a constellation of symptoms often reported after recovering from COVID-19. There is need to better understand the clinical spectrum and long-term course this entity. The aim study describe features risk factors post in North Indian population. This prospective observational was conducted at tertiary healthcare centre Northern India between October 2020 February 2021. Patients aged >18 years with laboratory-confirmed were recruited least two weeks diagnosis, details captured. A total 1234 patients followed up for median duration 91 days (IQR: 45-181 days). Among them, 495 (40.1%) had persistent post-discharge or recovery. In 223 (18.1%) patients, resolved within four weeks; 150 (12.1%) till 12 weeks, 122 (9.9%) beyond diagnosis/symptom-onset Most common included myalgia (10.9%), fatigue (5.5%), shortness breath (6.1%), cough (2.1%), insomnia (1.4%), mood disturbances (0.48%) anxiety (0.6%). who hospitalized more likely report as feature long COVID. Hypothyroidism (OR: 4.13, 95% CI: 2.2-7.6, p-value < 0.001) hypoxia (SpO2 ≤ 93%) 1.7, 1.1-2.4, 0.012) identified COVID sequelae. conclusion, (22%), 9.9% syndrome. Myalgias, dyspnoea symptoms. hypothyroidism during acute illness higher

Language: Английский

Citations

114
Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis DOI

Wilmar M. Wiersinga,

Kris Poppe, Grigoris Effraimidis

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(4), P. 282 - 298

Published: Feb. 24, 2023

Language: Английский

Citations

114
SARS-CoV-2 triggering autoimmune diseases DOI Open Access
Leila Mobasheri, Mohammad Hossein Nasirpour, Elham Masoumi

et al.

Cytokine, Journal Year: 2022, Volume and Issue: 154, P. 155873 - 155873

Published: April 5, 2022

Language: Английский

Citations

96
Long-Term Effects of COVID-19 DOI Open Access
Shreeya Joshee,

Nikhil Vatti,

Christopher Chang

et al.

Mayo Clinic Proceedings, Journal Year: 2022, Volume and Issue: 97(3), P. 579 - 599

Published: Jan. 12, 2022

Language: Английский

Citations

92
Thyroid dysfunction following vaccination with COVID-19 vaccines: a basic review of the preliminary evidence DOI Open Access
Abdollah Jafarzadeh, Maryam Nemati, Sara Jafarzadeh

et al.

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 45(10), P. 1835 - 1863

Published: March 26, 2022

Language: Английский

Citations

71
SARS‐CoV‐2 infection and multi-organ system damage: a review DOI Open Access
Ali A. Rabaan, Samira Smajlović, Hüseyin Tombuloğlu

et al.

Bosnian Journal of Basic Medical Sciences, Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 16, 2022

The SARS-CoV-2 infection causes COVID-19, which has affected approximately six hundred million people globally as of August 2022. Organs and cells harboring angiotensin-converting enzyme 2 (ACE2) surface receptors are the primary targets virus. However, once it enters body through respiratory system, virus can spread hematogenously to infect other organs. Therefore, COVID-19 affects many organs, causing severe long-term complications, even after disease ended, thus worsening quality life. Although is known that system most by infection, organs/systems in short long term. Since simultaneously redesigning diagnostic therapy policies fit damaged organs strongly recommended. Even though pathophysiology problems unknown, frequency cases rises with age existence preexisting symptoms. This study aims update our knowledge multi-organ dysfunction interaction based on clinical theoretical evidence. For this purpose, comprehensively elucidates recent studies effects multiple systems, including respiratory, cardiovascular, gastrointestinal, renal, nervous, endocrine, reproductive, immune, parts integumentary system. Understanding range atypical symptoms could improve surveillance, limit transmission, avoid additional multi-organ-system problems.

Language: Английский

Citations

71
Covid-19 a triggering factor of autoimmune and multi-inflammatory diseases DOI Creative Commons

Emina Karahmet Sher,

Adnan Ćosović,

Amina Džidić-Krivić

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 319, P. 121531 - 121531

Published: Feb. 27, 2023

SARS-CoV-2 virus has attracted a lot of attention globally due to the autoimmune and inflammatory processes that were observed during development Covid-19 disease. Excessive activation immune response triggering autoantibodies synthesis as well an excessive cytokines onset cytokine storm vital role in disease outcome occurring complications. This scenario is reminiscent infiltration lymphocytes monocytes specific organs increased production chemoattractants noted other diseases. The main goal this study investigate complex occur find similarities with diseases such multiple sclerosis (MS), acute respiratory distress syndrome (ARDS), rheumatoid arthritis (RA) Kawasaki advance existing diagnostic therapeutic protocols. therapy Interferon-gamma (IFN-γ) use S1P receptor modulators showed promising results. However, there are many unknowns about these mechanisms possible novel therapies. Therefore, inflammation autoimmunity triggered by should be further investigated improve procedures protocols for Covid-19.

Language: Английский

Citations

46
Thyroid dysfunction in COVID-19 DOI
David Tak Wai Lui, Chi‐Ho Lee,

Yu Cho Woo

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(6), P. 336 - 348

Published: Feb. 12, 2024

Language: Английский

Citations

20
Thyroid and COVID-19: a review on pathophysiological, clinical and organizational aspects DOI Creative Commons
Giuseppe Lisco, Anna De Tullio, Emilio Jirillo

et al.

Journal of Endocrinological Investigation, Journal Year: 2021, Volume and Issue: 44(9), P. 1801 - 1814

Published: March 25, 2021

Abstract Background Thyroid dysfunction has been observed in patients with COVID-19, and endocrinologists are requested to understand this clinical issue. Pandemic-related restrictions reorganization of healthcare services may affect thyroid disease management. Objective methods To analyze discuss the relationship between COVID-19 diseases from several perspectives. PubMed/MEDLINE, Google Scholar, Scopus, ClinicalTrial.gov were searched for purpose by using free text words medical subject headings as follows: “sars cov 2”, “covid 19”, “subacute thyroiditis”, “atypical “chronic “hashimoto’s “graves’ disease”, “thyroid nodule”, “differentiated cancer”, “medullary “methimazole”, “levothyroxine”, “multikinase inhibitor”, “remdesivir”, “tocilizumab”. Data collected, analyzed, discussed answer following questions: “What evidence suggests that induce detrimental consequences on function?"; "Could previous or concomitant deteriorate prognosis once infection occurred?”; “Could management influence course COVID-19?”; “Does interfere function?”; “Are there defined strategies better manage endocrine despite restrictive measures in-hospital ambulatory activities reorganizations?”. Results SARS-CoV-2 is usually reversible, including subclinical atypical thyroiditis. Patients baseline not at higher risk contracting transmitting SARS-CoV-2, does foster a worse progression COVID-19. However, it unclear whether low levels triiodothyronine, seriously ill worsen disease's and, consequently, if triiodothyronine supplementation could be tool reducing burden. Glucocorticoids heparin hormone secretion measurement, respectively, leading possible misdiagnosis severe cases High-risk nodules require fine-needle aspiration without relevant delay, whereas other non-urgent diagnostic procedures therapeutic interventions should postponed. Discussion Currently, we know lead short-term reversible dysfunction, but seem Adequate remains essential during pandemic, compromised because service restrictions. Endocrine care centers continuously recognize classify priority in-person visits procedures. Telemedicine useful managing requiring visits.

Language: Английский

Citations

100