A Novel Metabolic Risk Classification System Incorporating Body Fat, Waist Circumference, and Muscle Strength DOI Creative Commons

Carlos Raúl Robledo-Millán,

María Regina Diaz-Domínguez,

Ari Evelyn Castañeda-Ramírez

et al.

Journal of Functional Morphology and Kinesiology, Journal Year: 2025, Volume and Issue: 10(1), P. 72 - 72

Published: Feb. 22, 2025

Background: As metabolic diseases continue to rise globally, there is a growing need improve risk assessment strategies beyond traditional measures such as BMI and waist circumference, which may fail identify individuals at risk. This study develops validates novel classification system that incorporates body fat percentage (%BF), circumference (WC), grip strength (GS) in Mexican adults. It aims stratification evaluate the association with syndrome. Methods: cross-sectional involved 300 young adults (18–22 years) from university Mexico City, utilizing composition (%BF) anthropometric (WC, GS) categorize them into four groups: protective, low risk, increased high A retrospective cohort of 166 (18–65 complete clinical records was used for validation. Results: The inclusion GS significantly shifted distribution adult cohort, reducing “no risk” category (15.5% males, 11.6% females) expanding higher-risk categories (70.2% 69% females). Metabolic parameters fasting glucose, triglycerides, HDL cholesterol, blood pressure worsened progressively across (p < 0.001). high-risk group exhibited markedly odds ratio syndrome 28.23 (10.83–73.6, p 0.001), no cases protective low-risk groups. Conclusions: Integrating %BF WC substantially enhances stratification, identifies at-risk not previously detected, confirms group. validated provides robust tool early detection targeted interventions, improving public health outcomes health.

Language: Английский

EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD) DOI Creative Commons
Frank Tacke, Paul Horn, Vincent Wai–Sun Wong

et al.

Journal of Hepatology, Journal Year: 2024, Volume and Issue: 81(3), P. 492 - 542

Published: June 7, 2024

Language: Английский

Citations

373
EASL-EASD-EASO Clinical Practice Guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) DOI Creative Commons
Frank Tacke, Paul Horn, Vincent Wai–Sun Wong

et al.

Obesity Facts, Journal Year: 2024, Volume and Issue: 17(4), P. 374 - 444

Published: Jan. 1, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty (NAFLD), is defined as (SLD) in the presence of one or more cardiometabolic risk factor(s) and absence harmful alcohol intake. The spectrum MASLD includes steatosis, metabolic steatohepatitis (MASH, NASH), fibrosis, cirrhosis MASH-related hepatocellular carcinoma (HCC). This joint EASL-EASD-EASO guideline provides an update on definitions, prevention, screening, diagnosis treatment for MASLD. Case-finding strategies with using non-invasive tests, should be applied individuals factors, abnormal enzymes, and/or radiological signs hepatic particularly type 2 diabetes (T2D) obesity additional factor(s). A stepwise approach blood-based scores (such FIB-4) and, sequentially, imaging techniques transient elastography) suitable to rule-out/in advanced which predictive liver-related outcomes. In adults MASLD, lifestyle modification - including weight loss, dietary changes, physical exercise discouraging consumption well optimal management comorbidities use incretin-based therapies (e.g. semaglutide, tirzepatide) T2D obesity, if indicated advised. Bariatric surgery also option obesity. If locally approved dependent label, non-cirrhotic MASH significant fibrosis (stage ≥2) considered a MASH-targeted resmetirom, demonstrated histological effectiveness acceptable safety tolerability profile. No pharmacotherapy can currently recommended cirrhotic stage. Management adaptations drugs, nutritional counselling, surveillance portal hypertension HCC, transplantation decompensated cirrhosis.

Language: Английский

Citations

67
Advances in Understanding the Interplay between Dietary Practices, Body Composition, and Sports Performance in Athletes DOI Open Access
Alexandra Martín-Rodríguez, Pedro Belinchón-deMiguel, Alejandro Rubio-Zarapuz

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 571 - 571

Published: Feb. 19, 2024

The dietary practices of athletes play a crucial role in shaping their body composition, influencing sports performance, training adaptations, and overall health. However, despite the widely acknowledged significance intake athletic success, there exists gap our understanding intricate relationships between nutrition, performance. Furthermore, emerging evidence suggests that many fail to adopt optimal nutritional practices, which can impede potential achievements. In response, this Special Issue seeks gather research papers delve into athletes’ impacts on composition Additionally, studies focusing interventions aimed at optimizing habits are encouraged. This paper outlines key aspects points will be developed ensuing articles Issue.

Language: Английский

Citations

30
The Triglyceride/HDL Ratio as a Surrogate Biomarker for Insulin Resistance DOI Creative Commons

Petru Baneu,

Cristina Văcărescu,

Simona Drăgan

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1493 - 1493

Published: July 5, 2024

Given the widespread occurrence of insulin resistance, a key factor in metabolic syndrome and distinct condition altogether, there is clear need for effective, surrogate markers. The triglyceride-to-high-density lipoprotein (TG/HDL) ratio stands out as viable option, indicative changes lipid metabolism associated with offering cost-effective straightforward alternative to traditional, more complex biomarkers. This review, line PRISMA guidelines, assesses TG/HDL ratio’s potential an indirect indicator resistance. Analysing 32 studies over 20 years, involving 49,782 participants diverse ethnic backgrounds, including adults children, this review primarily uses cross-sectional analysis Homeostatic Model Assessment Insulin Resistance (HOMA-IR) gauge It reveals varied predictive power across ethnicities sexes, specific thresholds providing greater accuracy Caucasians, Asians, Hispanics African Americans men women. Valid different weights ages, it suggests average cutoffs 2.53 women 2.8 men. supports simple, accessible marker though advises further research on tailored reflecting gender differences.

Language: Английский

Citations

20
A longitudinal study of factors associated with cognitive frailty in middle-aged and elderly population based on the health ecology model DOI Creative Commons

Dingchun Hou,

Yumei Sun, Zhike Liu

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 352, P. 410 - 418

Published: Feb. 15, 2024

Cognitive frailty (CF) is an important geriatric syndrome and reversible. It crucial to develop preventive interventions for CF. We aimed explore the associations between CF its associated factors in Chinese aged 45 years above.

Language: Английский

Citations

11
Bioelectrical Impedance Versus Air-Displacement Plethysmography for Body Fat Measurements in Subjects with Abdominal Obesity: A Comparative Study DOI Creative Commons
Iuliana Creţescu, Raluca Horhat, Valeria Mocanu

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 2056 - 2056

Published: Feb. 16, 2025

Obesity is a disorder with an increasing prevalence, associated cardiovascular and metabolic pathologies. The amount the distribution pattern of adipose tissue must be considered when managing this disease. Abdominal obesity carries higher risk developing obesity-related comorbidities. Body composition methods allow objective diagnosis follow-up in obese patients. Although bioelectrical impedance (BIA) practical, affordable, widespread technique to assess body fat percentage (%BF), its accuracy has often been questioned. Therefore, present study aimed determine BIA’s subjects abdominal compared air-displacement plethysmography (AP) as reference method. Measurements both techniques were performed on 80 (41 men 39 women) large range mass indexes (BMIs). obesity, diagnosed waist-to-height ratio (WHtR) above 0.5, was 28 them. Agreement between analyzed using t-tests, correlation, Bland–Altman plots. Compared AP, BIA underestimated %BF by 3.07 ± 5.81% (CCC = 0.82) entire group. agreement comparable without central (2.97 6.21% 3.26 5.1%, respectively). changes shape geometry due different patterns only marginally affected determinations.

Language: Английский

Citations

2
Phenotyping the obesities: reality or utopia? DOI Creative Commons
Piero Portincasa, Gema Frühbeck

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 24(5), P. 767 - 773

Published: Aug. 4, 2023

In this thematic issue on phenotyping the obesities, prominent international experts offer an insightful and comprehensive collection of articles covering current knowledge in field. order to actually capture all polyhedral determinants diverse types obesity, granularity phenotypic information acquired must be expanded context a personalized approach. Whilst use precision medicine has been successfully implemented areas like cancer other diseases, health care providers are more reluctant embrace detailed guide diagnosis, treatment prevention obesity. Given its multiple complex layers, necessarily needs go beyond multi-omics approach incorporate spheres that conform reality people living with Potential barriers, difficulties, roadblocks opportunities together their interaction syndemic analyzed. Plausible lacunae also highlighted addition pointing need redefining new conceptual frameworks. Therefore, extraordinary state-ofthe-art reviews provides useful both experienced clinicians trainees as well academics steer clinical practice research management obesity irrespective setting or career stage.

Language: Английский

Citations

21
BMI-based obesity classification misses children and adolescents with raised cardiometabolic risk due to increased adiposity DOI Creative Commons
J. Karina Zapata, Cristina Azcona, Victoria Catalán

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 4, 2023

Abstract Objective To assess how inaccurately the body mass index (BMI) is used to diagnose obesity compared fat percentage (BF%) measurement and compare cardiometabolic risk in children adolescents with or without according BMI but a similar BF%. Methods A retrospective cross-sectional investigation was conducted including 553 (378 females/175 males) white aged 6–17 years, 197 normal weight (NW), 144 overweight (OW) 212 (OB) BMI. In addition BMI, BF% measured by air displacement plethysmography, as well markers of had been determined existing cohort. Results We found that 7% subjects considered NW 62% classified OW presented within range. Children criterion exhibited higher blood pressure C-reactive protein (CRP) boys, pressure, glucose, uric acid, CRP cells count, reduced HDL-cholesterol, girls, those Importantly, both groups showed similarly altered glucose homeostasis after an OGTT their counterparts. Conclusions from present study suggest increased factors based on Being aware difficulty determining composition everyday clinical practice, our data show its inclusion could yield clinically useful information for diagnosis treatment obesity.

Language: Английский

Citations

21
Precision medicine of obesity as an integral part of type 2 diabetes management – past, present, and future DOI
Łukasz Szczerbiński, José C. Florez

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(11), P. 861 - 878

Published: Oct. 4, 2023

Language: Английский

Citations

18
Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors DOI Open Access
Min Wang, Yang Ou,

Xiang-Lian Yuan

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(1), P. 53 - 71

Published: Jan. 12, 2024

BACKGROUND The lack of specific predictors for type-2 diabetes mellitus (T2DM) severely impacts early intervention/prevention efforts. Elevated branched-chain amino acids (BCAAs: Isoleucine, leucine, valine) and aromatic (AAAs: Tyrosine, tryptophan, phenylalanine)) show high sensitivity specificity in predicting animals predict T2DM 10-19 years before onset clinical studies. However, improvement is needed to support its utility. AIM To evaluate the effects body mass index (BMI) sex on BCAAs/AAAs new-onset individuals with varying weight. METHODS Ninety-seven patients (< 12 mo) differing BMI [normal weight (NW), n = 33, 22.23 ± 1.60; overweight, 42, 25.9 1.07; obesity (OB), 22, 31.23 2.31] from First People’s Hospital Yunnan Province, Kunming, China, were studied. One-way 2-way ANOVAs conducted determine BCAAs/AAAs. RESULTS Fasting serum AAAs, BCAAs, glutamate, alanine greater high-density lipoprotein (HDL) was lower (P < 0.05, each) OB-T2DM than NW-T2DM patients, especially male patients. Arginine, histidine, methionine, lysine female Moreover, alanine, lysine, valine, isoleucine, tyrosine, phenylalanine, tryptophan significantly correlated abdominal adiposity, BMI, whereas leucine phenylalanine negatively HDL. CONCLUSION Heterogeneously elevated acids, BCAAs/AAAs, across categories revealed a potentially skewed prediction development. higher BCAA/AAA levels obese would individuals, may underestimate risk NW individuals. This should be considered when are used as predictor.

Language: Английский

Citations

8