Metabolic engineering for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from glucose and propionic acid in recombinant Escherichia coli DOI
Dong Meng,

Changfeng Miao,

Yuling Liu

et al.

Bioresource Technology, Journal Year: 2022, Volume and Issue: 348, P. 126786 - 126786

Published: Feb. 1, 2022

Language: Английский

Recent advances and future prospects of cellulose, starch, chitosan, polylactic acid and polyhydroxyalkanoates for sustainable food packaging applications DOI
Satti Venu Gopala Kumari,

Kannan Pakshirajan,

G. Pugazhenthi

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 221, P. 163 - 182

Published: Sept. 5, 2022

Language: Английский

Citations

133

Towards the Sustainability of the Plastic Industry through Biopolymers: Properties and Potential Applications to the Textiles World DOI Open Access
Antonella Patti, Domenico Acierno

Polymers, Journal Year: 2022, Volume and Issue: 14(4), P. 692 - 692

Published: Feb. 11, 2022

This study aims to provide an overview of the latest research studies on use biopolymers in various textile processes, from spinning processes dyeing and finishing treatment, proposed as a possible solution reduce environmental impact industry. Recently, awareness polluting aspects production, based petroleum derivatives, has grown significantly. Environmental issues resulting greenhouse gas emissions, waste accumulation nature landfills, have pushed activities toward more sustainable, low-impact alternatives. Polymers derived renewable resources and/or with biodegradable characteristics were investigated follows: (i) constituent materials yarn view their superior ability be decomposed compared common synthetic petroleum-derived plastics, positive antibacterial activities, good breathability, mechanical properties; (ii) act biological catalysts; (iii) impart specific functional properties treated textiles; (iv) 3D printing technologies fabric surfaces replace traditionally pollutive dye-based inkjet printing; (v) implants for treatment dye-contaminated water. Finally, current projects led by well-known companies development new market are presented.

Language: Английский

Citations

87

Spiro-salen catalysts enable the chemical synthesis of stereoregular polyhydroxyalkanoates DOI
Hao‐Yi Huang, Wei Xiong, Yuting Huang

et al.

Nature Catalysis, Journal Year: 2023, Volume and Issue: 6(8), P. 720 - 728

Published: Aug. 10, 2023

Language: Английский

Citations

46

Electrospun radially oriented berberine-PHBV nanofiber dressing patches for accelerating diabetic wound healing DOI Creative Commons
Qiuyu Wang, Sai Zhang, Jiayi Jiang

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract A dressing patch made of radially oriented poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers was successfully manufactured with a modified electrospinning strategy. The as-electrospun PHBV nanofiber exhibited uniform and bead-free nanofibrous morphology innovative arrangement, which demonstrated to possess obviously improved mechanical property, increased surface hydrophilicity enhanced biological properties compared the control traditionally randomly pattern. Interestingly, it found that pattern could induce cell migration from periphery center along in rapid manner. To further improve biofunction patch, berberine (Beri, an isoquinoline alkaloid) two different concentrations were encapsulated into during electrospinning, present sustained drug release behavior for nearly one month. Importantly, addition Beri impart excellent anti-inflammatory property by significantly inhibiting secretion pro-inflammatory factors M1 macrophages, also showed additive influence on promoting proliferation human dermal fibroblasts (HDFs), as well growth E. coli, S. aureus C. albicans, Beri-free patch. In animal studies, electrospun loading high content accelerate healing process diabetic mouse full-thickness skin wound shortened time (100% closure rate after 18 days’ treatment) quality (improved collagen deposition, re-epithelialization neovascularization hair follicles). all, this study reported therapeutic strategy integrating physical cues multiple effective treatment hard-to-heal wounds.

Language: Английский

Citations

33

Production of Polyhydroxyalkanoates for Biodegradable Food Packaging Applications Using Haloferax mediterranei and Agrifood Wastes DOI Creative Commons
Lorena Atarés, Amparo Chiralt, Chelo González‐Martínez

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 950 - 950

Published: March 20, 2024

Polyhydroxyalkanoates (PHAs) are high-value biodegradable polyesters with thermoplastic properties used in the manufacturing of different products such as packaging films. PHAs have gained much attention from researchers and industry because their biobased nature appropriate features, similar to conventional synthetic plastics. This review aims discuss some recent solutions challenges associated PHA production. The implementation a cost-effective process is presented by following strategies, use inexpensive carbon sources, selection high-producing microorganisms, functionalization final materials make them suitable for food applications, among others. Research efforts needed improve economic viability production at large scale. Haloferax mediterranei promising producer due its ability grow non-sterile conditions possibility using seawater prepare growth medium. Additionally, downstream processing extraction can be simplified treating H. cells pure water. Further research should focus on optimization recycling effluents side streams reutilization desalinization an integrated part biotechnological

Language: Английский

Citations

22

Carbon Cycle of Polyhydroxyalkanoates (CCP): Biosynthesis and Biodegradation DOI
Siqin Zhang, Huishu Yuan, Xue Ma

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120904 - 120904

Published: Jan. 1, 2025

Language: Английский

Citations

2

A Review on Curcumin-Loaded Electrospun Nanofibers and their Application in Modern Medicine DOI Creative Commons

Souradeep Mitra,

Tarun Mateti, Seeram Ramakrishna

et al.

JOM, Journal Year: 2022, Volume and Issue: 74(9), P. 3392 - 3407

Published: Feb. 24, 2022

Herbal drugs are safe and show significantly fewer side effects than their synthetic counterparts. Curcumin (an active ingredient primarily found in turmeric) shows therapeutic properties, but its commercial use as a medication is unrealized, because of doubts about potency. The literature reveals that electrospun nanofibers simplicity, efficiency, cost, reproducibility compared to other fabricating techniques. Forcespinning new technique minimizes limitations provides additional advantages electrospinning. Polymer-based nanofibers-whose lie stability, solubility, drug storage-overcome problems related delivery, like instability hydrophobicity. Curcumin-loaded polymer potency healing diabetic wounds vitro vivo. release profiles, cell viability, proliferation assays substantiate efficacy bone tissue repair delivery against lung, breast, colorectal, squamous, glioma, endometrial cancer cells. This review mainly discusses how interact with curcumin medical efficacy.

Language: Английский

Citations

54

Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering DOI Open Access
Thiruchelvi Pulingam, Jimmy Nelson Appaturi, Thaigarajan Parumasivam

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(11), P. 2141 - 2141

Published: May 24, 2022

Tissue engineering technology aids in the regeneration of new tissue to replace damaged or wounded tissue. Three-dimensional biodegradable and porous scaffolds are often utilized this area mimic structure function extracellular matrix. Scaffold material design significant areas biomaterial research most favorable for seeding vitro vivo cells. Polyhydroxyalkanoates (PHAs) biopolyesters (thermoplastic) that appropriate application due their biodegradability, thermo-processability, enhanced biocompatibility, mechanical properties, non-toxicity, environmental origin. Additionally, they offer enormous potential modification through biological, chemical physical alteration, including blending with various other materials. PHAs produced by bacterial fermentation under nutrient-limiting circumstances have been reported perspectives devices biological applications. The present review discusses applications conventional medical devices, especially soft (sutures, wound dressings, cardiac patches blood vessels) hard (bone cartilage scaffolds) paper also addresses a recent advance highlighting usage implantable such as heart valves, stents, nerve guidance conduits nanoparticles, drug delivery. This summarizes biodegradability conducts an overview current scientific achievements development biomedical sector. In future, may synthetic plastics choice researchers practitioners.

Language: Английский

Citations

49

Advances in Polyhydroxyalkanoate Nanocarriers for Effective Drug Delivery: An Overview and Challenges DOI Creative Commons
Priyanka Prakash, Wing‐Hin Lee,

Ching-Yee Loo

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(1), P. 175 - 175

Published: Jan. 5, 2022

Polyhydroxyalkanoates (PHAs) are natural polymers produced under specific conditions by certain organisms, primarily bacteria, as a source of energy. These up-and-coming bioplastics an undeniable asset in enhancing the effectiveness drug delivery systems, which demand characteristics like non-immunogenicity, sustained and controlled release, targeted delivery, well high loading capacity. Given their biocompatibility, biodegradability, modifiability, compatibility with hydrophobic drugs, PHAs often provide superior alternative to free therapy or treatments using other polymeric nanocarriers. The many formulation methods existing PHA nanocarriers, such emulsion solvent evaporation, nanoprecipitation, dialysis, situ polymerization, explained this review. Due flexibility that allows for vessel tailormade its intended application, nanocarriers have found place diverse options anticancer anti-infective treatments, among applications discussed article. Despite positive attributes, advancement clinical trials has been stunted due polymers’ hydrophobicity, controversial production materials, costs, others. challenges explored review, alongside solutions alternatives.

Language: Английский

Citations

47

Polyhydroxyalkanoate recovery overview: properties, characterizations, and extraction strategies DOI Creative Commons

Teresa Abate,

Claudia Amabile, Raúl Muñoz

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 356, P. 141950 - 141950

Published: April 8, 2024

Due to their excellent properties, polyhydroxyalkanoates are gaining increasing recognition in the biodegradable polymer market. These biogenic polyesters characterized by high biodegradability multiple environments, overcoming limitation of composting plants only and versatility production. The most consolidated techniques literature or reference legislation for physical, chemical mechanical characterisation final product reported since its usability on market is still linked quality, including certificate. This makes a promising prospect with potential replace fossil-based thermoplastics sustainably. review analyses compares properties poly-β-hydroxybutyrate poly-β-hydroxybutyrate-co-β-hydroxyvalerate, indicating current limitations strengths. In particular, copolymer characterised better performance terms crystallinity, hardness workability. However, knowledge this area infancy, selling prices too (9 18 $ kg-1). An analysis main extraction techniques, established development, also included. Solvent currently widely used method due efficiency quality. context, phase biopolymer production process remains major challenge costs need use non-halogenated toxic solvents improve good-quality bioplastics. discusses all fundamental parameters optimising process, such as solubility temperature.

Language: Английский

Citations

13