A biomarkers study of human skin fibroblasts exposition to glyphosate-based herbicide using an untargeted and targeted metabolomics approach DOI

Josimar M. Batista,

Dawidson Assis Gomes, María José González Armijos

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 370, P. 143998 - 143998

Published: Dec. 22, 2024

Language: Английский

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism DOI Creative Commons
Udayadharshini Subaramaniyam,

Rethi Saliya Allimuthu,

Shanu Vappu

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: June 26, 2023

Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially fish. Fish is a staple affordable food source, rich animal protein, along with various vitamins, essential amino acids, minerals. Exposure of fish to microplastics, pesticides, nanoparticles generates ROS induces oxidative stress, inflammation, immunotoxicity, genotoxicity, DNA damage alters gut microbiota, thus reducing growth quality Changes behavioral patterns, swimming, feeding habits were also observed under exposures above contaminants. These affect Nrf-2, JNK, ERK, NF-κB, MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes Effects found modulate antioxidant enzymes, including superoxide dismutase, catalase, glutathione system. So, protect health from contribution nano-technology or nano-formulations was researched. A decrease nutritional population significantly impacts human diet, influencing traditions economics worldwide. On other hand, traces microplastics habitat water can enter humans by consuming contaminated may result serious hazards. This review summarizes stress caused due nano-particle contamination exposure their impact health. As rescue mechanism, use management disease discussed.

Language: Английский

Citations

83

Tea polyphenols alleviate TBBPA-induced inflammation, ferroptosis and apoptosis via TLR4/NF-κB pathway in carp gills DOI
Ran Xu,

Fu-xin Han,

Hongru Wang

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 146, P. 109382 - 109382

Published: Jan. 18, 2024

Language: Английский

Citations

23

Aquatic ecotoxicity of glyphosate, its formulations, and co-formulants: evidence from 2010 to 2023 DOI Creative Commons
Szandra Klátyik, G. Simon,

Marianna Oláh

et al.

Environmental Sciences Europe, Journal Year: 2024, Volume and Issue: 36(1)

Published: Feb. 6, 2024

Abstract Glyphosate (GLY), the most widely used herbicide active ingredient (AI) in world, is frequently detected aquatic environments where it can affect non-target organisms. Globally, more than 2000 commercial GLY-based herbicides (GBHs) are to control weeds. Non-target organisms exposed complex pesticide formulations under real environmental conditions, but co-formulants contained GBHs classified as so-called inert and inactive ingredients terms of their biological effects. The main objective this comprehensive review compile results ecotoxicological studies on side-effects GLY, GBHs, formulating agents. Based demonstrated for a variety plant animal organisms, oxidative stress appears be major trigger these adverse effects, affecting integrity DNA other biochemical functions. Furthermore, there evidence impairment various physiological behavioral Adverse effects GLY have been observed even at very low concentrations. There also differences sensitivity tested, with similar lifestyles, habitats or identical taxa. typically investigate short-term single exposure GLY/GBH species, whilst reality multiple applications together pesticides common during cropping cycle. Moreover, interactions between GLY/GBHs contaminants rarely studied. Higher toxicity compared alone has often observed, demonstrating that highly toxic own markedly increase GBH formulation. possible impurities such heavy metals, cause additional problems environment food safety. widespread massive use leads increased hazards. In addition, need revision risk assessment system emphasized. According studies, current pollution by problematic cannot considered environmentally sustainable. It is, therefore, necessary least tighten permitted forms use.

Language: Английский

Citations

23

Glyphosate-based herbicide: Impacts, detection, and removal strategies in environmental samples DOI
Olutobi Daniel Ogunbiyi, Damilola O. Akamo, Esther Ebunoluwa Oluwasanmi

et al.

Groundwater for Sustainable Development, Journal Year: 2023, Volume and Issue: 22, P. 100961 - 100961

Published: May 16, 2023

Language: Английский

Citations

21

Ameliorating effects of natural herbal supplements against water-borne induced toxicity of heavy metals on Nile tilapia, (Oreochromis niloticus) DOI Creative Commons

Arzoo Fatima,

Syed Makhdoom Hussain, Shafaqat Ali

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 29, 2024

Abstract The efficacy of herbal supplements in mitigating heavy metals (HMs) toxicity was investigated using a widely grown fish, the Nile tilapia ( Oreochromis niloticus ). experiment conducted over two phases: during stress phase, experimental fishes were exposed to sub-lethal concentrations HMs, including lead, cadmium, zinc, and copper for 15 days; following which feeding given 70 days ameliorate their effects. Seven groups established: control negative group (CON−ve), positive (CON+ve, without any treatment), five with supplementation 1% turmeric (TUR), cinnamon (CIN), ginger (GIN), garlic (GAR), mixture (MIX), respectively. A total 315 distributed evenly tanks (15 per tank, triplicates). results revealed that exposure HMs led significant p < 0.05) alterations all tested parameters, i.e., liver damage growth reduction. supplements, especially MIX groups, ameliorated harmful effects restored fish growth, digestibility, carcass composition, health. In conclusion, study demonstrated effective reducing HMs-linked tilapia. Future studies pertaining mechanisms facilitated by various bioactive substances-linked tolerance are warranted.

Language: Английский

Citations

4

Effects of ginger (Zingiber officinale) on the growth performance, digestive enzyme activity, antioxidative response, and antibacterial capacity of striped catfish (Pangasianodon hypophthalmus) reared in outdoor conditions DOI Creative Commons
Ahmed M. Ashry, Mahmoud M. Habiba,

Ahmed M. El-Zayat

et al.

Aquaculture Reports, Journal Year: 2023, Volume and Issue: 33, P. 101760 - 101760

Published: Oct. 6, 2023

Unstable outdoor farming conditions weaken fish's health status and immunity, leading to high susceptibility infectious diseases low productivity. Feed additives have been applied recently enhance the growth performance well-being of striped catfish. This study evaluated effects ginger (Zingiber officinale) on performance, digestive enzyme activity, antioxidative response, antibacterial capacity Control three test diets were supplemented with rhizomes powder at 0.5 %, 1 1.5 %. After 90 days, catfish fed dietary was marginally increased, highest being in group receiving % (p < 0.05). However, feed conversion ratio reduced following same trend, lowest fish Fish had hormone level than remaining groups The carcass composition, including total protein lipids, meaningfully affected by ginger, while ash fibers unaffected. Amylase, protease, lipase activities significantly higher control. protein, albumin, globulin 0 Superoxide dismutase, catalase, glutathione peroxidase regardless dose. On other hand, malondialdehyde (MDA) markedly catfish, those who received MDA level. Vibrio spp. fecal coliform intestines. Interestingly count for coliform. Overall, based regression analysis results, should be added 1.02–1.58 show best well-being.

Language: Английский

Citations

9

Higher urinary glyphosate exposure is associated with increased risk of liver dysfunction in adults: An analysis of NHANES, 2013–2016 DOI

Tuo Xiao,

Yuhao Chen,

Yue Xu

et al.

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 19, 2023

Language: Английский

Citations

9

Usefulness of oxidative stress biomarkers in native species for the biomonitoring of pesticide pollution in a shallow lake of the Austral Pampas, Argentina DOI

Lucas Rodrigo Lombardero,

Débora Jesabel Pérez, Sandra Médici

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 353, P. 141578 - 141578

Published: Feb. 29, 2024

Language: Английский

Citations

3

Impacts of Voliam Flexi on Antioxidant Responses, Oxidative Stress, and Histopathological Changes in Juvenile African Catfish (Clarias gariepinus) DOI Creative Commons
Mohamed Hamed,

Hanem Abdel-Tawab,

Mostafa A. Abdel-Maksoud

et al.

Aquaculture Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

This study investigated the toxicological impact of Voliam Flexi (containing chlorantraniliprole and thiamethoxam) on juvenile African catfish ( Clarias gariepinus ), a species commonly exposed to pesticides in rice cultivation regions. toxic effects catfish, focusing oxidative stress, antioxidant enzyme disruption, tissue damage at environmentally relevant concentrations. Over 15‐day period, fish were pesticide concentrations applied Egyptian fields, specifically 43.5, 87.5, 175 mg/L. Antioxidant defense mechanisms, including GST (glutathione S‐transferase), SOD (superoxide dismutase), CAT (catalase), TAC (total capacity), measured alongside indicators such as lipid peroxidation (LPX) DNA fragmentation. A dose‐dependent reduction activity an increase observed, with higher leading elevated LPX levels Histopathological evaluations kidney spleen revealed significant degenerative changes, tubular damage, edema, pyknotic nuclei, particularly These findings suggest that poses considerable risks aquatic organisms, disrupting cellular functions, damage. The highlights potential threat runoff biodiversity calls for stricter environmental regulations mitigate these risks.

Language: Английский

Citations

0

The induced hepatotoxicity and genotoxicity in Oreochromis niloticus exposed to a newly released florpyrauxifen-benzyl herbicide DOI Creative Commons

Noura Nabet,

Elsayed A. Khallaf,

Alaa A. Alne-na-ei

et al.

Ecotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Abstract The investigation of the toxic potential a newly introduced herbicide, Florpyrauxifen-benzyl (FPX), on Nile tilapia ( Oreochromis niloticus ) was aim this study. For 96 h, median lethal concentration (LC 50 assessed in fish juveniles using Probit analysis following exposure to five concentrations FPX (2–3 ppm). investigating some mechanisms toxicity, were allocated into three groups (0, 0.27 and 0.54 ppm FPX) cut-off intervals at 7 15 days. Liver malondialdehyde (MDA) reduced glutathione (GSH) levels assessed. In addition, superoxide dismutase (SOD) catalase (CAT) evaluated both transcriptional enzymatic activity levels. Histopathological effects liver erythrocytic nuclear abnormalities (ENAs) monitored too. 96h-LC found be 2.61 ppm, revealing tilapia. Concentrations induced oxidative stress by altering activities antioxidant enzymes their transcripts. genotoxic effect evidenced significant P < 0.05) increase micronuclei (MNs) ENA frequencies. Significant histopathological alterations observed concentrations, with highest FPX. Results suggest that may exert oxidative, genotoxic, non-targeted species such as if it is used improperly. Although could an indicator for materials aquatic habitat, future studies other organisms, or durations are recommended.

Language: Английский

Citations

0