Clinica Chimica Acta, Journal Year: 2021, Volume and Issue: 523, P. 231 - 238
Published: Oct. 8, 2021
Language: Английский
Laboratory Medicine, Journal Year: 2022, Volume and Issue: 53(6), P. 545 - 551
Published: March 30, 2022
Metabolomics is a field of systems biology that draws on the scientific methods other groups to qualitatively or quantitatively characterize small molecule metabolites in organisms, revealing their interconnections with state organism at an overall relative macroscopic level. Diabetic kidney disease (DKD) well known as chronic metabolic disease, and metabolomics provides excellent platform for its clinical study. A growing number metabolomic analyses have revealed individuals DKD disturbances multiple substances bodies. With continuous development improvement analysis technology, application research also expanding. This review discusses recent progress early diagnosis, prognosis, pathogenesis level vivo.
Language: Английский
Citations
869
Metabolites, Journal Year: 2019, Volume and Issue: 9(4), P. 76 - 76
Published: April 18, 2019
The use of multiple omics techniques (i.e., genomics, transcriptomics, proteomics, and metabolomics) is becoming increasingly popular in all facets life science. Omics provide a more holistic molecular perspective studied biological systems compared to traditional approaches. However, due their inherent data differences, integrating platforms remains an ongoing challenge for many researchers. As metabolites represent the downstream products interactions between genes, transcripts, proteins, metabolomics, tools approaches routinely used this field could assist with integration these complex multi-omics sets. question is, how? Here we some answers (in terms methods, software databases) along variety recommendations list continuing challenges as identified during peer session on that was held at recent ‘Australian New Zealand Metabolomics Conference’ (ANZMET 2018) Auckland, (Sept. 2018). We envisage document will serve guide metabolomics researchers other members community wishing perform studies. also believe ideas may allow full promise integrated research and, ultimately, biology be realized.
Language: Английский
Citations
521
Metabolites, Journal Year: 2020, Volume and Issue: 10(1), P. 37 - 37
Published: Jan. 15, 2020
Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed hundreds to thousands metabolites, whereby the bioactivity can be represented by synergism between several metabolites. However, isolating every single compound from extract is not always possible due complex chemistry and presence most secondary metabolites at very low levels. Metabolomics has emerged in recent years as an indispensable tool analysis crude extracts, leading paradigm shift research. Analytical methods such mass spectrometry (MS) nuclear magnetic resonance (NMR) used comprehensively annotate constituents plant screening, discovery well quality control purposes those required phytomedicine. In this review, current advancements sample preparation, measurements, data presented alongside few case studies successful applications these processes product discovery.
Language: Английский
Citations
240
Nature Protocols, Journal Year: 2020, Volume and Issue: 15(8), P. 2519 - 2537
Published: June 24, 2020
Language: Английский
Citations
188
Metabolites, Journal Year: 2020, Volume and Issue: 10(12), P. 505 - 505
Published: Dec. 10, 2020
Adverse environmental conditions due to climate change, combined with declining soil fertility, threaten food security. Modern agriculture is facing a pressing situation where novel strategies must be developed for sustainable production and Biostimulants, conceptually defined as non-nutrient substances or microorganisms the ability promote plant growth health, represent potential provide economically favorable solutions that could introduce approaches improve agricultural practices crop productivity. Current knowledge phenotypic observations suggest biostimulants potentially function in regulating modifying physiological processes plants growth, alleviate stresses, quality yield. However, successfully develop biostimulant-based formulations programs, understanding biostimulant-plant interactions, at molecular, cellular levels, prerequisite. Metabolomics, multidisciplinary omics science, offers unique opportunities predictively decode mode of action on plants, identify signatory markers biostimulant action. Thus, this review intends highlight current scientific efforts gaps research industry, context promotion stress responses. The firstly revisits models have been elucidated describe molecular machinery employed by coping stresses. Furthermore, definitions, claims applications are pointed out, also indicating lack biological basis accurately postulate mechanisms biostimulants. articulates briefly key aspects metabolomics workflow (potential) science industry.
Language: Английский
Citations
181
Metabolites, Journal Year: 2019, Volume and Issue: 9(6), P. 108 - 108
Published: June 6, 2019
Metabolomics is one of the latest omics technologies that has been applied successfully in many areas life sciences. Despite being relatively new, a plethora publications over years have exploited opportunities provided through this data and question driven approach. Most importantly, metabolomics studies produced great breakthroughs biomarker discovery, identification novel metabolites more detailed characterisation biological pathways organisms. However, translation research outcomes into clinical tests user-friendly interfaces hindered due to factors, some which outlined hereafter. This position paper summary discussion on translational undertaken during peer session Australian New Zealand Conference (ANZMET 2018) held Auckland, Zealand. Here, we discuss key including existing challenges suggested solutions, as well how expand industrial application metabolomics. In addition, share our perspective full capability can be explored.
Language: Английский
Citations
170
Bioanalysis, Journal Year: 2019, Volume and Issue: 11(24), P. 2297 - 2318
Published: Dec. 1, 2019
Metabolomics is the comprehensive study of small-molecule metabolites. Obtaining a wide coverage metabolome challenging because broad range physicochemical properties small molecules. To compounds interest spectroscopic (NMR), spectrometric (MS) and separation techniques (LC, GC, supercritical fluid chromatography, CE) are used. The choice for given technique influenced by sample matrix, concentration metabolites, amount sample. This review discusses most commonly used analytical metabolomic studies, including their advantages, drawbacks some applications.
Language: Английский
Citations
170
RSC Advances, Journal Year: 2020, Volume and Issue: 10(6), P. 3092 - 3104
Published: Jan. 1, 2020
Metabolomics is the study of investigation small molecules derived from cellular and organism metabolism, which reflects outcomes complex network biochemical reactions in living systems.
Language: Английский
Citations
154
Mass Spectrometry Reviews, Journal Year: 2021, Volume and Issue: 41(5), P. 722 - 765
Published: Feb. 1, 2021
Abstract Researchers worldwide are taking advantage of novel, commercially available, technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and lipidomics applications in a variety fields including life, biomedical, food sciences. IM‐MS provides three main technical advantages over traditional LC‐MS workflows. Firstly, addition to mass, allows collision cross‐section values be measured metabolites lipids, physicochemical identifier related the chemical shape an analyte that increases confidence identification. Second, peak capacity signal‐to‐noise, improving fingerprinting well quantification, better defining spatial localization lipids biological samples. Third, can coupled with various fragmentation modes, adding new tools improve structural characterization molecular annotation. Here, we review state‐of‐the‐art technologies approaches utilized support assess challenges opportunities this growing field.
Language: Английский
Citations
133
Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(6), P. 2500 - 2529
Published: April 17, 2023
Phytobioactive compounds are plant secondary metabolites and bioactive abundantly present in medicinal plants have remarkable therapeutic potential. Oxidative stress antibiotic resistance major causes of present-day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, inflammation. The data for this review were collected from Google Scholar, PubMed, Directory Open Access Journals (DOAJ), Science Direct by using keywords: "Medicinal plants, compounds, Polyphenols, Alkaloids, Carotenoids etc." Several studies reported the pharmacological potential phytobioactives. alkaloids, terpenes, polysaccharides isolated showed antioxidant, anticancer, cytotoxic, anti-inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, antidiabetic activities. This literature was planned to provide comprehensive insight into biopharmacological phytobioactive compounds. techniques used extraction isolation bioassays required their biological activities antimicrobial, cytotoxic activities, been discussed. Characterization structural elucidation HPLC, TLC, FTIR, GC-MS/MS, NMR also concludes that may be alternative synthetic agents treatment various diseases.
Language: Английский
Citations
112