Triclosan exposure, transformation, and human health effects

Journal of Toxicology and Environmental Health Part B, Journal Year: 2017, Volume and Issue: 20(8), P. 447 - 469

Published: Nov. 17, 2017

Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the US population likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following risk assessment by Food Drug Administration (FDA). However, still remains, at high concentrations, in other such as toothpaste, mouthwash, hand sanitizer, surgical soaps. readily absorbed into human skin oral mucosa found various tissues fluids. The aim review describe exposure routes levels well metabolism transformation processes. burgeoning literature on health effects associated with exposure, reproductive problems, also summarized.

Language: Английский

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Occurrence and fate of antibiotic, analgesic/anti-inflammatory, and antifungal compounds in five wastewater treatment processes

The Science of The Total Environment, Journal Year: 2013, Volume and Issue: 473-474, P. 235 - 243

Published: Dec. 25, 2013

Language: Английский

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Distribution, Variability, and Predictors of Urinary Concentrations of Phenols and Parabens among Pregnant Women in Puerto Rico

Environmental Science & Technology, Journal Year: 2013, Volume and Issue: 47(7), P. 3439 - 3447

Published: March 7, 2013

Puerto Rico has higher rates of a range endocrine-related diseases and disorders compared to the United States. However, little is known date about human exposures or potential endocrine disrupting chemicals (EDCs) in Rico. We recruited 105 pregnant women Northern who provided urine samples questionnaire data at three times (18 ± 2, 22 26 2 weeks) during gestation. measured urinary concentrations five phenols parabens: 2,4-dichlorophenol (24-DCP), 2,5-dichlorophenol (25-DCP), benzophenone-3 (BP-3), bisphenol A (BPA), triclosan (TCS), butyl paraben (B-PB), methyl (M-PB), propyl (P-PB). The frequent detection these suggests that exposure highly prevalent among Rican women. Urinary TCS, BP-3, 25-DCP were than reproductive age US general population, while BPA, 24-DCP, parabens similar. Intraclass correlation coefficients (ICC) varied widely between biomarkers; BPA had lowest ICC (0.24) BP-3 highest (0.62), followed by (0.49) TCS (0.47). found positive associations biomarker with self-reported use liquid soap sunscreen lotion (BP-3 parabens), cosmetics (parabens). Our results can inform future epidemiology studies strategies reduce their precursors.

Language: Английский

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On the Need and Speed of Regulating Triclosan and Triclocarban in the United States

Environmental Science & Technology, Journal Year: 2014, Volume and Issue: 48(7), P. 3603 - 3611

Published: March 3, 2014

The polychlorinated aromatic antimicrobials triclosan and triclocarban are in widespread use for killing microorganisms indiscriminately, rapidly, by nonspecific action. While their utility healthcare settings is undisputed, benefits to users of antimicrobial personal care products few none. Yet, these latter, high-volume uses have caused contamination the environment, wildlife, human populations. This feature article presents a timeline scientific evidence regulatory actions U.S. concerning persistent biocides, showing potential path forward judicious sustainable synthetic antimicrobials, including design greener safer next-generation alternatives.

Language: Английский

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Exposure determinants of phthalates, parabens, bisphenol A and triclosan in Swedish mothers and their children

Environment International, Journal Year: 2014, Volume and Issue: 73, P. 323 - 333

Published: Sept. 16, 2014

Chemicals such as phthalates, parabens, bisphenol A (BPA) and triclosan (TCS), used in a wide variety of consumer products, are suspected endocrine disrupters although their level toxicity is thought to be low. Combined exposure may occur through ingestion, inhalation dermal exposure, toxic well combined effects poorly understood. The objective the study was estimate these chemicals Swedish mothers children (6–11 years old) investigate potential predictors exposure. Urine samples from 98 mother–child couples living either rural or an urban area were analyzed for concentrations four metabolites di-(2-ethylhexyl) phthalate (DEHP), three di-iso-nonyl (DiNP), mono-ethyl (MEP), mono-benzyl (MBzP) mono-n-butyl (MnBP), methylparaben (MetP), ethylparaben (EthP), propylparaben (ProP), butylparaben, benzylparaben, BPA, TCS. Information on sociodemographics, food consumption habits use personal care obtained via questionnaire, associations between urinary levels factors. There fairly good correlations biomarker children. had generally higher phthalates (geometric mean ΣDEHP 65.5 μg/L; ΣDiNP 37.8 MBzP 19.9 MnBP 76.9 μg/L) than (ΣDEHP 38.4 33.8 12.8 63.0 μg/L). Conversely, mother's parabens (MetP ProP 13.9 MEP (43.4 children's 6.8 2.1 (28.8 low molecular weight among (MBzP p = < 0.001; 0.001–0.002), which probably due presence PVC floorings wall coverings this area, whereas 0.003; 0.004) area. high associated with certain foods (i.e. chocolate ice cream) cosmetics products.

Language: Английский

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Triclosan: A Widespread Environmental Toxicant with Many Biological Effects

The Annual Review of Pharmacology and Toxicology, Journal Year: 2016, Volume and Issue: 56(1), P. 251 - 272

Published: Jan. 6, 2016

Triclosan (TCS) is a broad-spectrum antimicrobial agent that has been added to personal care products, including hand soaps and cosmetics, impregnated in numerous different materials ranging from athletic clothing food packaging. The constant disposal of TCS into the sewage system creating major environmental public health hazard. Owing its chemical properties bioaccumulation resistance degradation, widely detected various compartments concentrations nanograms micrograms per liter. Epidemiology studies indicate significant levels are body fluids all human age groups. We document here emerging evidence—from vitro vivo animal toxicology studies—demonstrating exerts adverse effects on biological systems through modes action. Considering fact humans simultaneously exposed many TCS-like chemicals, we speculate TCS-induced may be relevant health.

Language: Английский

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Emerging environmental contaminants: Challenges facing our next generation and potential engineering solutions

Environmental Technology & Innovation, Journal Year: 2017, Volume and Issue: 8, P. 40 - 56

Published: April 17, 2017

Language: Английский

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The impact of triclosan on the spread of antibiotic resistance in the environment

Frontiers in Microbiology, Journal Year: 2015, Volume and Issue: 5

Published: Jan. 15, 2015

Triclosan (TCS) is a commonly used antimicrobial agent that enters wastewater treatment plants (WWTPs) and the environment. An estimated 1.1x105 to 4.2x105 kg of TCS are discharged from these WWTPs per year in United States. The abundance along with its properties have given rise concern regarding impact on antibiotic resistance objective this review assess state knowledge multidrug environmental settings, including engineered environments such as anaerobic digesters. Pure culture studies reviewed paper gain insight into substantially smaller body research surrounding impacts microbial communities. studies, mainly pathogenic strains bacteria, demonstrate often associated resistance. Research lacking quantify current discharge environment, but it known can increase communities exposed TCS. plans proposed quantitatively define conditions under which selects for

Language: Английский

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Synthetic organic compounds and their transformation products in groundwater: Occurrence, fate and mitigation

The Science of The Total Environment, Journal Year: 2014, Volume and Issue: 503-504, P. 32 - 47

Published: June 25, 2014

Language: Английский

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Occurrence, distribution, bioaccumulation, and ecological risk of bisphenol analogues, parabens and their metabolites in the Pearl River Estuary, South China

Ecotoxicology and Environmental Safety, Journal Year: 2019, Volume and Issue: 180, P. 43 - 52

Published: May 7, 2019

Language: Английский

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