Viral Dynamics and Real-Time RT-PCR Ct Values Correlation with Disease Severity in COVID-19

Diagnostics, Journal Year: 2021, Volume and Issue: 11(6), P. 1091 - 1091

Published: June 15, 2021

Real-time RT-PCR is considered the gold standard confirmatory test for coronavirus disease 2019 (COVID-19). However, many scientists disagree, and it essential to understand that several factors variables can cause a false-negative test. In this context, cycle threshold (Ct) values are being utilized diagnose or predict SARS-CoV-2 infection. This practice has significant clinical utility as Ct be correlated with viral load. addition, have strong correlation multiple haematological biochemical markers. consider might affected by pre-analytic, analytic, post-analytical such collection technique, specimen type, sampling time, kinetics, transport storage conditions, nucleic acid extraction, RNA load, primer designing, real-time PCR efficiency, value determination method. Therefore, understanding interpretation of other influential could play crucial role in interpreting load severity. studies consisting small large sample sizes, discrepancies exist regarding positive between severity COVID-19. revised review literature been conducted fill knowledge gaps correlations severity/fatality rates patients Various databases PubMed, Science Direct, Medline, Scopus, Google Scholar were searched up April 2021 using keywords including “RT-PCR load”, “SARS-CoV-2 RT-PCR”, “Ct COVID-19”. Research articles extracted selected independently authors included present based on their relevance study. The current narrative explores mortality, progression, severity, infectivity. We also discuss affect these values, type swab, method, etc.

Language: Английский

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Poultry Production and Sustainability in Developing Countries under the COVID-19 Crisis: Lessons Learned

Animals, Journal Year: 2022, Volume and Issue: 12(5), P. 644 - 644

Published: March 3, 2022

Poultry farming is a significant source of revenue generation for small farmers in developing countries. It plays vital role fulfilling the daily protein requirements humans through meat and eggs consumption. The recently emerged pandemic Coronavirus Disease-19 (COVID-19) impacts poultry production sector. Although whole world affected, these may be more severe countries due to their dependency on exporting necessary supplies such as feed, vaccines, drugs, utensils. In this review, we have discussed under COVID-19 crisis measures regain loss industries. Generally, lockdown, trade limitations negatively impacted industries, which might exacerbate global poverty. Coordinated activities taken at private government levels arrange soft loans so that farms can restore marketing normal levels. addition, here, focused supply farm input, other raw materials, management system, improved breeding efficiency, veterinary services, egg meat, ensured secure sustainable chain.

Language: Английский

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Influence of COVID-19 on the poultry production and environment

Environmental Science and Pollution Research, Journal Year: 2021, Volume and Issue: 28(33), P. 44833 - 44844

Published: July 9, 2021

Abstract Although chickens are not susceptible to SARS-CoV-2, several coronavirus disease outbreaks have been described concerning poultry processing facilities in different countries. The COVID-19 pandemic and the developed strain caused 2nd, 3rd, recent Indian waves of epidemics that led unexpected consequences, such as forced reductions demands for some industries, transportation systems, employment, businesses due public confinement. Besides, plants' conditions exacerbate risks proximity on line, cold, humidity. Most workers do access paid sick time or adequate health care, because low wages, they limited reserves enable them leave steady employment. In addition, meat slaughterhouses may be infected through respiratory droplets air and/or from touching dirty surfaces objects workstations, break room tables, tools. Egg prices increased dramatically during lockdown consumers started change their behaviors habits. COVID might also substantially impact international trade over next months. This review will focus effect production, environmental sustainability, earth systems process points view.

Language: Английский

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NSAIDs/nitazoxanide/azithromycin repurposed for COVID-19: potential mitigation of the cytokine storm interleukin-6 amplifier via immunomodulatory effects

Expert Review of Anti-infective Therapy, Journal Year: 2021, Volume and Issue: 20(1), P. 17 - 21

Published: June 5, 2021

Mediators of immunity and inflammation are playing a crucial role in COVID-19 pathogenesis complications as demonstrated by several genetic clinical studies. Thus, repurposing drugs that possess anti-inflammatory and/or immune-modulatory effects for is considered rational approach.

Language: Английский

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Psychological Distress and Work Environment Perception by Physical Therapists from Southern Italy during COVID-19 Pandemic: The C.A.L.A.B.R.I.A Study

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(18), P. 9676 - 9676

Published: Sept. 14, 2021

The psychosocial impact of the work environment during COVID-19 pandemic on health professionals is a growing issue. present study examined specific indicators pandemic, through multiple regression model self-administered cross-sectional online survey in cohort physical therapists from region Southern Italy March 2020 to May 2021. questionnaire contained items and healthcare issues related COVID-19. Eighty (29 male 51 female), mean age 32.5 ± 10.1 years, were involved this survey. analysis showed that “management activity” was significantly correlated “therapist frustration” (ΔR2 = 0.16; p < 0.03). Findings underline importance healthy enhance job satisfaction all avoid role conflict burnout syndrome pandemic.

Language: Английский

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Quantum dots against SARS‐CoV‐2: diagnostic and therapeutic potentials

Journal of Chemical Technology & Biotechnology, Journal Year: 2022, Volume and Issue: 97(7), P. 1640 - 1654

Published: Jan. 21, 2022

The application of quantum dots (QDs) for detecting and treating various types coronaviruses is very promising, as their low toxicity high surface performance make them superior among other nanomaterials; in conjugation with fluorescent probes they are promising semiconductor nanomaterials the detection cellular processes viral infections. In view successful results inhibiting SARS-CoV-2, functional QDs could serve eminent role growth safe nanotherapy cure infections near future; large areas help bind numerous molecules post-synthetically. Functionalized functionality, targeted selectivity, stability less cytotoxicity can be employed highly sensitive co-delivery imaging/diagnosis. Besides, due to importance safety issues, prepared from plant sources (e.g. curcumin) much more attractive, provide good biocompatibility toxicity. this review, recent developments pertaining diagnostic inhibitory potentials against SARS-CoV-2 deliberated including important challenges future outlooks. © 2022 Society Chemical Industry (SCI).

Language: Английский

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Key insights into recent advances and challenges in COVID-19 management

Deleted Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 15, 2025

SARS-CoV-2 infection, commonly called COVID-19, has taken a jump from being rarely talked about to becoming household name. Making it history as the 5th global pandemic, this public health crisis millions of lives all over world. Right identification patient zero, pandemic unfolded in waves triggering domino effect that impacted aspects life. Global efforts have been underway combat and minimize its repercussions, resulting development efficient vaccines drugs treat disease control spread infection. However, making benefits these available everyone walking path towards end remains challenge. Keeping view, review intends present summary sequential recent advancements field diagnostics treatment, challenges continue remain overcoming crisis. It can be understood task controlling managing impact such massive goes well beyond boundaries what present-day technology medicine care offer. A collaborative integrative approach between academic, scientific, social, economic factors, along with close supervision reinforcement current safety protocols, help ensure better management strategy progression COVID-19.

Language: Английский

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Antiviral Activities of Halogenated Emodin Derivatives against Human Coronavirus NL63

Molecules, Journal Year: 2021, Volume and Issue: 26(22), P. 6825 - 6825

Published: Nov. 11, 2021

The current COVID-19 outbreak has highlighted the need for development of new vaccines and drugs to combat Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Recently, various have been proposed as potentially effective against COVID-19, such remdesivir, infliximab imatinib. Natural plants used an alternative source thousands years, some them are treatment viral diseases. Emodin (1,3,8-trihydroxy-6-methylanthracene-9,10-dione) is a biologically active anthraquinone with antiviral activity that found in plants. We studied selectivity electrophilic aromatic substitution reactions on emodin core (halogenation, nitration sulfonation), which resulted library derivatives. main aim this work was carry out initial evaluation potential improve human coronavirus NL63 (HCoV-NL63) also generate set SAR guidelines. prepared derivatives displayed significant anti-HCoV-NL63 activity. observed halogenation can its most compound study iodinated analogue E_3I, whose comparable remdesivir. Evaluation analogues revealed unwanted toxicity Vero cells. Since synthetic routes now available allow modification structure, it reasonable expect significantly improved lowered may thus be generated.

Language: Английский

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Investigational antiviral drugs for the treatment of COVID-19 patients

Archives of Virology, Journal Year: 2022, Volume and Issue: 167(3), P. 751 - 805

Published: Feb. 9, 2022

Language: Английский

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The Psychological Impact of COVID-19 on Residents of Saudi Arabia

Psychology Research and Behavior Management, Journal Year: 2022, Volume and Issue: Volume 15, P. 1221 - 1234

Published: May 1, 2022

This study aimed to determine the stress levels and identify various factors responsible for causing high-stress scores during COVID-19 pandemic in Saudi population.This cross-sectional was conducted at Imam Abdulrahman Bin Faisal University, Dammam, from June 2020 until December on 4052 respondents Eastern province of Arabia. An online survey used collect information about factors. The psychological impact measured by using event scale (COVID-19 IES), whereas general were assessed K10 Kessler Psychological Distress Scale (K10).The outbreak revealed that 35.4% participants suffered moderate or severe (score>33); 19.7% had a mild (scores24-32), 44.9% reported minimal (score <23). significantly associated with higher IES included male gender, low monthly income, having private business, living apartments/residential complexes, poor health status, visit hospital/doctor past three months, presence chronic disease, direct/indirect contact someone diagnosed with/suspected have COVID-19, surfaces/tools infected getting screened quarantined follow-up latest news knowledge greater number people died (p < 0.05). In contrast, being an elementary school student, 4-10 children, observing protective measures, staying home 4-12 hours lower 0.05).During initial six months Arabia, impact. identified high scores. These findings can help formulate interventions improving scales vulnerable groups pandemic.

Language: Английский

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