Adverse Human Health Effects of Chromium by Exposure Route: A Comprehensive Review Based on Toxicogenomic Approach

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3410 - 3410

Published: Feb. 8, 2023

Heavy metals are defined as with relatively high density and atomic weight, their various applications have raised serious concerns about the environmental impacts potential human health effects. Chromium is an important heavy metal that involved in biological metabolism, but Cr exposure can induce a severe impact on occupational workers or public health. In this study, we explore toxic effects of through three routes: dermal contact, inhalation, ingestion. We propose underlying toxicity mechanisms based transcriptomic data bioinformatic tools. Our study provides comprehensive understanding different routes by diverse bioinformatics analyses.

Language: Английский

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Heavy Metals in Foods and Beverages: Global Situation, Health Risks and Reduction Methods

Foods, Journal Year: 2023, Volume and Issue: 12(18), P. 3340 - 3340

Published: Sept. 6, 2023

Heavy metals are chemical elements with a toxic effect on the human body. The expansion of industries has led to significant increasing levels these constituents in environment. Intensive agriculture can also lead an increased concentration heavy as result using different fertilizers and pesticides. metal accumulation soil plants represents serious issue because potential risks consumers. There several methods available for removal components from substrates (chemical precipitation, electrodialysis, coagulation flocculation, photocatalytic removal, adsorption-based processes), but most procedures expensive difficult perform. Thus, more research is needed development low-cost foods. This work review presence food (such fruits vegetables, milk dairy products, meat derivatives, oils, alcoholic beverages) provides overview current situation worldwide, taking into account fact that health induced by intensification industry high degree pollution. Considering toxicological quality affects its acceptability, this valuable data regarding actual proposed topic.

Language: Английский

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Toxicological and bioremediation profiling of nonessential heavy metals (mercury, chromium, cadmium, aluminium) and their impact on human health: A review

Annales de Toxicologie Analytique, Journal Year: 2024, Volume and Issue: 36(3), P. 205 - 234

Published: April 7, 2024

Language: Английский

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Heavy metals: toxicity and human health effects

Archives of Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Heavy metals are naturally occurring components of the Earth’s crust and persistent environmental pollutants. Human exposure to heavy occurs via various pathways, including inhalation air/dust particles, ingesting contaminated water or soil, through food chain. Their bioaccumulation may lead diverse toxic effects affecting different body tissues organ systems. The toxicity depends on properties given metal, dose, route, duration (acute chronic), extent bioaccumulation. detrimental impacts human health largely linked their capacity interfere with antioxidant defense mechanisms, primarily interaction intracellular glutathione (GSH) sulfhydryl groups (R-SH) enzymes such as superoxide dismutase (SOD), catalase, peroxidase (GPx), reductase (GR), other enzyme Although arsenic (As) is believed bind directly critical thiols, alternative hydrogen peroxide production processes have also been postulated. known signaling pathways affect a variety cellular processes, cell growth, proliferation, survival, metabolism, apoptosis. For example, cadmium can BLC-2 family proteins involved in mitochondrial death overexpression antiapoptotic Bcl-2 suppression proapoptotic (BAX, BAK) thus increasing resistance cells undergo malignant transformation. Nuclear factor erythroid 2-related 2 (Nrf2) an important regulator enzymes, level oxidative stress, oxidants has shown act double-edged sword response arsenic-induced stress. Another mechanism significant threats metal (e.g., Pb) involves substitution essential calcium (Ca), copper (Cu), iron (Fe)) structurally similar (Cd) (Pb)) metal-binding sites proteins. Displaced redox (copper, iron, manganese) from natural catalyze decomposition Fenton reaction generate damaging ROS hydroxyl radicals, causing damage lipids, proteins, DNA. Conversely, some metals, cadmium, suppress synthesis nitric oxide radical (NO · ), manifested by altered vasorelaxation and, consequently, blood pressure regulation. Pb-induced stress be indirectly responsible for depletion due its (O ·− resulting formation potent biological oxidant, peroxynitrite (ONOO − ). This review comprehensively discusses mechanisms effects. Aluminum (Al), (Cd), (As), mercury (Hg), (Pb), chromium (Cr) roles development gastrointestinal, pulmonary, kidney, reproductive, neurodegenerative (Alzheimer’s Parkinson’s diseases), cardiovascular, cancer (e.g. renal, lung, skin, stomach) diseases discussed. A short account devoted detoxification chelation use ethylenediaminetetraacetic acid ( EDTA), dimercaprol (BAL), 2,3-dimercaptosuccinic (DMSA), 2,3-dimercapto-1-propane sulfonic (DMPS), penicillamine chelators.

Language: Английский

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Porphyrin-based MOFs for photocatalysis in water: advancements in solar fuels generation and pollutants degradation

Inorganic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(8), P. 2212 - 2245

Published: Jan. 1, 2024

This review highlights the recent advances in photocatalytic applications of porphyrin-based MOFs aqueous environments for solar fuel generation and water remediation.

Language: Английский

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Heavy metals in biological samples of cancer patients: a systematic literature review

BioMetals, Journal Year: 2024, Volume and Issue: 37(4), P. 803 - 817

Published: Feb. 12, 2024

Abstract The majority of the so-called heavy metals are suspected to be involved in a number pathologies and play role human carcinogenesis. Some them (i.e. arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg) nickel (Ni)) have been defined as carcinogens, increasing susceptibility tumor development progression humans. Moreover, Ni, Cr, Cd, Hg, Pb together with zinc (Zn) iron (Fe), may capable stimulating breast cancer reducing patient’s sensitivity treatment through alterations DNA methylation. In patients gastric cancers, levels various augmented hypothesized amplify expression epidermal growth factor receptor type 2 gene. Cd increase risk lung negative impact on overall survival patients. To investigate relation between biological samples risk, occurrence individuals, comprehensive review work was performed, focus breast, lung, prostate cancers. An extensive search strategy devised ensure relevant literature could identified, PECO framework being adopted facilitate this identify key terms. As evidenced review, there is substantial data support hypothesis that influence progression. Unluckily papers dealing determination directly from tissues still rather limited, so we decided expand scope also analyses carried out other samples, urine, plasma, hair, nail, etc. studies reviewed showed several limitations current knowledge gaps present require further investigation improve our comprehension different tumorigenesis. Graphical abstract

Language: Английский

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Advanced omics approach and sustainable strategies for heavy metal microbial remediation in contaminated environments

Bioresource Technology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102040 - 102040

Published: Jan. 1, 2025

Language: Английский

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Transport and transformation of atmospheric metals in ecosystems: A review

Journal of Hazardous Materials Advances, Journal Year: 2022, Volume and Issue: 9, P. 100218 - 100218

Published: Dec. 20, 2022

Language: Английский

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A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: March 29, 2023

Toxicity with heavy metals has proven to be a significant hazard several health problems linked it. Heavy bioaccumulate in living organisms, pollute the food chain, and possibly threaten of animals. Many industries, fertilizers, traffic, automobile, paint, groundwater, animal feed are sources contamination metals. Few metals, such as aluminum (Al), may eliminated by elimination processes, but other like lead (Pb), arsenic (As), cadmium (Ca) accumulate body leading chronic toxicity Even if these have no biological purpose, their toxic effects still present some form that is damaging its appropriate functioning. Cadmium (Cd) Pb negative impacts on number physiological biochemical processes when exposed sub-lethal doses. The nephrotoxic Pb, As, Cd well known, high amounts naturally occurring environmental occupational populations exposures an adverse relationship between kidney damage metal exposure. Metal determined absorbed dosage, route exposure, duration whether acute or chronic. This can numerous disorders also result excessive due oxidative stress generated free radical production. concentration decreased through various procedures including bioremediation, pyrolysis, phytoremediation, rhizofiltration, biochar, thermal process. review discusses few mechanisms, cattle special emphasis kidneys.

Language: Английский

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Advanced Applications of Carbonaceous Materials in Sustainable Water Treatment, Energy Storage, and CO2 Capture: A Comprehensive Review

Sustainability, Journal Year: 2023, Volume and Issue: 15(11), P. 8815 - 8815

Published: May 30, 2023

The demand for energy has increased tremendously around the whole world due to rapid urbanization and booming industrialization. Energy is major key achieving an improved social life, but production utilization processes are main contributors environmental pollution greenhouse gas emissions. Mitigation of crisis reduction in (water air) difficulties leading research topics nowadays. Carbonaceous materials offer some best solutions minimize these problems easy effective way. It also advantageous that sources carbon-based economical, synthesis comfortable, applications environmentally friendly. Among carbonaceous materials, activated carbons, graphene, carbon nanotubes have shown outstanding performance mitigating pollution. These three exhibit unique adsorption properties storage, water purification, cleansing their electrical conductivity, large specific surface areas, strong mechanical strength. This paper reviews methods nanotubes, graphene significant treatment, dioxide capture improve sustainability.

Language: Английский

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