Community-level effects of ivermectin and moxidectin from cattle dung: zooplankton as study case DOI
Camila Jazmín Lorente, Daniel Nino Flores-Mendez, Leticia M. Mesa

et al.

Marine and Freshwater Research, Journal Year: 2024, Volume and Issue: 75(14)

Published: Sept. 23, 2024

Context Ivermectin (IVM) and moxidectin (MOX), are widely used internal external antiparasitic drugs for livestock. They enter into the aquatic environment because treated animals metabolise only a small percentage of administered doses, rest is eliminated through faeces posing risk to organisms. Aims This study aimed evaluate responses zooplankton environmentally relevant concentrations IVM MOX spiked in cattle dung short-term exposure. Methods We compared composition community, density, species richness, diversity total biomass between treatments with parasiticides controls. Key results The presence both altered community structure, leading shift composition. Cladocerans were most affected, drastic reduction their density. Additionally, decrease density copepods an increase rotifers observed treatments. Conclusions Both caused simplification as richness decreased. Overall, was more toxic than IVM. Implications Our suggest that long-term consequences on ecosystem services could arise, which merits development control livestock management tools protection these environments.

Language: Английский

Comparison of Antibiotic Use and the Frequency of Diseases Depending on the Size of Herd and the Type of Cattle Breeding DOI Creative Commons
Robert Kupczyński, Michał Bednarski,

Marcin Sokołowski

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(13), P. 1889 - 1889

Published: June 27, 2024

Diseases are responsible for losses in livestock production by increasing animal mortality and reducing productivity. The administration of antibiotics can help mitigate these negative effects. However, inappropriate use lead to severe complications, such as raising antibiotic resistance. purpose this study was perform a comparative analysis disease frequency over four years, based on the size dairy farms type farm. covered 4-year period included medium (20–50 cows, n = 13), large (>250 8), beef (n 8). collected data involved antimicrobial but also farm demographics, health, frequency, herd management practices. criteria used categorise into groups A–D were EMA guidelines. carried-out showed that cattle had highest consumption (18.29 mg·PCU−1), due high diseases, consequently, treatment calf (diarrhoea, lung inflammations) cow diseases (general mastitis). Cattle suffer mainly from general caused maintenance conditions. restrict was, some cases, unjustified (antibiotics dry therapy). Future studies should consider larger number farms, taking account given direction production.

Language: Английский

Citations

8
Anthelmintics in the environment: Their occurrence, fate, and toxicity to non-target organisms DOI
Ivan Vokřál, Radka Podlipná, Petra Matoušková

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 345, P. 140446 - 140446

Published: Oct. 16, 2023

Language: Английский

Citations

13
Examination of the effects of avermectin-induced anxiety-like behavior on growth in the Chinese mitten crab, Eriocheir sinensis DOI
Yi Huang, Qiang Huang, Shu Wu

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742276 - 742276

Published: Feb. 1, 2025

Language: Английский

Citations

0
Structural Optimization and Discovery of High Effectiveisopropanolamine-Based Tps1 Inhibitors as Promising Broad-Spectrum Fungicide Candidates DOI
Zhiyang Jiang, Na Wang,

Jinxiu Chen

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Pesticides and Allergens DOI

Shatabdi Ghose,

Bedanta Bhattacharjee, Damanbhalang Rynjah

et al.

Published: March 13, 2025

Citations

0
Structural Optimization and Discovery of High Effective Isopropanolamine-Based TPS1 Inhibitors as Promising Broad-Spectrum Fungicide Candidates DOI
Zhiyang Jiang, Na Wang,

Jinxiu Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 290, P. 117553 - 117553

Published: March 24, 2025

Language: Английский

Citations

0
Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use DOI Creative Commons
Clara Lima, Elisa Uliassi, Eli S.J. Thoré

et al.

Open Research Europe, Journal Year: 2024, Volume and Issue: 4, P. 207 - 207

Published: Sept. 23, 2024

Background The current scientific discourse on environmental impacts of veterinary medicines mostly focuses ectoparasiticides. Meanwhile, the widely prescribed drugs for treatment human and animal parasitic vector-borne diseases (PVBD) remain largely unexplored. There is thus a need evidence-based information to support guidelines protocols sustainable One Health PVBD drug development use, while promoting greener research practices. Here, we reflect potential in impact our practices developing new antiparasitics. Methods We conducted survey assess appreciation design concepts extent which sustainability principles are integrated into discovery development. also explored human, technical, funding resources currently used Europe neighbouring countries research. analysis reflection developed within “One against vector borne beyond” Cooperation Science Technology (COST) Action 21111 (OneHealthdrugs). Results response rate was 66%, from 32 countries, predominantly European. 87% participating collaborators worked Academia; groups were small (60% with 1-4 researchers) consist few researchers, at early career stages (63% <35 years old). Collaborations between academics, 60% collaborated non-European national governments. Motivation high but there as yet low implementation green strategies or incorporation ecotoxicological test workflows, due cost unfamiliarity. Conclusions highlight early-ecotoxicological testing candidates suggest best move towards standardized safe efficacious drugs.

Language: Английский

Citations

1
Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use DOI Creative Commons
Clara Lima, Elisa Uliassi, Eli S.J. Thoré

et al.

Open Research Europe, Journal Year: 2024, Volume and Issue: 4, P. 207 - 207

Published: Nov. 4, 2024

Background The current scientific discourse on environmental impacts of veterinary medicines mostly focuses ectoparasiticides. Meanwhile, the widely prescribed drugs for treatment human and animal parasitic vector-borne diseases (PVBD) remain largely unexplored. There is thus a need evidence-based information to support guidelines protocols sustainable One Health PVBD drug development use, while promoting greener research practices. Here, we reflect potential in impact our practices developing new antiparasitics. Methods We conducted survey membership “One against vector borne Europe beyond” Cooperation Science Technology (COST) Action 21111 (OneHealth drugs) assess appreciation design concepts extent which sustainability principles are integrated into discovery development. also explored human, technical, funding resources currently used neighbouring countries research. Results was analysed by OneHealth drugs garnered 89 respondents, representing response rate 66% from 32 countries, predominantly European. 87% participating collaborators worked Academia; groups were small (60% with 1–4 researchers) consist few researchers, at early career stages (63% <35 years old). Collaborations between academics, 60% collaborated non-European national governments. Motivation high but there as yet low implementation green strategies or incorporation ecotoxicological test workflows, due cost unfamiliarity. Conclusions highlight early-ecotoxicological testing candidates suggest best move towards standardized safe efficacious drugs.

Language: Английский

Citations

1
Community-level effects of ivermectin and moxidectin from cattle dung: zooplankton as study case DOI
Camila Jazmín Lorente, Daniel Nino Flores-Mendez, Leticia M. Mesa

et al.

Marine and Freshwater Research, Journal Year: 2024, Volume and Issue: 75(14)

Published: Sept. 23, 2024

Context Ivermectin (IVM) and moxidectin (MOX), are widely used internal external antiparasitic drugs for livestock. They enter into the aquatic environment because treated animals metabolise only a small percentage of administered doses, rest is eliminated through faeces posing risk to organisms. Aims This study aimed evaluate responses zooplankton environmentally relevant concentrations IVM MOX spiked in cattle dung short-term exposure. Methods We compared composition community, density, species richness, diversity total biomass between treatments with parasiticides controls. Key results The presence both altered community structure, leading shift composition. Cladocerans were most affected, drastic reduction their density. Additionally, decrease density copepods an increase rotifers observed treatments. Conclusions Both caused simplification as richness decreased. Overall, was more toxic than IVM. Implications Our suggest that long-term consequences on ecosystem services could arise, which merits development control livestock management tools protection these environments.

Language: Английский

Citations

0