bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 9, 2024
ABSTRACT
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
chemicals
with
widespread
industrial
consumer
applications,
firefighters
known
to
be
at
risk
of
elevated
PFAS
exposure
due
their
occupational
activities.
This
study
aims
assess
explore
potential
mechanistic
insights
through
miRNA
sequencing
plasma
exosomes,
in
relation
levels
the
general
population.
The
included
34
firefighter
participants.
were
analyzed,
exosomes
was
conducted.
findings
compared
population
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
While
total
did
not
significantly
differ
between
cohort
considered,
variations
individual
compounds
observed.
MiRNA
revealed
substantial
heterogeneity
expression
patterns.
Associations
serum
biochemical
indicators
suggested
health
implications,
although
further
need
explored.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
205, P. 107251 - 107251
Published: June 12, 2024
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
one
of
the
leading
causes
chronic
worldwide.
Epidemiological
studies
have
reported
that
exposure
population
to
environmental
endocrine-disrupting
chemicals
(EDCs)
associated
with
NAFLD.
However,
EDCs
are
different
types,
and
there
inconsistencies
in
relevant
evidence
descriptions,
which
not
been
systematically
summarized
so
far.
Therefore,
this
study
aimed
determine
association
between
Three
databases,
including
PubMed,
Web
science,
Embase
were
searched,
27
articles
included
study.
Methodological
quality,
heterogeneity,
publication
bias
assessed
using
Newcastle-Ottawa
scale,
I
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
264, P. 115473 - 115473
Published: Sept. 16, 2023
Etiology
of
hepatic
steatosis
and
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
among
acute
coronary
syndrome
(ACS)
remains
unclear.
Existing
studies
suggested
the
potential
role
per-
polyfluoroalkyl
substances
(PFAS)
in
comorbidity
ACS
patients.
Therefore,
we
conducted
a
cross-sectional
study
based
on
inpatients
to
assess
associations
plasma
PFAS
congeners
mixtures
with
MAFLD.
This
included
546
newly
diagnosed
Twelve
were
quantified
using
ultra-high-performance
liquid
chromatography-tandem
mass
spectrometry.
Hepatic
was
defined
by
index
(HSI).
MAFLD
as
combination
risk
factor
calculation
abnormalities.
Generalized
linear
model
used
examine
HSI
Adaptive
elastic
net
(AENET)
further
for
selection.
Mixture
effects
also
assessed
Bayesian
kernel
machine
regression
(BKMR).
Congeners
analysis
observed
significant
greater
percent
change
each
doubling
PFOS
(1.82%,
95%
CI:
0.87%,
2.77%),
PFHxS
(1.17%,
0.46%,
1.89%)
total
(1.84%,
0.56%,
3.14%).
Moreover,
(OR=1.42,
1.13,
1.81),
(OR=1.31,
1.09,
1.59)
(OR=1.43,
1.06,
1.94)
associated
increased
In
AENET
regression,
only
presented
positive
HSI.
indicated
between
is
first
demonstrate
patients,
which
provides
hypothesis
into
mechanisms
behind
well
tertiary
prevention
ACS.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: April 8, 2024
Background
Recent
research
showed
that
probiotics
treatment
may
reduce
insulin
resistance,
regulate
lipid
metabolism,
raise
liver
enzyme
levels,
and
ameliorate
inflammation
in
individuals
with
metabolic
associated
fatty
disease
(MAFLD).
However,
the
possible
effects
of
probiotic
use
on
progression
hepatic
steatosis
(HS)
have
not
been
identified.
The
purpose
this
study
was
to
investigate
a
large
population
database.
Methods
cross-sectional
conducted
among
adults
complete
data
yogurt
consumption
HS
2011–2016
National
Health
Nutrition
Examination
Survey
(NHANES).
Probiotic
assessed
using
dietary
supplement
questionnaire,
while
evaluated
index
(HSI).
To
explore
their
relationship,
weighted
univariate
regression
analysis,
subgroup
interaction
analysis
were
conducted.
evaluate
causal
association
between
NAFLD,
mendelian
randomization
(MR)
performed.
A
restricted
cubic
spline
(RCS)
used
analyze
relationship
curve
leves
steatosis.
Results
total
7,891
participants
included
represented
146.7
million
non-institutionalized
residents
United
States,
whom
4,322
(54.77%)
diagnosed
HS.
Multivariable
logistic
had
significantly
inverse
for
(OR
=
0.84,
95%
CI:
0.72–0.97,
p
0.02)
after
adjusting
all
covariates.
Once
more,
independent
verified
by
analysis.
MR
results
indicate
there
is
no
NAFLD.
RCS
model
demonstrated
robust
J-shaped
link
HS,
revealing
significant
decrease
risk
within
lower
range
consumption,
which
attained
lowest
close
0.4
cup.
Conclusion
According
NHANES
data,
has
beneficial
effect
whereas
indicated
it
related
indicates
account
inconsistency
results.
Based
these
findings,
we
recommend
take
half
cup
daily.
