Effects of voluntary and forced physical exercise on the retinal health of aging Wistar rats DOI Creative Commons

Anna Szilágyi,

Barbara Takács,

Réka Szekeres

et al.

GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 4707 - 4728

Published: May 25, 2024

Aging is accompanied by an increased prevalence of degenerative conditions, including those affecting ocular health, which significantly impact quality life and increase the burden on healthcare systems. Among these, retinal aging particular concern due to its direct link vision impairment, a leading cause disability in elderly. Vision loss population associated with heightened risks cognitive decline, social isolation, morbidity. This study addresses critical gap our understanding modifiable lifestyle factors, such as physical exercise, that may mitigate related pathologies. We investigated effects different exercise regimens-voluntary (recreational-type) forced (high-intensity)-on health Wistar rats (18-month-old), serving model for studying translational potential interventions humans. Male were divided into four groups: young control (3-month-old) baseline comparison, aged sedentary control, group engaging voluntary via running wheel their cage, subjected treadmill six sessions 20 min each per week. After 6-month experimental period, we assessed function electroretinography (ERG), measured thickness histologically, analyzed protein expression changes relevant oxidative stress, inflammation, anti-aging mechanisms. Our findings reveal positively impacts morphology, reducing stress inflammation markers while enhancing expression. In contrast, showed diminished benefits. These insights underscore importance intensity preference preserving during aging. The highlights recreational activity non-invasive strategy counteract aging, advocating further research regimens preventative therapies age-related degenerations.

Language: Английский

Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels DOI Open Access
Yue Ruan,

Subao Jiang,

Adrian Gericke

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(3), P. 1296 - 1296

Published: Jan. 28, 2021

Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress choroidal vascular dysfunction were suggested be critically involved In this review, we give an overview on the contributing pathophysiology of multifactorial discuss role reactive oxygen species function more detail. Moreover, therapeutic strategies for patients suffering from AMD.

Language: Английский

Citations

116
Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases DOI Creative Commons
Anna Ungvari, Rafał Gulej, Roland Patai

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

3
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health DOI Creative Commons
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Long COVID (also known as post-acute sequelae of SARS-CoV-2 infection [PASC] or post-COVID syndrome) is characterized by persistent symptoms that extend beyond the acute phase infection, affecting approximately 10% to over 30% those infected. It presents a significant clinical challenge, notably due pronounced neurocognitive such brain fog. The mechanisms underlying these effects are multifactorial, with mounting evidence pointing central role cerebromicrovascular dysfunction. This review investigates key pathophysiological contributing cerebrovascular dysfunction in long and their impacts on health. We discuss how endothelial tropism direct vascular trigger dysfunction, impaired neurovascular coupling, blood–brain barrier disruption, resulting compromised cerebral perfusion. Furthermore, appears induce mitochondrial enhancing oxidative stress inflammation within cells. Autoantibody formation following also potentially exacerbates injury, chronic ongoing compromise. These factors collectively contribute emergence white matter hyperintensities, promote amyloid pathology, may accelerate neurodegenerative processes, including Alzheimer’s disease. emphasizes critical advanced imaging techniques assessing health need for targeted interventions address complications. A deeper understanding essential advance treatments mitigate its long-term consequences.

Language: Английский

Citations

3
The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration DOI Creative Commons
Annamaria Tisi, Marco Feligioni, M. Passacantando

et al.

Cells, Journal Year: 2021, Volume and Issue: 10(1), P. 64 - 64

Published: Jan. 4, 2021

The blood retinal barrier (BRB) is a fundamental eye component, whose function to select the flow of molecules from retina and vice-versa, its integrity allows maintenance finely regulated microenvironment. outer BRB, composed by choriocapillaris, Bruch’s membrane, pigment epithelium, undergoes structural functional changes in age-related macular degeneration (AMD), leading cause blindness worldwide. BRB alterations lead dysfunction neurodegeneration. Several risk factors have been associated with AMD onset past decades oxidative stress widely recognized as key factor, even if exact pathophysiology has not exactly elucidated yet. present review describes physiology, occurring AMD, role focus on structures. Moreover, we propose use cerium oxide nanoparticles new powerful anti-oxidant agent combat based relevant existing data which demonstrated their beneficial effects protecting animal models AMD.

Language: Английский

Citations

103
Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond DOI Open Access
Elżbieta Pawłowska, Joanna Szczepańska, Ali Koskela

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 13

Published: March 24, 2019

Age-related macular degeneration (AMD) is a multifactorial disease of the retina featured by and loss photoreceptors retinal pigment epithelium (RPE) cells with oxidative stress playing role in its pathology. Although systematic reviews do not support protective diet rich antioxidants against AMD, dietary polyphenols (DPs) have been reported to beneficial effects on vision. Some them, such as quercetin cyanidin-3-glucoside, can directly scavenge reactive oxygen species (ROS) due presence two hydroxyl groups their B ring structure. Apart from direct ROS scavenging, DPs lower several other pathways. Many induce NRF2 (nuclear factor, erythroid 2-like 2) activation expression phase II enzymes that are under transcriptional control this factor. inhibit A2E photooxidation RPE cells, which source stress. Anti-inflammatory action associated regulation various interleukins signaling pathways, including IL-6/JAK2 (Janus kinase 2)/STAT3. improve impaired cellular waste clearance, AMD-specific deficient phagocytosis A β 42 peptide autophagy.

Language: Английский

Citations

91
Recent Advances in Age-Related Macular Degeneration Therapies DOI Creative Commons
Marie Fabre,

Lou Mateo,

Diana Lamaa

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5089 - 5089

Published: Aug. 10, 2022

Age-related macular degeneration (AMD) was described for the first time in 1840s and is currently leading cause of blindness patients over 65 years Western Countries. This disease impacts eye's posterior segment damages macula, a retina section with high levels photoreceptor cells responsible central vision. Advanced AMD stages are divided into atrophic (dry) form exudative (wet) form. Atrophic consists progressive atrophy retinal pigment epithelium (RPE) outer layers, while results anarchic invasion by choroidal neo-vessels RPE retina. fluid accumulation intra/sub-retinal spaces dysfunction cells. To date, few existing anti-AMD therapies may only delay or suspend its progression, without providing cure to patients. However, last decade, an outstanding number research programs targeting different aspects have been initiated academics industrials. review aims bring together most recent advances insights mechanisms underlying pathogenicity evolution, highlight current hypotheses towards development new treatments, i.e., symptomatic vs. curative. The therapeutic options drugs proposed tackle these analyzed critically compared. A particular emphasis has given agents tested clinical trials, whose carefully collected discussed whenever possible.

Language: Английский

Citations

59
Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension DOI Creative Commons
Jacqueline Chua, Calvin Chin, Bingyao Tan

et al.

Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)

Published: April 9, 2019

Abstract We investigated the characteristics of choriocapillaris flow voids using optical coherence tomography angiography (OCTA) in 85 patients (164 eyes) with hypertension (mean ± SD age, 56 11 years; 45% women; 20% poorly controlled BP; 16% diabetes) who are without ocular diseases and determined possible correlations systemic vascular risk factors. Data on 24-hour ambulatory blood pressure (BP), serum creatinine, urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based CKD-EPI Creatinine Equation. OCTA imaging (6 × 6 mm scans; AngioVue) quantitative microvascular analysis performed. Linear regression used to investigate association factors area (percentage), size (pixels) number voids. Diabetes (β = 0.33; 95% CI, 0.02 0.63) daytime systolic BP −0.13; −0.24 −0.02) associated areas Age 0.21; 0.06 0.36) diastolic −0.18; −0.34 −21.21; −31.79 −10.63) nighttime 13.89; 0.61 27.17) Kidney parameters not any features In hypertension, a higher appeared increase which needs be considered when study eye hypertensives.

Language: Английский

Citations

60
Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration DOI

Jae‐Byoung Chae,

Hyoik Jang,

Chanok Son

et al.

GeroScience, Journal Year: 2021, Volume and Issue: 43(6), P. 2809 - 2833

Published: Oct. 2, 2021

Language: Английский

Citations

43
Sex Differences in Cardiovascular Aging and Heart Failure DOI
Andrew P. Oneglia, Michael D. Nelson, C. Noel Bairey Merz

et al.

Current Heart Failure Reports, Journal Year: 2020, Volume and Issue: 17(6), P. 409 - 423

Published: Sept. 28, 2020

Language: Английский

Citations

50
Oxidative stress and epigenetics in ocular vascular aging: an updated review DOI Creative Commons
Bowen Zhao,

Lijia Zhu,

Meng Ye

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: Feb. 27, 2023

Abstract Vascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascular and microvascular diseases. Diabetic retinopathy (DR) age-related macular degeneration (AMD), characterized by dysfunction, are common causes irreversible blindness worldwide, however there still lack effective therapeutic strategies for rescuing visual function. In order to develop novel treatments, it essential illuminate pathological mechanisms underlying vascular during DR AMD progression. this review, we have summarized recent discoveries effects oxidative stress epigenetics on degeneration, could provide potential targets AMD.

Language: Английский

Citations

14