Gut-Brain Axis to Investigate the Effects of Gut Health on Cognitive Functioning in Adults DOI Open Access
Muddsar Hameed, Fatima Noor,

Hamza Hussain

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Introduction: The gut-brain axis is a bidirectional communication network linking the gastrointestinal tract and central nervous system via neuronal, hormonal, antibody signaling pathways. Central to this connection gut health, encompassing balance functionality of microbiota, which significantly impacts on mental cognitive health. This study investigates association between health functioning in adults, highlighting mechanisms by microbiota influence brain Objective: To examine effects adult performance, with focus processes Methods: A quantitative cross-sectional was conducted Islamabad from January 2024 April 2024, involving 140 participants. Data were collected using comprehensive 16-item questionnaire cognition self-assessment rating scale (C-SARS). psychometric properties these scales assessed, data analyzed Statistical Product Service Solutions (SPSS, v26; IBM SPSS Statistics for Windows, Armonk, NY). Analytical descriptive statistics, including regression, chi-square, independent sample t-tests, mean standard deviation, applied. Results: found moderate associations particularly memory processing speed (R² = 0.17, β -1.9, p 0.12 general cognition; R² 0.01, -0.98, 0.02 memory; 0.03, -0.18, 0.03 speed). Gender marital status differences significant, males exhibiting better scores than females (M 34.1, SD 3.2 vs. M 31.2, 3.2, 0.00), singles showing performance compared married individuals 9.4, 5.4 6.5, 3.7, 0.03). Conclusion: highlights significant functions, suggesting that composition can performance. underscore need consider individual research. Future studies should replicate findings larger samples explore microbiota-targeted interventions enhancement.

Language: Английский

A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

9
The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis DOI Creative Commons
Mónika Fekete, Péter Varga, Zoltán Ungvári

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk decline dementia. To investigate protective effects diet on we conducted systematic literature review using PubMed, Web Science, Google Scholar, focusing studies published between 2000 2024. included in meta-nalysis examined adherence to incidence AD. We applied random-effects model calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs) assessed heterogeneity through I -square statistics. Forest plots, funnel Z -score plots were used visualize study outcomes. Of 324 full-text records reviewed, 23 met inclusion criteria. combined HR among those adhering was 0.82 (95% CI 0.75–0.89); 0.89 0.83–0.95); AD, 0.70 0.60–0.82), indicating substantial effects. Significant observed across studies, though suggested sufficient sample sizes support reliable conclusions each condition. In conclusion, this meta-analysis confirms that is associated an 11–30% reduction age-related disorders, including impairment, These findings underscore diet’s potential central element neuroprotective public health strategies mitigate promote healthier aging.

Language: Английский

Citations

7
Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases DOI Creative Commons
Anna Ungvari, Rafał Gulej, Roland Patai

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

3
Exploring the global impact of obesity and diet on dementia burden: the role of national policies and sex differences DOI

Xueshan Cao,

Han-Guang Peng,

Ziyi Hu

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Language: Английский

Citations

17
Greater Symptom Burden and Poorer Quality of Life Outcomes Are Associated With The Co-Occurrence of Anxiety and Depression During Cancer Chemotherapy DOI Creative Commons

Alejandra Calvo‐Schimmel,

Marilyn J. Hammer, Yvette P. Conley

et al.

Seminars in Oncology Nursing, Journal Year: 2025, Volume and Issue: unknown, P. 151809 - 151809

Published: Feb. 1, 2025

Anxiety and depression are common symptoms in oncology patients undergoing chemotherapy. Study purpose was to evaluate for differences severity of (ie, fatigue, energy, sleep disturbance, cognitive function, pain) quality life (QOL) outcomes among three subgroups outpatients with distinct joint anxiety profiles. Oncology (N = 1328) completed measures state depression, six times over two cycles Latent profile analysis done identify AND Patients trait anxiety, morning evening pain, as well generic disease-specific QOL at enrollment. Differences the classes symptom scores were evaluated using parametric non-parametric tests. Three profiles identified named: Low Depression (57.5%, Both Low), Moderate (33.7%, Moderate), High (8.8%, High). All showed a "dose-response effect" worsened, all increased). Likewise, both general (except spiritual well-being) measures, decreased worsened. Compared classes, other reported lower well-being domain. More than 40% receiving chemotherapy experience moderate high levels depression. These report an extremely burden significant decrements domains QOL. Clinicians need perform comprehensive assessments during In addition, referrals targeted interventions needed manage multiple improve patients'

Language: Английский

Citations

1
The Oral–Gut Microbiome–Brain Axis in Cognition DOI Creative Commons

Noorul Ain Adil,

Christabel Omo-erigbe,

Hariom Yadav

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 814 - 814

Published: April 3, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss, affecting millions worldwide. Emerging evidence highlights the oral microbiome—a complex ecosystem of bacteria, fungi, viruses, protozoa as significant factor in health. Dysbiosis microbiome contributes to systemic inflammation, disrupts blood–brain barrier, promotes neuroinflammation, processes increasingly implicated pathogenesis AD. This review examines mechanisms linking dysbiosis through oral–brain oral–gut–brain axis. These interconnected pathways enable bidirectional communication between cavity, gut, brain via neural, immune, endocrine signaling. Oral pathogens, such Porphyromonas gingivalis, along with virulence factors, including lipopolysaccharides (LPS) gingipains, contribute while metabolic byproducts, short-chain fatty acids (SCFAs) peptidoglycans, further exacerbate immune activation. Additionally, this explores influence external diet, pH balance, medication use, smoking, alcohol consumption, hygiene, on microbial diversity stability, highlighting their role shaping outcomes. The dynamic interplay gut microbiomes reinforces importance homeostasis preserving neurological interventions, probiotics, prebiotics, dietary modifications, offer promising strategies support function reduce risk diseases, AD, maintaining diverse microbiome. Future longitudinal research needed identify long-term impact cognition.

Language: Английский

Citations

1
Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study DOI Creative Commons
Riko Mishima, Ryuta Ejima, Satoshi Arai

et al.

Gut Microbes Reports, Journal Year: 2025, Volume and Issue: 2(1)

Published: April 10, 2025

Language: Английский

Citations

1
Multi-omics insights into anti-colitis benefits of the synbiotic and postbiotic derived from wheat bran arabinoxylan and Limosilactobacillus reuteri DOI

Lanqi Zhou,

Song Wei, Tianqi Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134860 - 134860

Published: Aug. 18, 2024

Language: Английский

Citations

4
The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function DOI Creative Commons

Gulshara Abildinova,

Valeriy Benberin, Tamara Vochshenkova

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 26, 2024

The gut-brain-metabolic axis has emerged as a critical area of research, highlighting the intricate connections between gut microbiome, metabolic processes, and cognitive function. This review article delves into complex interplay these interconnected systems, exploring their role in development insulin resistance decline. emphasizes pivotal influence microbiota on central nervous system (CNS) function, demonstrating how microbial colonization can program hypothalamic-pituitary-adrenal (HPA) for stress response mice. It further elucidates mechanisms by which carbohydrate metabolism contributes to resistance, key factor pathogenesis disorders impairment. Notably, highlights therapeutic potential targeting through various interventions, such dietary modifications, probiotics, prebiotics, fecal transplantation (FMT). These approaches have shown promising results improving sensitivity function both animal models human studies. also need research elucidate specific species metabolites involved modulating gut-brain axis, well long-term effects safety interventions. Advances metagenomics, metabolomics, bioinformatics are expected provide deeper insights interactions within impact host health. Overall, this comprehensive underscores significance treatment disorders, offering avenue novel strategies system.

Language: Английский

Citations

4
Chitosan lactate improves repeated closed head injury-generated motor and neurological dysfunctions in mice by impacting microbiota gut-brain axis DOI
Mohd Rabi Bazaz,

Hara Prasad Padhy,

Manoj P. Dandekar

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 3, 2025

Language: Английский

Citations

0