Life Sciences, Journal Year: 2024, Volume and Issue: 359, P. 123202 - 123202
Published: Nov. 1, 2024
Language: Английский
GeroScience, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский
Citations
3
GeroScience, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract Long COVID (also known as post-acute sequelae of SARS-CoV-2 infection [PASC] or post-COVID syndrome) is characterized by persistent symptoms that extend beyond the acute phase infection, affecting approximately 10% to over 30% those infected. It presents a significant clinical challenge, notably due pronounced neurocognitive such brain fog. The mechanisms underlying these effects are multifactorial, with mounting evidence pointing central role cerebromicrovascular dysfunction. This review investigates key pathophysiological contributing cerebrovascular dysfunction in long and their impacts on health. We discuss how endothelial tropism direct vascular trigger dysfunction, impaired neurovascular coupling, blood–brain barrier disruption, resulting compromised cerebral perfusion. Furthermore, appears induce mitochondrial enhancing oxidative stress inflammation within cells. Autoantibody formation following also potentially exacerbates injury, chronic ongoing compromise. These factors collectively contribute emergence white matter hyperintensities, promote amyloid pathology, may accelerate neurodegenerative processes, including Alzheimer’s disease. emphasizes critical advanced imaging techniques assessing health need for targeted interventions address complications. A deeper understanding essential advance treatments mitigate its long-term consequences.
Language: Английский
Citations
2
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0317915 - e0317915
Published: Feb. 18, 2025
Background Since its emergence in 2019, COVID-19 has become a global epidemic. Several studies have suggested link between Alzheimer’s disease (AD) and COVID-19. However, there is little research into the mechanisms underlying these phenomena. Therefore, we conducted this study to identify key genes associated with AD, evaluate their correlation immune cells characteristics metabolic pathways. Methods Transcriptome analyses were used common biomolecular markers of AD Differential expression analysis weighted gene co-expression network (WGCNA) performed on chip datasets (GSE213313, GSE5281, GSE63060) from patients both conditions. Gene ontology (GO) enrichment identified molecular mechanisms. The core using machine learning. Subsequently, evaluated relationship Finally, our findings validated through single-cell analysis. Results 484 differentially expressed (DEGs) by taking intersection black module, containing 132 genes, showed highest association two diseases according WGCNA. GO revealed that mainly affect inflammation, cytokines, immune-related functions, signaling pathways related metal ions. Additionally, learning approach eight genes. We links also found EIF3H oxidative phosphorylation. Conclusion This identifies shared pathways, alterations, changes potentially contributing pathogenesis AD.
Language: Английский
Citations
1
Infectious Disease Clinics of North America, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
1
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102400 - 102400
Published: June 28, 2024
Language: Английский
Citations
4
GeroScience, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 13, 2024
The aging population in Europe faces a substantial burden from dementia, with vascular cognitive impairment and dementia (VCID) being preventable cause. Atrial fibrillation (AF), common cardiac arrhythmia, increases the risk of VCID through mechanisms such as thromboembolism, cerebral hypoperfusion, inflammation. This review explores epidemiology, pathophysiology, preventive strategies for AF-related VCID. Epidemiological data indicate that AF prevalence rises age, affecting up to 12% individuals over 80. Neuroimaging studies reveal chronic brain changes patients, including strokes, lacunar white matter hyperintensities (WMHs), microbleeds (CMHs), while assessments show impairments memory, executive function, attention. COVID-19 pandemic has exacerbated underdiagnosis AF, leading an increase undiagnosed strokes impairment. Many elderly did not seek medical care due fear exposure, resulting delayed diagnoses. Additionally, reduced family supervision during contributed missed opportunities early detection related complications. Emerging evidence suggests long COVID may also elevate further complicating management this condition. underscores importance comprehensive mitigate decline. Preventive measures, public awareness campaigns, patient education, use smart devices detection, are crucial. Anticoagulation therapy, rate rhythm control, addressing comorbid conditions essential therapeutic strategies. Recognizing cardiovascular impacts especially context pandemic, is advancing health.
Language: Английский
Citations
4
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome (CFS), is a complex, condition marked by persistent, debilitating that not alleviated rest and often worsens with physical or mental exertion. Along fatigue, patients experience various symptoms, including cognitive impairments, post-exertional malaise, muscle joint pain, sleep disturbances, immune system dysfunction. Diagnosing CFS/ME challenging due to the absence of definitive biomarkers, overlap symptoms other conditions, lack standardized diagnostic criteria. This comprehensive literature review aims contribute understanding CFS/ME, its diagnosis, pathophysiology, differential treatment, future directions.
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 8, 2025
Sepsis is a severe and life-threatening medical syndrome that can lead to organ failure death. Despite advances in treatment, current therapies are often inadequate, with high septic mortality rates. Therefore, there critical need for reliable prognostic markers be used clinical settings improve the management outcomes of patients sepsis. Recent studies have suggested mitochondrial dynamics, including processes fission fusion, closely related severity sepsis status inflammation. By monitoring transcriptomic signals new biomarkers engineered more accurately predict survival risk. Such would invaluable settings, aiding healthcare providers early identification high-risk improving treatment strategies. To achieve this goal, we utilized major regulatory protein dynamin-related 1 (Drp1, gene code DNM1L) identified Drp1-associated genes enriched genes. A 12-gene signature (GS) was established as differentially expressed (DEG)-based GS. Next, compared proteins interact Drp1 7 common genes, establishing GS term protein-protein interaction (PPI)-based evaluate if these GSs survival, publicly available human blood datasets from patients. We confirmed both successfully discovery validation cohorts sensitivity specificity, PPI-based showing enhanced performance. Together, study engineers validated blood-borne biomarker (PPI-based 7-gene GS) risk prediction. This holds potential optimizing personalized strategies reduce mortality.
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107670 - 107670
Published: Feb. 20, 2025
Sirtuin 1 (SIRT1), a NAD+ -dependent histone deacetylase, plays crucial role in mitigating oxidative stress, regulating inflammation, and maintaining mitochondrial function. Reduced SIRT1 activity has been linked to elevated pro-inflammatory cytokines, dysfunction, chronic pain, all of which are observed long COVID pathology. Emerging evidence identifies dysfunction stress as central contributors these symptoms. Increases reactive oxygen species (ROS) such superoxide, nitric oxide, peroxynitrite, leading damage, central/peripheral sensitization. Nutraceuticals, particularly the polyphenolic fraction bergamot (BPF), have demonstrated potent antioxidant, anti-inflammatory, antiviral properties. This study highlights BPF's ability modulate rat model inflammation hyperalgesia. It provides novel nitration within nucleus key event inflammatory pain pathogenesis. BPF administration preserved activity, reduced markers malondialdehyde (MDA) 8-hydroxydeoxyguanosine (8-OHdG), minimized post-translational modifications nuclear proteins, including nitration, acetylation, carbonylation. Additionally, it alleviated hyperalgesia allodynia. These findings underscore therapeutic potential polyphenols like reducing inflammation-driven pain. By activating SIRT1, may provide relief for conditions. Further research on SIRT1-targeted therapies is essential combat preventing conditions enhancing treatment options.
Language: Английский
Citations
0
Current Research in Biotechnology, Journal Year: 2025, Volume and Issue: 9, P. 100280 - 100280
Published: Jan. 1, 2025
Language: Английский
Citations
0