Nanozyme‐Based Regulation of Cellular Metabolism and Their Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: April 5, 2023

Metabolism is the sum of enzyme-dependent chemical reactions, which produces energy in catabolic process and synthesizes biomass anabolic process, exhibiting high similarity mammalian cell, microbial plant cell. Consequently, loss or gain metabolic enzyme activity greatly affects cellular metabolism. Nanozymes, as emerging mimics with diverse functions adjustable catalytic activities, have shown attractive potential for regulation. Although basic tasks are highly similar cells from different species, concrete pathway varies intracellular structure species. Here, metabolism living organisms described similarities differences pathways among mammalian, microbial, regulation mechanism discussed. The recent progress on mainly including nutrient uptake utilization, production, accompanied redox reactions by kinds oxidoreductases their applications field disease therapy, antimicrobial sustainable agriculture systematically reviewed. Furthermore, prospects challenges nanozymes regulating cell also discussed, broaden application scenarios.

Language: Английский

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Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(9), P. 3577 - 3599

Published: Aug. 17, 2023

Nanozymes are nanoparticles with intrinsic enzyme-mimicking properties that have become more prevalent because of their ability to outperform conventional enzymes by overcoming drawbacks related stability, cost, and storage. the potential manipulate active sites natural enzymes, which is why they considered promising candidates function as enzyme mimetics. Several microscopy- spectroscopy-based techniques been used for characterization nanozymes. To date, a wide range nanozymes, including catalase, oxidase, peroxidase, superoxide dismutase, designed effectively mimic enzymes. The activity nanozymes can be controlled regulating structural morphological aspects multifaceted benefits, exploited on large scale application in biomedical sector. versatility aids monitoring treating cancer, other neurodegenerative diseases, metabolic disorders. Due compelling advantages significant research advancements made this area. Although act potent mimetics specificities suboptimal, there still room diversification analytical purposes. Designing diverse nanozyme systems sensitive one or substrates through specialized has subject an in-depth study. Hence, we believe stimuli-responsive may open avenues diagnosis treatment fusing catalytic nanomaterial systems.

Language: Английский

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Enzyme-mimetic antioxidant nanomaterials for ROS scavenging: Design, classification, and biological applications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 500, P. 215536 - 215536

Published: Nov. 4, 2023

Language: Английский

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Modulating the Coordination Environment of Carbon‐Dot‐Supported Fe Single‐Atom Nanozymes for Enhanced Tumor Therapy

Small, Journal Year: 2023, Volume and Issue: 20(8)

Published: Oct. 10, 2023

Abstract Herein, carbon dot (CD)‐supported Fe single‐atom nanozymes with high content of pyrrolic N and ultrasmall size (ph‐CDs‐Fe SAzyme) are fabricated by a phenanthroline‐mediated ligand‐assisted strategy. Compared phenanthroline‐free (CDs‐Fe SAzyme), ph‐CDs‐Fe SAzyme exhibit higher peroxidase (POD)‐like activity due to their structure similar that ferriporphyrin in natural POD. Aberration‐corrected high‐angle annular dark field scanning transmission electron microscopy (HAADF‐STEM) X‐ray absorption fine spectroscopy (XAFS) analyses show metal is dispersed as single atoms. Steady‐state kinetic studies the maximum velocity ( V max ) turnover number k cat H 2 O homolytic cleavage catalyzed 3.0 6.2 more than those reaction CDs‐Fe SAzyme. Density functional theory (DFT) calculations energy barrier lower Antitumor efficacy experiments can efficiently inhibit growth tumor cells both vitro vivo synergistic chemodynamic photothermal effects. Here new paradigm provided for development efficient antitumor therapeutic approaches based on POD‐like activity.

Language: Английский

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Nanozyme-reinforced hydrogel coatings for prevention of catheter-associated urinary tract infection

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102271 - 102271

Published: April 21, 2024

Language: Английский

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Defect-rich RuO2/IrO2 heterojunction with dual enzyme-mimic activities for boosting biocatalytic disinfection

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 481, P. 148888 - 148888

Published: Jan. 23, 2024

Language: Английский

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Copper-crosslinked carbon dot hydrogel nanozyme for colorimetric - tert-butylhydroquinone biosensing and smartphone-assisted visual ratiometric assay

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 468, P. 133795 - 133795

Published: Feb. 15, 2024

Language: Английский

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Nanozymes with biomimetically designed properties for cancer treatment

Nanoscale, Journal Year: 2024, Volume and Issue: 16(16), P. 7786 - 7824

Published: Jan. 1, 2024

The therapeutic efficacy of nanozymes, which have wide applications in cancer treatment, can be enhanced by various biomimetic design strategies, from structural and process mimicry to advanced functional biomimicry.

Language: Английский

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Advances in bimetallic materials and bimetallic oxide nanozymes: Synthesis, classification, catalytic mechanism and application in analytical chemistry

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 176, P. 117757 - 117757

Published: May 13, 2024

Language: Английский

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Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 20, 2025

Abstract Reconstructing large, inflammatory maxillofacial defects using stem cell-based therapy faces challenges from adverse microenvironments, including high levels of reactive oxygen species (ROS), inadequate oxygen, and intensive inflammation. Here, inspired by the reaction mechanisms intracellular antioxidant defense systems, we propose de novo design an artificial antioxidase Ru-doped layered double hydroxide (Ru-hydroxide) for efficient redox homeostasis bone regeneration. Our studies demonstrate that Ru-hydroxide consists hydroxyls-synergistic monoatomic Ru centers, which efficiently react with collaborate hydroxyls rapid proton electron transfer, thus exhibiting efficient, broad-spectrum, robust ROS scavenging performance. Moreover, can effectively sustain cell viability osteogenic differentiation in elevated environments, modulating microenvironment during tissue regeneration male mice. We believe this development offers a promising avenue designing antioxidase-like materials to treat various inflammation-associated disorders, arthritis, diabetic wounds, enteritis, fractures.

Language: Английский

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