Electrochemical oxidative heterodifunctionalization of dehydroalanine: access to unnatural α,α-disubstituted amino esters DOI
Hui Cao, Ruitao Wang,

Qianqiu Zhang

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(9), P. 2566 - 2571

Published: Jan. 1, 2024

A general, efficient, and mild Dha electrochemical modification strategy is reported, which enables a divergent route to various α,α-disubstituted amino esters via anodic cascade oxidation nucleophilic attack.

Language: Английский

Direct electrochemical synthesis of arenesulfonyl fluorides from nitroarenes: a dramatic ionic liquid effect DOI
Xianqiang Kong, Qianwen Liu, Yiyi Chen

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(6), P. 3435 - 3440

Published: Jan. 1, 2024

A practical electrosynthesis of aryl sulfonyl fluorides from nitroarenes is described. Cheap N -methylimidazolium p -toluenesulfonate has been found to be an effective additive, promoting the desired fluorosulfonylation under very mild conditions.

Language: Английский

Citations

26
Paired Electrolysis Enabled Trifluoromethylheteroaromatization of Alkenes and Alkyne with Trifluoromethyl Thianthrenium Triflate (TT-CF3+OTf–) as a Bifunctional Reagent DOI
Xiang Fang,

Dehui Wang,

Kun Xu

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 26(1), P. 411 - 415

Published: Dec. 26, 2023

We report a strategic exploitation of trifluoromethyl thianthrenium triflate (TT-CF3+OTf–) as both electromediator and CF3 radical precursors for paired electrolysis. Enabled by this strategy, the three-component trifluoromethylheteroaromatization alkenes alkynes was realized. The superiority TT-CF3+OTf– to other electrophilic reagents is attributed cathodic generation thianthrene (TT) mediator, which shifts heterogeneous oxidation interest homogeneous one.

Language: Английский

Citations

26
Electrochemical Multicomponent Cascade Radical Process Enabling Synthesis of Iodomethyl Spiropyrrolidinyl‐Oxindoles DOI

Jingrui He,

Haibo Mei, Jorge Escorihuela

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(15), P. 1691 - 1698

Published: March 19, 2024

Comprehensive Summary A novel electrochemical multicomponent cascade reaction of indole‐tethered alkenes with CF 3 SO 2 Na and n ‐Bu 4 NI has been developed, which enables the rapid assembly spiropyrrolidinyl‐oxindoles in good yields. The experimental results DFT calculations suggest that this proceeds through oxidation Na, radical coupling alkene, spirocyclization, sulfinate, iodide substitution, water coupling. This strategy features mild conditions, easy‐to‐handle reactants, chemical finding not only enriches research contents but also provides a green for construction compared existing methodologies.

Language: Английский

Citations

9
Electro-reductive carboxylation of C Cl bonds in unactivated alkyl chlorides and polyvinyl chloride with CO2 DOI
Li Li, Zhi-xin Yan,

Chuan‐Kun Ran

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(12), P. 110104 - 110104

Published: June 8, 2024

Language: Английский

Citations

9
Direct Amino-α-C–H Heteroarylation of Amides under Electrochemical Conditions DOI

Congcong Qiang,

Tan Zhang,

Zhaoyue Feng

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(2), P. 493 - 497

Published: Jan. 8, 2024

An electrochemical hydrogen atom transfer (HAT) strategy for the direct amino-α-C–H heteroarylation of amides is described. The cheap TMSN3 acts as a reagent. A series heteroarenes including quinoxalin-2(1H)-ones, 4-methylquinoline, isoquinoline, 2-methylquinoxaline, benzothiazole, etc., and various readily available amides/lactams were suitable. reaction has characteristics wide range substrates, good regioselectivity, chemical oxidant-free conditions, etc.

Language: Английский

Citations

8
Recent Advances on C—H Functionalization via Oxidative Electrophotocatalysis DOI

Aman Hasil,

Rui Chang,

Juntao Ye

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(3), P. 728 - 728

Published: Jan. 1, 2024

Language: Английский

Citations

8
Electrochemical conversion of organic compounds and inorganic small molecules DOI

Wei-Mei Zeng,

Youai Qiu

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 3223 - 3246

Published: July 9, 2024

Language: Английский

Citations

8
Organo-electroreduction enables arylcarboxylation of styrenes DOI
Yanwei Wang, Qian Wang, Zile Zhu

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

Citations

7
Electrochemical Difunctionalization of Alkenes DOI Open Access

Yin Zhang,

Zilong Zhou,

Jin‐Heng Li

et al.

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Owing to their wide utilizations in synthesis and products prevalence numerous natural products, pharmaceuticals functional materials, the alkene difunctionalization methods for selective transformations of olefins are important have attracted much attention form synthetic chemists. Among them, electrochemical reaction is particularly promising has becoming a potent sustainable tool alkenes into vicinal difunctionalized structures organic through simultaneous incorporation two groups. Herein, we summarize recent progress reactions according types as well category radicals over past five years. By selecting remarkable examples, elaborately discussed substrate scope mechanisms olefin reaction.

Language: Английский

Citations

1
Electrochemical remote C(sp3)–H thiocyanation DOI

Xin‐Yu Pang,

Hui He, Xiangrui Meng

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(8), P. 2283 - 2288

Published: Jan. 1, 2024

An electrochemical thiocyanation of distal C(sp 3 )–H bonds based on amidyl radical-mediated 1,5-HAT has been developed. The transformation is highly site-selective and compatible with primary, secondary, tertiary sulfonamides, bioactive derivatives.

Language: Английский

Citations

5