Photobiocatalytic Platform for the Efficient Enantio-Divergent Synthesis of β-Fluoromethylated Ketones DOI
Yuan‐Yang Guo,

Ze‐Hua Tian,

Linghong Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(45), P. 31012 - 31020

Published: Oct. 30, 2024

β-Fluoromethyl (CH

Language: Английский

Sulfinate-Promoted Defluorinative Cyclization of Polyfluoroalkyl Tetralones Enabled by Photocatalysis DOI

Ming-Yao Tang,

M Kellis, Xiaoxiao Sun

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

A Ru-catalyzed defluorinative cyclization of polyfluoroalkyl tetralones has been developed under visible-light irradiation for the precise assembly γ-pyrones featuring α-perfluoroalkyl and β-fluorine substituents. Selective functionalization five C(sp3)–F bonds at three carbon sites on perfluoroalkyl chain provides a new mode utilizing polyfluorides as versatile synthons to access difficult-to-obtain heterocyclic scaffolds. Moreover, sulfinate salt serves dual roles an oxygen source creating carbonyl group defluorinating promoter.

Language: Английский

Citations

3
Multi-functionalization of β-trifluoromethyl enones enabled 2,3-dihydrofuran synthesis DOI

Ya-Fei Hu,

Wei Han,

Ye-Kun Chen

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(18), P. 5144 - 5150

Published: Jan. 1, 2024

A transition-metal-free multi-functionalization reaction of β-trifluoromethyl enones and azacycles is first developed for the synthesis valuable amino-2,3-dihydrofuran derivatives.

Language: Английский

Citations

4
Photobiocatalytic Platform for the Efficient Enantio-Divergent Synthesis of β-Fluoromethylated Ketones DOI
Yuan‐Yang Guo,

Ze‐Hua Tian,

Linghong Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(45), P. 31012 - 31020

Published: Oct. 30, 2024

β-Fluoromethyl (CH

Language: Английский

Citations

1