Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

Neurobiology of Disease, Journal Year: 2019, Volume and Issue: 134, P. 104621 - 104621

Published: Oct. 16, 2019

The last decade has witnessed an exponentially growing interest in gut microbiota and the gut-brain axis health disease. Accumulating evidence from preclinical clinical research indicate that microbiota, their associated microbiomes, may influence pathogenic processes thus onset progression of various diseases, including neurological psychiatric disorders. In fact, dysbiosis (microbiota dysregulation) been with a range neurodegenerative Alzheimer's, Parkinson's, Huntington's motor neuron disease, as well multiple sclerosis. constitutes dynamic microbial system constantly challenged by many biological variables, environmental factors. Since constitute changeable experience-dependent ecosystem, they provide potential therapeutic targets can be modulated new interventions for dysbiosis-related disorders, diseases. This article reviews modulation its relevance to brain exploring particular implications We will focus on three major factors are known those namely exercise, diet stress. Further exploration modulation, acting via both peripheral (e.g. metabolic dysfunction or 'metabolopathy') central direct effects CNS neurons glia) mechanisms, lead development novel approaches, such enviromimetics, wide

Language: Английский

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The integration of inflammaging in age-related diseases

Seminars in Immunology, Journal Year: 2018, Volume and Issue: 40, P. 17 - 35

Published: Oct. 2, 2018

Language: Английский

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Gut microbiota in neurodegenerative disorders

Journal of Neuroimmunology, Journal Year: 2019, Volume and Issue: 328, P. 98 - 104

Published: Jan. 9, 2019

Language: Английский

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Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

Acta Neuropathologica, Journal Year: 2018, Volume and Issue: 136(3), P. 345 - 361

Published: May 24, 2018

Language: Английский

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Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

Neurochemistry International, Journal Year: 2018, Volume and Issue: 120, P. 149 - 163

Published: Aug. 14, 2018

Language: Английский

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Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis

Frontiers in Integrative Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: Sept. 11, 2018

Mental disorders and neurological diseases have brought rapidly increasing medical burdens. Although extensive researches been conducted hugely, effective therapies still progressing slowly. Current dilemma reminds us that the human is a superorganism. Only if we take self its partner microbiota into consideration at same time can better understand these diseases. Over last few centuries, has experienced tremendous changes much more than own genes because of modern transformations in diet, lifestyle, care, so on, paralleling epidemiological transition. Existing research indicates gut plays an important role this According to gut–brain psychology, crucial part gut–brain, it communicates with brain via microbiota–gut–brain axis. The almost develops synchronously brain, mind. Gut influences various normal mental processes phenomena they are involved pathophysiology numerous Targeting therapy for promising approach supported by three theories: hypothesis, "old friend" leaky theory. effects behavior fulfilled through microbiota-gut-brain axis which mainly composed nervous pathway, endocrine immune pathway. Undoubtedly, psychology will bring great enhancement neuroscience, psychiatry. Various improving methods including FMT, probiotics, prebiotics, healthy lifestyle shown capability promote function brain. Harnessing improve health, prevent related be true future.

Language: Английский

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Alzheimer’s disease and gut microbiota modifications: The long way between preclinical studies and clinical evidence

Pharmacological Research, Journal Year: 2017, Volume and Issue: 129, P. 329 - 336

Published: Dec. 9, 2017

Language: Английский

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Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: A focus on human studies

Pharmacological Research, Journal Year: 2018, Volume and Issue: 131, P. 32 - 43

Published: March 17, 2018

Language: Английский

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Does Severity of Alzheimer's Disease Contribute to Its Responsiveness to Modifying Gut Microbiota? A Double Blind Clinical Trial

Frontiers in Neurology, Journal Year: 2018, Volume and Issue: 9

Published: Aug. 15, 2018

Alzheimer's disease (AD) is associated with cognitive dysfunction. Evidence indicates that gut microbiota altered in the AD and, hence, modifying flora may affect disease. In previous clinical research we evaluated effect of a probiotic combination on abilities patients. Since, addition to pathological disorders, changes oxidant/anti-oxidant and inflammatory/anti-inflammatory biomarkers, present work was designed evaluate responsiveness inflammatory oxidative biomarkers treatment. The control (CON) (PRO) patients were treated 3 months by placebo supplementation, respectively. cognitively assessed Test Your Memory (TYM=50 scores). Also serum concentrations nitric oxide (NO), glutathione (GSH), total antioxidant capacity (TAC), malondialdehyde (MDA), 8-hydroxy-2' -deoxyguanosine (8-OHdG) cytokines (TNF-a, IL-6 IL-10) measured. test pre- post-treatment. According TYM 83.5% showed severe AD. CON (12.86%±8.33) PRO (-9.35%±16.83) groups not differently scored cognitive. Not pronounced change percent found level TNF-α (1.67%±1.33 vs. -0.15%±0.27), (0.35%±0.17 2.18%±0.15) IL-10 (0.05%±0.10 -0.70%±0.73), TAC (0.07%±0.07 -0.06%±0.03), GSH (0.08%±0.05 0.04%±0.03), NO (0.11%±0.06 0.05%±0.09), MDA (-0.11%±0.03 -0.17%±0.03) 8-OHdG (43.25%±3.01 42.70%±3.27) groups, We concluded biochemical indications are insensitive supplementation. Therefore, formulation dosage bacteria, severity time administration deeply affects results

Language: Английский

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Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis

Frontiers in Aging Neuroscience, Journal Year: 2017, Volume and Issue: 9

Published: Dec. 7, 2017

Gut microbiota influences the central nervous system disorders such as Alzheimer's disease (AD). The prebiotics and probiotics can improve host cognition. A previous study demonstrated that fructooligosaccharides from Morinda officinalis (OMO) exert effective memory improvements in AD-like animals, thereby considered potential prebiotics; however, underlying mechanism still remains enigma. Thus, present investigated whether OMO is alleviating AD by targeting microbiota-gut-brain axis. was administered rats with symptoms (D-galactose- Aβ1-42-induced deficient rats). Significant systematic deterioration animals were identified, including learning abilities, histological changes, production of cytokines, microbial community shifts. Behavioral experiments administration ameliorate abilities both significantly. parameters showed cannot only oxidative stress inflammation disorder, but also regulate synthesis secretion neurotransmitter. Histological changes indicated ameliorates swelling brain tissues, neuronal apoptosis, down-regulation expression intracellular markers (Tau Aβ1-42). 16S rRNA sequencing gut maintains diversity stability community. In addition, regulated composition metabolism inflammatory bowel (IBD) mice model treated overdosed antibiotics thus prebiotic potential. Moreover, plays a major role neurodevelopment, leading to alterations gene critical intestinal regions, resulting perturbation programming normal cognitive behaviors. Taken together, our findings suggest therapeutic effect traditional medicine, M. officinalis, on various neurological diseases AD, at least partially contributed its naturally occurring chemical constituent, OMO, via modulating interaction between ecology physiology.

Language: Английский

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