Current Opinion in Systems Biology, Journal Year: 2023, Volume and Issue: 37, P. 100490 - 100490
Published: Nov. 23, 2023
Language: Английский
Nature Reviews Genetics, Journal Year: 2024, Volume and Issue: 25(9), P. 603 - 622
Published: April 24, 2024
Language: Английский
Citations
62
Engineering Science & Technology Journal, Journal Year: 2024, Volume and Issue: 5(4), P. 1395 - 1414
Published: April 17, 2024
This study provides a comprehensive review of the cutting-edge intersections biology and engineering in realm medical therapeutics, focusing on advancements applications synthetic biology. The main objectives were to explore historical evolution, define scope, analyze current state-of-the-art biology, particularly drug development treatment strategies. methodology employed systematic literature content analysis, utilizing range academic databases gather relevant peer-reviewed articles published between 2013 2023. Key findings revealED that through integration principles biological systems, has led significant innovations therapeutics. These include novel delivery targeted therapies, personalized medicine approaches. highlights challenges limitations approaches, such as ethical concerns, regulatory hurdles, need for interdisciplinary collaboration. future landscape is marked by both prospects. field holds immense potential addressing complex diseases enhancing healthcare delivery, yet faces considerations frameworks. Strategic recommendations are provided researchers, industry leaders, policymakers, emphasizing continuous innovation, applications, Finally, stands transformative force with revolutionize healthcare. Future research should focus overcoming exploring new ensuring field's continued advancement contribution global healthcare. Keywords: Synthetic Biology, Medical Therapeutics, Drug Development, Bioengineering.
Language: Английский
Citations
26
PLANT PHYSIOLOGY, Journal Year: 2024, Volume and Issue: 195(4), P. 2500 - 2514
Published: April 30, 2024
Over the past 10,000 years, tomato species have undergone both unintentional and intentional selection to enhance their favorable traits for human consumption manufacturing. These processes significantly influenced genomes of played a critical role in improving varieties. In this review, we summarize recent advances genome sequencing, explore impact human-driven selection, recapitulate key genes associated with important agronomic breeding. We provide several examples genomics-guided breeding highlight potential resources facilitating improvement. Furthermore, elaborate progress strategies through design present how such efforts can help future enhancements align demands sustainability evolving societies.
Language: Английский
Citations
15
Bioresource Technology, Journal Year: 2024, Volume and Issue: 399, P. 130614 - 130614
Published: March 19, 2024
Language: Английский
Citations
10
Cell Reports, Journal Year: 2024, Volume and Issue: 43(4), P. 113699 - 113699
Published: March 21, 2024
Over the past decade, rapid development of DNA synthesis and sequencing technologies has enabled preliminary use molecules for digital data storage, overcoming capacity persistence bottlenecks silicon-based storage media. now been fully accomplished in laboratory through existing biotechnology, which again demonstrates viability carbon-based However, high cost latency reconstruction pose challenges that hinder practical implementation beyond laboratory. In this article, we review advanced methods, analyze characteristics performance biotechnological approaches at various stages writing reading, discuss potential factors influencing from perspective reconstruction.
Language: Английский
Citations
9
Applied and Environmental Microbiology, Journal Year: 2024, Volume and Issue: 90(6)
Published: May 29, 2024
Glucaric acid (GA) is a value-added chemical and can be used to manufacture food additives, anticancer drugs, polymers. The non-genetic cell-to-cell variations in GA biosynthesis are naturally inherent, indicating the presence of both high- low-performance cells culture. Low-performance lead nutrient waste inefficient production. Furthermore,
Language: Английский
Citations
5
Science China Materials, Journal Year: 2024, Volume and Issue: 67(7), P. 2051 - 2066
Published: May 22, 2024
Language: Английский
Citations
4
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Nov. 30, 2023
The genome of an organism is inherited from its ancestor and continues to evolve over time, however, the extent which current version could be altered remains unknown. To probe plasticity Saccharomyces cerevisiae, here we replace native left arm chromosome XII (chrXIIL) with a linear artificial harboring small sets reconstructed genes. We find that as few 12 genes are sufficient for cell viability, whereas 25 required recover partial fitness defects observed in 12-gene strain. Next, demonstrate these can individually using synthetic regulatory sequences recoded open-reading frames "one-amino-acid-one-codon" strategy remain functional. Finally, neochromsome assembled substitute chrXIIL viability. Together, our work not only highlights high yeast genome, but also illustrates possibility making functional eukaryotic chromosomes entirely sequences.
Language: Английский
Citations
11
Cell Reports, Journal Year: 2024, Volume and Issue: 43(2), P. 113742 - 113742
Published: Feb. 1, 2024
In eukaryotic genomes, rDNA generally resides as a highly repetitive and dynamic structure, making it difficult to study. Here, synthetic array on chromosome III in budding yeast was constructed serve the sole source of rRNA. Utilizing loxPsym site within each repeat Cre recombinase, we were able reduce copy number few eight copies. Additionally, strains with two or three arrays found that presence multiple did not affect formation single nucleolus. Although alteration position impact three-dimensional genome additional had no deleterious influence cell growth transcriptomes. Overall, this study sheds light high plasticity organization opens up opportunities for future engineering.
Language: Английский
Citations
4
BioDesign Research, Journal Year: 2024, Volume and Issue: 6
Published: Jan. 1, 2024
Microbial cell factories (MCFs) are extensively used to produce a wide array of bioproducts, such as bioenergy, biochemical, food, nutrients, and pharmaceuticals, have been regarded the "chips" biomanufacturing that will fuel emerging bioeconomy era. Biotechnology advances led screening, investigation, engineering an increasing number microorganisms diverse MCFs, which workhorses help develop bioeconomy. This review briefly summarizes progress strategies in development robust efficient MCFs for sustainable economic biomanufacturing. First, comprehensive understanding microbial chassis cells, including accurate genome sequences corresponding annotations; metabolic regulatory networks governing substances, energy, physiology, information; their similarity uniqueness compared with those other microorganisms, is needed. Moreover, application effective tools crucial both model nonmodel cells into identification characterization biological parts, well design, synthesis, assembly, editing, regulation genes, circuits, pathways. also highlights necessity integrating automation artificial intelligence (AI) biotechnology facilitate future customized synthetic expedite industrialization process
Language: Английский
Citations
4