Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: April 18, 2024

Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. Peroxisome proliferator-activated receptors (PPARs) ligand-activated transcription control the expression multiple genes that involved in lipid metabolism inflammatory responses. However, synthesized PPAR agonists exhibit contrary therapeutic effects various side atherosclerosis therapy. Natural products structural diversity have a good safety. Recent studies find natural herbs compounds attractive on by alleviating hyperlipidemia inflammation through modulation PPARs. Importantly, preparation generally causes significantly lower environmental pollution compared to chemical compounds. Therefore, it is interesting discover novel modulator develop alternative strategies for therapy based This article reviews recent findings, mainly from year 2020 present, about roles regulation PPARs their provides theoretical basis using targeting PPARs, offers valuable information researchers interested developing modulators.

Language: Английский

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The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 2, 2024

Arterial hypertension represents a leading cause of cardiovascular morbidity and mortality worldwide, the identification effective solutions for treating early stages elevated blood pressure (BP) is still relevant issue risk prevention. The pathophysiological basis occurrence BP onset arterial have been widely studied in recent years. In addition, consistent progress development novel, powerful, antihypertensive drugs their appropriate applications controlling increased our potential successfully managing disease states characterized by abnormal pressure. However, mechanisms responsible disruption endogenous contributing to maintenance within normal range are yet be fully clarified. Recently, evidence has shown that several natural antioxidants containing active ingredients originating from plant extracts, used alone or combination, may represent valid solution counteracting hypertension. particular, there show enhance viability endothelial cells undergoing oxidative damage, an effect could play crucial role events accompanying present review aims reassess stress on dysfunction progression covering unmet needs treatment such diseases.

Language: Английский

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Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 1, 2024

Abstract Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal lead improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that medicine nanomaterials rapidly advancing making significant progress; however, bibliometric analysis knowledge mapping for currently lacking. We performed by retrieving publications related the Web of Science Core Collection (WoSCC) database spanning 2004 2023. Data processing was using R package Bibliometrix, VOSviewers, CiteSpace. Results In total, 1876 articles were identified, originating various countries, China being primary contributing country. The number in this field increases annually. Beijing University Chinese Medicine, Shanghai Traditional Saveetha India prominent institutions domain. Journal “International Nanomedicine” has highest publications. authors these reached 8234, Yan Zhao, Yue Zhang, Huihua Qu most prolific Zhao frequently cited author. “Traditional medicine,” “drug delivery,” “green synthesis” main focal points. Themes such as synthesis,” “curcumin,” “wound healing,” “carbon dots” may represent emerging areas. Conclusions Our study findings assist identifying latest frontiers hot topics, providing valuable references scholars investigating role nanotechnology medicine. Graphical

Language: Английский

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Complexity made easy: Aggregation‐induced emission small molecules for cancer diagnosis and phototherapies

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.

Language: Английский

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METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 4, 2024

Ischemic stroke (IS) is one of the principal causes disability and death worldwide. Berberine (BBR), derived from traditional Chinese herbal medicine Huang Lian, has been reported to inhibit progression stroke, but specific mechanism whereby BBR modulates ischemic remains unclear. N6-methyladenosine (m6A) modification most typical epigenetic mRNA post-transcriptional modifications, among which METTL3 common methylation transferase. During study, middle cerebral artery occlusion/reperfusion (MCAO/R) was established in mice, mice primary astrocytes neurons induced by oxygen-glucose deprivation/reoxygenation (OGD/R) simulated vitro. Level LncNEAT1, miR-377-3p detected via RT-qPCR. The levels Nampt were measured Western blot. CCK8 LDH assay performed detect cell viability. Here, we found that berberine alleviates MCAO/R-induced injury up-regulates expression astrocytes, inhibits after OGD/R, thus promoting neuronal injury. NEAT1 binds OGD/R plays a protective role as ceRNA. can enhance stability modulating m6A NEAT1. Taken together, our results demonstrate exerts neuroprotective effects methyltransferase METTL3, regulates NEAT1/miR-377-3p/Nampt axis mouse ameliorate ischemia/reperfusion (I/R)

Language: Английский

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