Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(5), P. 162 - 162
Published: Sept. 19, 2024
The
present
study
aimed
to
analyze
the
antifungal,
antioxidant,
and
irritant
potential
of
citronella
oil,
both
isolated
combined
with
caffeic
acid
phenethyl
ester
(CAPE),
for
topical
oral
candidiasis.
antioxidant
was
evaluated
using
two
methods,
DPPH
test
reducing
power
(FRAP),
while
solutions
assessed
through
hen’s
egg
chorioallantoic
membrane
(HET-CAM).
(IC50)
values
CITRO
III
+
CAPE
combination
were
32
±
9
mg/mL,
CAPE,
13
3
mg/mL.
results
from
FRAP
method
revealed
a
low
iron-reducing
1.25
mg/mL
0.0775
(CITRO
III),
showing
no
significant
difference
compared
solution
0.15
CAPE.
antibacterial
activity
in
vitro
against
microorganisms
methods:
microdilution
biofilm
assay.
showed
that
MIC
MFC
0.5
at
tested
times
(24
h
48
h).
For
0.031
assay,
compounds
combinations
1
min
6
significantly
different
controls
(p
<
0.05).
Furthermore,
HET-CAM
demonstrated
absence
irritability.
Based
on
these
premises,
antifungal
actions,
irritability
proven.
Moreover,
this
work
presents
natural
interest
pharmaceutical
industry.
Results in Chemistry,
Journal Year:
2023,
Volume and Issue:
6, P. 101179 - 101179
Published: Oct. 27, 2023
Three
prominent
health
challenges
affecting
our
society
include
cancer,
diabetes,
and
antibiotic-resistant
infections.
Despite
the
availability
of
conventional
drugs
for
these
conditions,
pervasive
problem
multidrug
resistance
significantly
diminishes
their
effectiveness.
Consequently,
it
is
paramount
to
prioritize
development
novel
drug
compounds
endowed
with
improved
desirable
therapeutic
properties.
Utilizing
metal-based
has
proven
be
an
effective
strategy
in
realm
anticancer
treatment
this
approach
holds
significant
promise
enhanced
multi-resistant
infections
diabetes.
Schiff
bases,
being
bioactive
organic
compounds,
have
attracted
considerable
attention.
Researchers
been
actively
exploring
potential
applications
metallo-based
including
heterocyclic
molecules
and/or
aromatic
rings
adorned
diverse
functional
groups
across
various
illnesses.
This
review
catalogs
(2010
2023)
classification
base
that
incorporate
groups,
which
possess
antimicrobial,
antidiabetic,
qualities.
These
insights
can
assist
medical
chemist
identifying
suitable
candidates
developing
innovative
pharmaceuticals.
Saudi Pharmaceutical Journal,
Journal Year:
2023,
Volume and Issue:
32(1), P. 101915 - 101915
Published: Dec. 10, 2023
In
this
study
we
presented
a
novel
series
of
NNO
tridentate
ligands
generating
imino,
amido
and
oxo
donor
pocket
for
Pd(II)
coordination.
All
the
compounds
were
meticulously
characterized
by
elemental
analysis
advanced
spectroscopic
techniques,
including
FTIR,
proton
carbon
NMR.
The
synthesized
underwent
rigorous
evaluation
their
potential
as
anti-cancer
agents,
utilizing
aggressive
breast
cancer
cell
lines
MDA-MB
(ATCC)
MCF-7
crucial
model
assessing
growth
inhibition
in
cells.
Remarkably,
MTT
assay
unveiled
robust
activity
all
palladium
complexes
against
MDA-MB-231
Particularly,
complex
[Pd(L1)(CH3CN)]
exhibited
exceptional
potency
with
an
IC50
value
25.50±0.30
µM
(MDA-MB-231)
20.76±0.30
(MCF-7),
compared
to
respective
27.00±0.80
24.10±0.80
cisplatin,
underscoring
its
promising
therapeutic
potential.
Furthermore,
elucidate
mechanistic
basis
effects,
molecular
docking
studies
on
tyrosine
kinases,
integral
target
research,
carried
out.
outcome
these
investigations
further
substantiated
remarkable
anticancer
properties
inherent
innovative
compounds.
This
research
offers
compelling
perspective
development
potent
agents
rooted
synergy
between
presenting
avenue
future
therapy
endeavors.
Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(5), P. 162 - 162
Published: Sept. 19, 2024
The
present
study
aimed
to
analyze
the
antifungal,
antioxidant,
and
irritant
potential
of
citronella
oil,
both
isolated
combined
with
caffeic
acid
phenethyl
ester
(CAPE),
for
topical
oral
candidiasis.
antioxidant
was
evaluated
using
two
methods,
DPPH
test
reducing
power
(FRAP),
while
solutions
assessed
through
hen’s
egg
chorioallantoic
membrane
(HET-CAM).
(IC50)
values
CITRO
III
+
CAPE
combination
were
32
±
9
mg/mL,
CAPE,
13
3
mg/mL.
results
from
FRAP
method
revealed
a
low
iron-reducing
1.25
mg/mL
0.0775
(CITRO
III),
showing
no
significant
difference
compared
solution
0.15
CAPE.
antibacterial
activity
in
vitro
against
microorganisms
methods:
microdilution
biofilm
assay.
showed
that
MIC
MFC
0.5
at
tested
times
(24
h
48
h).
For
0.031
assay,
compounds
combinations
1
min
6
significantly
different
controls
(p
<
0.05).
Furthermore,
HET-CAM
demonstrated
absence
irritability.
Based
on
these
premises,
antifungal
actions,
irritability
proven.
Moreover,
this
work
presents
natural
interest
pharmaceutical
industry.
