Rapid Plaque Progression Is Independently Associated With Hyperglycemia and Low HDL Cholesterol in Patients With Stable Coronary Artery Disease: A PARADIGM Study

Circulation Cardiovascular Imaging, Journal Year: 2024, Volume and Issue: 17(7)

Published: July 1, 2024

We assessed whether combinations of cardiometabolic risk factors independently predict coronary plaque progression (PP) and major adverse cardiovascular events in patients with stable artery disease.

Language: Английский

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Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 2, 2025

Adipose tissue distribution plays a crucial role in the development of cardiovascular complications. In particular, visceral adipose (VAT) has been linked to insulin resistance (IR) and disease (CVD). However, relationship between VAT, cardiac dysfunction meditation capacity VAT related IR not fully characterized. This cross-sectional study included adults living with type 2 diabetes (T2D). was measured using electrical bioimpedance also estimated Metabolic Score for Visceral Fat (METS-VF). LV function assessed left ventricular global longitudinal strain (LV-GLS) by speckle tracking echocardiography analysis. Spearman correlation coefficients, adjusted linear regression models guided direct acyclic diagrams causal mediation analysis were performed. Among 195 T2D (median age: 57, IQR: 49–64, women: 63%), showed positive association LV-GLS (β = 0.482, 95% CI: 0.060–0.904, p 0.039) after adjusting relevant confounders. The effect strongly replicated METS-VF as surrogate VAT. revealed that accounted 60.9% (95% 15.82–171) total LV-GLS. demonstrated consistently observed clinical METS-VF. adiposity identified strong mediator LV-GLS, underscoring its pathophysiology patients T2D. Summary main results study. Abbreviations: T2D: Type diabetes, Left-ventricular strain; VAT: tissue; METS-VF, Fat.

Language: Английский

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Predicted visceral adiposity index in relation to risk of coronary heart disease and all-cause mortality: insights from NHANES

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

The Visceral Adiposity Index (VAI) is a straightforward and gender-specific marker that combines anthropometric measurements with lipid profiles. objective of this study was to evaluate the relationship between VAI coronary heart disease (CHD).

Language: Английский

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Is Metabolic Score for Visceral Fat (METS-VF) a Better Index Than Other Adiposity Indices for the Prediction of Visceral Adiposity

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2023, Volume and Issue: Volume 16, P. 2605 - 2615

Published: Aug. 1, 2023

Visceral adiposity is an important risk factor for cardiometabolic diseases.To determine whether the Metabolic Score Fat (METS-VF) more effective than other indices in predicting visceral fat area (VFA).In this single-center and cross-sectional study, we included patients aged 20-50 years, without diabetes coronary artery disease, who underwent computed tomography (CT) including third lumbar vertebra. Age, blood pressure, waist circumference (WC), hip circumference, fasting lipids, glucose were assessed. VFA was measured by examination of CT. The correlation WC, body mass index (BMI), waist-hip ratio (WHR), lipid accumulation product (LAP), (VAI), a shape (ABSI), roundness (BRI), METS-VF with analyzed analysis. cut-off values under curve (AUC) identifying increased (>130 cm2) determined.We 185 individuals mean age 38.2 ± 8 female predominance (58.4%). There significant positive between all (p<0.001). ROC analysis revealed that WC demonstrated highest predictive value VFA. In both men (p=0.001) women (p<0.001), (AUC 0.922 0.939, respectively) showed superiority over ABSI 0.702 0.658, respectively), VAI 0.731 0.725, respectively). Additionally, women, its WHR 0.807) also statistically (p=0.003). We identified point >6.4 males >6.5 females >88 cm 0.922), >90.5 0.938).METS-VF strongly associated better to predict However, BMI, BRI, LAP not significant. results emphasize appealing as screening indicator considering easy use.Clinicaltrials.gov (http://www.clinicaltrials.gov).https://clinicaltrials.gov/ct2/show/NCT05648409.NCT05648409.

Language: Английский

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Correlation Between Metabolic Score for Visceral Fat and Cardiovascular-Kidney-Metabolic Syndrome: Analysis of NHANES 2011–2020

Healthcare, Journal Year: 2025, Volume and Issue: 13(7), P. 694 - 694

Published: March 21, 2025

Background: Cardiovascular-kidney-metabolic (CKM) syndrome with high incidence and mortality rates is a prevalent health issue globally. The Metabolic Score for Visceral Fat (METS-VF), as new index valuating visceral adipose tissue, has been reported to be closely related variety of diseases. However, whether the METS-VF can an indicator predict risk CKM remains unclear. Methods: We selected National Health Nutrition Examination Survey (NHANES) database data from 2011-2020 year cycles conducted analyses between utilizing weighted Cox regression models, subgroup interaction analysis, restricted cubic spline (RCS) analysis. also used receiver operating characteristic (ROC) curves analyze compare diagnostic predictive ability METS-VF, BMI, other indicators assessing including VAI, fat mass, lean in syndrome. Results: In this study, average age was 34.40 ± 0.61 years non-CKM patients, while over 40.38 0.62 patients. Additionally, there greater proportion male patients (over 49.04%) comparison (37.94%). higher 6.63 0.02) compared (5.62 0.03). found had positive correlation hardly affected by confounding factors. more associated 20-59 female addition, better than body mass (BMI) indicators. Conclusions: potentially actionable that risk. may possible reference management

Language: Английский

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Metabolic score for visceral fat is correlated with all-cause and cardiovascular mortality among individuals with non-alcoholic fatty liver disease

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 10, 2025

Metabolic score for visceral fat (METS-VF) as an effective marker of obesity has been correlated with non-alcoholic fatty liver disease (NAFLD). This study aims to explore the correlation between METS-VF and both all-cause mortality cardiovascular (CVD)-related among individuals NAFLD. A cohort 6,759 subjects diagnosed NAFLD was selected from NHANES during period 1999 2018. Within this cohort, prognostic utility predicting CVD-related assessed. There a total 1254 deaths (18.6%) 418 (6.2%) at median follow-up 9.3 years. Multivariate Cox regression analysis restricted cubic splines indicated that can exhibit positive non-linearly CVD (HR: 4.15, 95% CI: 2.31-7.44, p < 0.001) 5.27, 3.75-7.42, 0.001), identified inflection point 7.436. Subgroup analyses further revealed stronger without diabetes. Furthermore, areas under curve (AUC) 1-, 3-, 5-, 10-year survival rates were 0.756, 0.740, 0.747 0.746 mortality, 0.774, 0.751, 0.758 respectively, which performs better than other IR related index. Elevated independently contributes increased risk in Not applicable.

Language: Английский

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Association between metabolic score of visceral fat and carotid atherosclerosis in Chinese health screening population: a cross-sectional study

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 28, 2024

Abstract Background The metabolic score for visceral fat (METS-VF) quantifies the cumulative burden of and intra-abdominal adipose tissues. However, relationship between METS-VF carotid atherosclerosis (CAS) has not been extensively explored. Therefore, this study aimed to investigate association CAS. Methods This cross-sectional enrolled 7089 Chinese adults who underwent physical examinations at Zhenhai Lianhua Hospital, Zhejiang, China, in 2020. Multivariable logistic regression analysis was used explore linear Generalised additive models (GAM) were employed evaluate potential nonlinear associations. inflection points determined using segmented optimised maximum likelihood ratios recursive algorithms. Results revealed a positive correlation CAS (odds ratio [OR]: 1.824, 95% confidence interval [CI]: 1.753–1.899; P < 0.001). GAM confirmed them [effective degrees freedom: 4.803, χ 2 : 876.7, 0.001], with an point 8.09 ( 0.001 log-likelihood test). Below point, exhibited significant risk (OR: 1.874, CI: 1.796–1.954; Conversely, no observed when ≥ 0.998, 0.786–1.268; = 0.989). Conclusions demonstrated non-linear correlation, curve indicating saturation effect 8.09.

Language: Английский

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Association of metabolic score for visceral fat with all‐cause mortality, cardiovascular mortality, and cancer mortality: A prospective cohort study

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(12), P. 5870 - 5881

Published: Oct. 3, 2024

Abstract Aim Our study aimed to evaluate the association between metabolic score for visceral fat (METS‐VF) and mortality. Methods We conducted a cohort comprising 11,120 participants. employed weighted multivariable Cox regression analysis assess relationship METS‐VF Restricted cubic spline analyses were used investigate potential non‐linear associations. Receiver operating characteristic curves predictive value of other obesity‐related indicators Subgroup sensitivity performed confirm robustness results. Mendelian randomization was utilized causality. Results Over median follow‐up duration 83 months, total 1014 all‐cause deaths, 301 cardiovascular 262 cancer deaths occurred. For every 0.2‐unit increase in METS‐VF, hazard ratios(HRs) mortality, mortality 1.13 [95% confidence interval (CI): 1.06, 1.20], 1.18 (95% CI: 1.31), 1.03, 1.25), respectively. In addition, restricted revealed no significant associations multivariate models, ratios higher highest group compared reference group. confirmed that our results robust. indicated predicted better than indicators. causal relationships. Conclusions positively associated with These findings suggest could serve as straightforward, reliable, cost‐effective marker identifying individuals at high risk

Language: Английский

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The Complement System as a Part of Immunometabolic Post-Exercise Response in Adipose and Muscle Tissue

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11608 - 11608

Published: Oct. 29, 2024

The precise molecular processes underlying the complement's activation, which follows exposure to physical stress still remain be fully elucidated. However, some possible mechanisms could play a role in initiating changes activity, are observed post-exposure stimuli. These mainly based on metabolic shifts that occur microenvironment of muscle tissue while performing its function with increased intensity, as well adipose tissue's sterile inflammation and adipokine secretion. This review aims discuss current opinions link between complement activation diet, age, sex, health disorders particular emphasis endocrinopathies and, furthermore, type activity overall fitness. It has been indicated regular incorporated into therapeutic strategies potentially improves management diseases, such as, e.g., autoimmune conditions. Moreover, it represents favorable influence immunoaging processes. A better understanding system's interaction will support established clinical therapies targeting components.

Language: Английский

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Medial arterial calcification of the lower limbs in diabetes: Time for awareness? A short narrative review

Diabetes & Metabolism, Journal Year: 2024, Volume and Issue: 51(1), P. 101586 - 101586

Published: Nov. 7, 2024

Language: Английский

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