Revista Brasileira de Farmacognosia, Journal Year: 2023, Volume and Issue: 33(3), P. 617 - 628
Published: April 11, 2023
Language: Английский
Endocrinology and Metabolism Clinics of North America, Journal Year: 2023, Volume and Issue: 52(3), P. 445 - 457
Published: Feb. 26, 2023
Language: Английский
Citations
24
Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1494 - 1494
Published: March 27, 2024
Detailed investigation of the lipidome remodeling upon normal weight conditions, obesity, or loss, as well influence physical activity, can help to understand mechanisms underlying dyslipidemia in metabolic conditions correlated emergence and progression non-alcoholic fatty liver disease (NAFLD). C57BL/6 male mice were fed a diet (ND) high-fat (HFD) for 20 weeks. Subgroups within group underwent different interventions: some engaged exercise (HFDex), others subjected loss (WL) by changing from HFD ND, combination (WLex) during final 8 weeks 20-week feeding period. To support our understanding, not only tissue-specific lipid but also cross-talk between tissues their impact on systemic regulation metabolism are essential. Exercise loss-induced specific adaptations visceral adipose tissue lipidomes explored UPLC–TOF–MS/MS untargeted lipidomics methodology. Lipidomic signatures ND HFD-fed undergoing compared with animals without exercise. Several classes identified contributing factors discrimination groups multivariate analysis models, such glycerolipids, glycerophospholipids, sphingolipids, acids, respect samples, whereas triglycerides class tissue. Lipids found be dysregulated related well-established pathways involved biosynthesis PC, PE, TG metabolism. These show reversing trend back basic levels when change after 12 weeks, exercise, though cases it slightly enhances trend, is clear.
Language: Английский
Citations
10
Current Diabetes Reports, Journal Year: 2024, Volume and Issue: 24(7), P. 158 - 166
Published: May 3, 2024
Language: Английский
Citations
9
BMC Medical Imaging, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 20, 2025
The purpose of our study was to investigate the association between non-alcoholic fatty liver disease (NAFLD) and abdominal aortic aneurysms (AAA) progression using non-enhanced computed tomography (CT) CT angiography (CTA). Patients with AAA age- sex-matched healthy subjects who underwent CTA examination January 2015 2023 from four hospitals were retrospectively analyzed. divided into (growth rate > 10 mL/year) non-progression groups, as well those NAFLD without NAFLD, based on results. Kaplan-Meier Cox regression used progression. A total 151 patients (mean age: 69.1 ± 10.5 years old, 133 men) included, among which 66 (43.7%) had NAFLD. During a median 10.7 months (6.0–76.0 months), 57 (37.7%) prevalence significantly higher in group compared control (43.7% vs. 31.1%, p = 0.024). Multivariable analysis revealed that independently associated (HR, 4.28; 95% CI, 2.20–8.31; < 0.001). area under curve combined maximal diameter 0.857 for predicting is an independent predictor It can improve diagnostic efficacy aneurysms. Not applicable. This research retrospective analysis.
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 433 - 456
Published: Feb. 11, 2025
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 1, 2024
Language: Английский
Citations
6
Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 1043 - 1043
Published: Feb. 20, 2023
Gut microbiota imbalances lead to the pathogenesis of non-alcoholic fatty liver disease (NAFLD), which is primarily accompanied by hepatic steatosis. Hydroxyphenyl propionic acids (HPP) have shown great potential in inhibiting lipid accumulation but their protective effects concerning NAFLD and intestinal remained unclear. In this paper, we investigated efficacies 3-HPP 4-HPP on steatosis gut flora mice fed a high-fat diet (HFD). We found that administration decreased body weight index, ameliorated dyslipidemia, alleviated Furthermore, enhanced multiformity microbiota; improved relative abundance GCA-900066575, unidentified_Lachnospiraceae, Lachnospiraceae_UCG-006 at genus level; increased concentration acetic acid, acid butanoic faeces; reduced systemic endotoxin levels mice. Moreover, upregulated genera Rikenella downregulated Faecalibaculum. regulated metabolism dysbiosis was more effective than 3-HPP.
Language: Английский
Citations
16
Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1954 - 1954
Published: April 19, 2023
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic disease. Fucoxanthin, a red-orange marine carotenoid, found in natural seaweeds with high antioxidant activity and several other remarkable biological features. The aim this review to gather evidence positive benefits fucoxanthin on NAFLD. Fucoxanthin provides an extensive list physiological properties, such as hepatoprotective, anti-obesity, anti-tumor, anti-diabetes addition anti-inflammatory properties. This focuses published research preventative effects NAFLD from perspective human clinical trials, animal experiments vivo, vitro cell investigations. Using variety experimental designs, including treatment dosage, experiment model, periods, were demonstrated. Fucoxanthin’s activities outlined, emphasis its therapeutic efficacy showed beneficial modulating lipid metabolism, lipogenesis, acid oxidation, adipogenesis, oxidative stress A deeper comprehension pathogenesis essential for development novel effective strategies.
Language: Английский
Citations
11
Cellular Signalling, Journal Year: 2024, Volume and Issue: 121, P. 111299 - 111299
Published: July 14, 2024
Language: Английский
Citations
4
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117805 - 117805
Published: Jan. 5, 2025
Language: Английский
Citations
0