Aquaculture, Journal Year: 2021, Volume and Issue: 550, P. 737847 - 737847
Published: Dec. 23, 2021
Language: Английский
Pharmacological Research, Journal Year: 2022, Volume and Issue: 182, P. 106321 - 106321
Published: June 22, 2022
The role of gut microbiota in regulating the intestinal homeostasis, as well pathogenesis severe acute pancreatitis-associated lung injury (PALI) is widely recognized. bioactive functions metabolites with small molecule weight and detail molecular mechanisms PALI mediated by "gut-lung axis" have gradually raised attentions researchers. Several studies proved that short-chain fatty acids (SCFAs) produced microbiome play crucial roles varied activities process PALI. However, relevant reviews reporting SCFAs involvement lacking. In this review, we firstly introduced synthetic metabolic pathways SCFAs, transport signal transduction routes brief. Afterwards, focused on possible clues to participate fight against which referred inhibition pathogen proliferation, anti-inflammatory effects, enhancement barrier functions, maintenance regulation immune homeostasis via pathogen-associated patterns (PAMPs) damage-associated (DAMPs). addition, latest reported pathological physiological gut-lung axis involved were reviewed. Finally, summarized potential therapeutic interventions targeting including dietary fiber supplementation, direct supplementation SCFAs/prebiotics/probiotics, drugs administration, expected provide new sights for clinical use future.
Language: Английский
Citations
53
Clinical Nutrition, Journal Year: 2022, Volume and Issue: 41(8), P. 1680 - 1688
Published: June 15, 2022
Background and aimsWe aimed to describe characterize the gut microbiota composition diversity in children with obesity according their metabolic health status.MethodsAnthropometry, Triglycerides, HDL cholesterol, HOMA-IR, systolic diastolic blood pressure (SBP, DBP) were evaluated (and z-score calculated) faecal samples collected from 191 aged 8 14. All classified depending on cardiometabolic status either a "metabolically healthy" (MHO; n = 106) or unhealthy" (MUO; 85) group. Differences taxonomies between groups (MUO vs MHO) analysed. Alpha index was calculated as Chao1 Simpson's index, β-diversity Adonis Bray–Curtis index. Spearman's correlations logistic regressions performed study association microbiota.ResultsChildren MUO presented significantly lower alpha richness than those MHO group (Chao1 p 0.021, 0.045, respectively), whereas did not differ by (Adonis Bray–Curtis, R2 0.006; 0.155). The characterized relative abundances of genera Christensenellaceae R7 (MHO:1.42% [0.21–2.94]; MUO:0.47% [0.02–1.60], < 0.004), Akkermansia (MHO:0.26% [0.01–2.19]; MUO:0.01% [0.00–0.36], 0.001) higher Bacteroides (MHO:10.6% [4.64–18.5]; MUO:17.0% [7.18–27.4], 0.012) genus. After adjustment sex, age, BMI, (OR: 0.86, CI: 0.75–0.97; 0.033), 95% 075–0.98; 0.031) 0.96–1.00; 0.023) represented risk presence one more altered cardiovascular factors.ConclusionLower proportions seem be indicators unhealthy obesity.
Language: Английский
Citations
47
Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 146, P. 109376 - 109376
Published: Jan. 11, 2024
Language: Английский
Citations
14
ACS Omega, Journal Year: 2024, Volume and Issue: 9(13), P. 14648 - 14671
Published: March 19, 2024
The microbiome is an integral part of the human gut, and it plays a crucial role in development immune system homeostasis. Apart from gut microbiome, airway microbial community also forms distinct microbiota. Furthermore, several studies indicate existence communication between their metabolites with lung airways, called "gut–lung axis". Perturbations microbiota composition, termed dysbiosis, can have acute chronic effects on pathophysiology diseases. Microbes stimulate various innate pathways, which modulate expression inflammatory genes pulmonary leukocytes. For instance, microbiota-derived such as short-chain fatty acids suppress inflammation through activation G protein-coupled receptors (free acid receptors) inhibit histone deacetylase, turn influences severity respiratory Thus, modulation composition probiotic/prebiotic usage fecal transplantation lead to alterations homeostasis immunity. resulting manipulation cells function key paves way for novel therapeutic strategies improving health individuals affected diseases including SARS-CoV-2. This review will shed light upon mechanistic aspect programming exploration relationship gut–lung highlight potential management
Language: Английский
Citations
14
Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: 2024(1)
Published: Jan. 1, 2024
Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when used as dietary supplement. In vitro vivo , lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions diseases including inflammation, obesity, diabetes mellitus. shown alleviate affect the bone, eye, kidney, liver, lungs, heart, nervous system. This review presents state of art regarding lycopene’s benefits its potential applications system delivery. Furthermore, protective effects against toxins, safety use, possible toxicity are explored.
Language: Английский
Citations
13
Physiological Reports, Journal Year: 2022, Volume and Issue: 10(7)
Published: April 1, 2022
Obesity is an increasing global health concern and associated with a broad range of morbidities. The gut microbiota are increasingly recognized as important contributors to obesity cardiometabolic health. This study aimed characterize oral microbial communities, evaluate host: interactions between clinical classifications. We performed 16S rRNA sequencing on fecal salivary samples, metabolomics profiling plasma stool dietary in 135 healthy individuals. grouped individuals by status, based body mass index (BMI), including lean (BMI 18-124.9), overweight 25-29.9), or obese ≥30). analyzed differences microbiome composition, community inter-relationships, predicted function status. found that bacterial communities were compositionally phylogenetically distinct. An increase status was positively strong correlations taxa, particularly groups implicated metabolic disorders Fretibacterium, Tannerella. Consumption sweeteners, especially xylitol, significantly influenced compositional phylogenetic diversities communities. In addition, exhibited activity, which correlated host's metabolite concentrations. Overall, distinct changes dynamics, saliva. Consideration structure inclusion samples may improve our ability understand pathways linking disease.
Language: Английский
Citations
33
microLife, Journal Year: 2023, Volume and Issue: 4
Published: Jan. 1, 2023
Adult humans harbor at least as many microbial cells eukaryotic ones. The largest compartment of this diverse population, the gut microbiota, encompasses collection bacteria, archaea, viruses, and organisms that populate gastrointestinal tract, represents a complex dynamic ecosystem has been increasingly implicated in health disease. microbiota carries ∼100-to-150-times more genes than human genome is intimately involved development, homeostasis, Of several metabolites have studied, short-chain fatty acids emerge group molecules shape gene expression types by multiple mechanisms, which include DNA methylation changes, histone post-translational modifications, microRNA-mediated silencing. Butyric acid, one most extensively studied acids, reaches higher concentrations colonic lumen, where it provides source energy for healthy colonocytes, its decrease towards bottom crypts, stem reside. lower butyric acid concentration crypts allows undifferentiated cells, such to progress through cell cycle, pointing importance providing them with protective niche. In cancerous metabolize relatively little mostly rely on glycolysis, preferentially acts deacetylase inhibitor, leading decreased proliferation increased apoptosis. A better understanding interface between epigenetic changes promises unravel detail processes occur physiologically part disease, help develop novel biomarkers, identify new therapeutic modalities.
Language: Английский
Citations
21
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 131872 - 131872
Published: April 25, 2024
The increasing incidence of obesity has led to widespread attention in the exploration natural ingredients. Ginseng polysaccharides (PGP), main components from Panax ginseng, have been reported potential effect attenuate and regulate lipid metabolism. In this study, we found that PGP inhibited high-fat diet (HFD)-induced weight gain, fat ratio tissue after 8-week administration. Serum liver analysis showed decreased levels triglyceride total cholesterol, which was mediated by inhibition key genes for fatty acid cholesterol metabolisms. Metabolomics studies inhibitory on accumulation significantly correlated with its regulation citric cycle lysine degradation. regulated expression related degradation both hepatocytes. addition, reshaped composition fecal microbiota at genus species obese mice. Spearman's correlation demonstrated Staphylococcus sciuri, lentus, Pseudoflavonifractor sp. An85 may be targets maintains abundance l-lysine against obesity. It concluded can regulating hepatic
Language: Английский
Citations
7
Molecules, Journal Year: 2021, Volume and Issue: 26(13), P. 4010 - 4010
Published: June 30, 2021
Resveratrol butyrate esters (RBE) are derivatives of resveratrol (RSV) and butyric acid exhibit biological activity similar to that RSV but with higher bioavailability. The aim this study was designed as an animal experiment explore the effects RBE on serum biochemistry, fat deposits in offspring rats exposed bisphenol A (BPA), along growth decline gut microbiota. We constructed model perinatal Bisphenol (BPA) exposure observe supplementation obesity, blood lipids, intestinal microbiota female rats. Perinatal BPA led weight gain, lipid accumulation, high levels deterioration reduced gain accumulation caused by BPA, optimised significantly Firmicutes/Bacteroidetes (F/B) ratio, increased decreased abundance S24-7 Lactobacillus, respectively. analysis faecal short-chain fatty (SCFA) revealed concentration acetate, which could be via supplementation. However, concentrations propionate were not only lower than also did change response or Hence, can suppress BPA-induced obesity rats, it demonstrates excellent modulatory microbiota, potential applications perinatological research.
Language: Английский
Citations
36
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: July 11, 2022
Metabolic hypertension (MH) is the most common type of worldwide because unhealthy lifestyles, such as excessive alcohol intake and high-sugar/high-fat diets (ACHSFDs), adopted by humans. Poor lead to a decrease in synthesis short-chain fatty acids (SCFAs), which are produced intestinal flora transferred G protein-coupled receptors (GPCRs), resulting impaired gastrointestinal function, disrupted metabolic processes, increased blood pressure (BP), ultimately, MH. It not clear whether Dendrobium officinale polysaccharide (DOPS) can mediate its effects triggering SCFAs-GPCR43/41 pathway. In this study, DOPS, with content 54.45 ± 4.23% composition mannose, glucose, galacturonic acid at mass percentages 61.28, 31.87, 2.53%, was isolated from officinale. observed that given rats intragastric administration after dissolution, could lower BP improve abnormal lipid processes ACHSFD-induced MH rats. Moreover, DOPS found increase production, transportation, utilization SCFAs, while improving strengthening barrier, well increasing levels SCFAs expression GPCR43/41. Furthermore, improved vascular endothelial function GPCR41 nitric oxide synthase aorta level serum. However, these were all reversed antibiotic use. These findings indicate active component officinale, it reverse activating
Language: Английский
Citations
25