Grape Pomace—Advances in Its Bioactivity, Health Benefits, and Food Applications

Foods, Journal Year: 2024, Volume and Issue: 13(4), P. 580 - 580

Published: Feb. 14, 2024

From a circular economy perspective, the appropriate management and valorization of winery wastes by-products are crucial for sustainable development. Nowadays, grape pomace (GP) has attracted increasing interest within food field due to its valuable content, comprising nutritional bioactive compounds (e.g., polyphenols, organic fatty acids, vitamins, etc.). Particularly, GP polyphenols have been recognized as exhibiting technological health-promoting effects in different biological systems. Hence, is step toward offering new functional foods contributing solving waste problems wine industry. On this basis, use additive/ingredient development novel products with advantages recently proposed. In review, we summarize current knowledge on bioactivity polyphenolic-rich extracts from samples. Advances incorporation into formulations (enhancement physicochemical, sensory, quality) information supporting intellectual property related potential applications industry also discussed.

Language: Английский

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Pulsed electric fields-assisted extraction of valuable compounds from red grape pomace: Process optimization using response surface methodology

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 17, 2023

Background The application of Pulsed electric fields as a mild and easily scalable electrotechnology represents an effective approach to selectively intensify the extractability bioactive compounds from grape pomace, one most abundant residues generated during winemaking process. Objective This study addressed optimization pulsed (PEF)-assisted extraction enhance yields red pomace using response surface methodology (RSM). Methods cell disintegration index (Z p ) was identified variable determine optimal PEF processing conditions in terms field strength (E = 0.5–5 kV/cm) energy input (W T 1–20 kJ/kg). For solid-liquid (SLE) process effects temperature (20–50°C), time (30–300min), solvent concentration (0–50% ethanol water) on total phenolic content (TPC), flavonoid (FC), anthocyanin (TAC), tannin (TC), antioxidant activity (FRAP) extracts untreated PEF-treated plant tissues were assessed. composition obtained determined via HPLC-PDA. Results demonstrated that at 4.6 kV/cm, W 20 kJ/kg) significantly enhanced permeabilization degree membrane tissues, thus intensifying subsequent TPC (15%), FC (60%), TAC (23%), TC (42%), FRAP values (31%) concerning control extraction. HPLC-PDA analyses showed that, regardless PEF, epicatechin, p-coumaric acid, peonidin 3-O-glucoside, no degradation specific occurred upon application. Conclusion PEF-assisted allowed high-value-added supporting further investigations this larger scale.

Language: Английский

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Therapeutic potential of grape pomace extracts: A review of scientific evidence

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104210 - 104210

Published: May 4, 2024

Grape pomace is widely studied as a source of phenolic compounds. These secondary metabolites are recognized by presenting pharmacological properties such antioxidant, antimicrobial, anti-tyrosinase, vasodilating, anti-inflammatory, antihyperglycemic and antitumoral, that can be exploited in new sustainable therapies. In this review, we gather scientific evidences biological extracts individual from grape through vitro, vivo or silico studies. more specific approach, discuss the mechanisms action these compounds therapeutical agents to prevent treat diabetes mellitus, cardiovascular neurodegenerative diseases cancer. The outcomes studies evaluated show have high potential administrated supplements even incorporated medicine formulations. However, researchers suggesting mechanism responsible for their effects, pathways not completely elucidated. Furthermore, there still lack obtain consistent evidences.

Language: Английский

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Pressurized liquid extraction as an innovative high-yield greener technique for phenolic compounds recovery from grape pomace

Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 40, P. 101635 - 101635

Published: June 5, 2024

Language: Английский

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Rapid screening of the novel bioactive peptides with notable α-glucosidase inhibitory activity by UF-LC-MS/MS combined with three-AI-tool from black beans

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 130982 - 130982

Published: March 24, 2024

Language: Английский

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Incorporating the HPLC‐ESI‐Q‐TOF‐MS profiles with the biochemical properties of eight Salvia species

eFood, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 2, 2025

Abstract Salvia , a widely recognized genus globally esteemed for its traditional and medicinal applications, prompted our investigation into the methanol water extracts of eight species native to Turkey. These included S. aucheri, candidissima, divaricata, virgata, multicaulis, palestina, trichoclada cerino‐pruinosa . Our study aimed assess their biological properties chemical composition. Utilizing HPLC‐ESI‐Q‐TOF‐MS, we identified constituents in extracts, while antioxidant (radical quenching, reducing power, metal chelating) enzyme inhibitory (amylase, glucosidase, tyrosinase, cholinesterase) activities were evaluated activities. One hundred thirty‐one compounds characterized tested extracts. Although many belonging different families identified, main all rosmarinic sagerinic acids, along with several salvianolic acid isomers. Notably, displayed superior overall, exhibiting highest activity among them, except chelating. Similar test results, more active than inhibition tests. Multivariate analysis further highlighted distinctiveness extract In conclusion, findings underscore biopharmaceutical potential species, suggesting significance as sources bioactive agents health‐promoting applications.

Language: Английский

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Comparative Evaluation of the Antidiabetic potential of three varieties of Ipomoea batatas L.

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 102015 - 102015

Published: March 28, 2025

Sweet potato (Ipomoea batatas L.) is a nutrient-dense tuber often used in traditional diabetic treatment. This research compares the antidiabetic potential of three sweet varieties: orange-fleshed (OFSP), purple-peel white-fleshed (PPWSP), and white-peel (WPWSP), utilising vitro vivo techniques. potatoes (OFSP, PPWSP, WPWSP) boiled at 100°C for 20 minutes were incorporated into formulated diets administered to streptozotocin-induced rats 14 days. Aqueous extracts tested antioxidants phytochemicals. Glycaemic control parameters, lipid profiles, oxidative stress indicators, pancreatic histology investigated. Gene expression analysis was performed on critical diabetes-related pathways. OFSP showed significant strong anti-diabetic benefits, including better glycemic control, weight maintenance, lower HOMA-IR scores, lowered α-amylase α-glucosidase activity. OFSP-fed had higher insulin, glycogen, hexokinase activity than those given PPWSP WPWSP. decreased mRNA DPP-4 while increasing GLP-1 expression. also improved HDLc decreasing LDLc triglycerides more other varieties. Histopathological examination revealed restorative effects beta cells. demonstrated pronounced compared WPWSP, particularly terms insulin regulation, profile improvement. These findings suggest that may offer diabetes management. However, further clinical studies are needed validate these results explore practical dietary applications control.

Language: Английский

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Grape Pomace as a Cardiometabolic Health-Promoting Ingredient: Activity in the Intestinal Environment

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 979 - 979

Published: April 21, 2023

Grape pomace (GP) is a winemaking by-product particularly rich in (poly)phenols and dietary fiber, which are the main active compounds responsible for its health-promoting effects. These components their metabolites generated at intestinal level have been shown to play an important role promoting health locally systemically. This review focuses on potential bioactivities of GP environment, primary site interaction food biological activities. mechanisms include (i) regulation nutrient digestion absorption (GP has inhibit enzymes such as α-amylase α-glucosidase, protease, lipase, can help reduce blood glucose lipid levels, modulate expression transporters, also regulate absorption); (ii) modulation gut hormone levels satiety stimulates GLP-1, PYY, CCK, ghrelin, GIP release, appetite satiety); (iii) reinforcement morphology (including crypt-villi structures, improve protect against damage); (iv) protection barrier integrity (through tight junctions paracellular transport); (v) inflammation oxidative stress triggered by NF-kB Nrf2 signaling pathways; (vi) impact microbiota composition functionality (leading increased production SCFAs decreased LPS). The overall effect within environment reinforces function first line defense multiple disorders, including those impacting cardiometabolic health. Future research GP’s properties should consider connections between other organs, gut-heart axis, gut-brain gut-skin oral-gut axis. Further exploration these connections, more human studies, will solidify ingredient contribute prevention management cardiovascular diseases.

Language: Английский

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Phytofabrication of Selenium Nanoparticles with Moringa oleifera (MO-SeNPs) and Exploring Its Antioxidant and Antidiabetic Potential

Molecules, Journal Year: 2023, Volume and Issue: 28(14), P. 5322 - 5322

Published: July 10, 2023

The advancement in nanotechnology is the trigger for exploring synthesis of selenium nanoparticles and their use biomedicine. Therefore, this study aims to synthesize using M. oleifera as a reducing agent evaluate antioxidant antidiabetic potential. Our result demonstrated change color mixture from yellow red, UV-Vis spectrometry suspension solution confirmed formation MO-SeNPs with single absorbance peak range 240-560 nm wavelength. FTIR analysis revealed several bioactive compounds, such phenols amines, that could possibly be responsible reduction stabilization MO-SeNPs. FESEM + EDX amorphous are high purity, have spherical shape, size 20-250 diameter, determined by HRTEM. also exhibit highest DPPH scavenging activity 84% at 1000 μg/mL an IC50 454.1 noteworthy ability power assay. Furthermore, showed promising properties dose-dependent inhibition α-amylase (26.7% 44.53%) α-glucosidase enzyme (4.73% 19.26%). Hence, these results plant extract possesses potential reduce ions SeNPs under optimized conditions notable activities.

Language: Английский

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Sustainable extraction methods for the recovery of polyphenolic compounds from grape pomace and its biological properties: a comprehensive review

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: July 5, 2024

Language: Английский

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