Cadmium and silver complexes of a pyridine containing ligand: syntheses, structural studies, biological activity and docking studies DOI Creative Commons
Azza A. Hassoon, Stacey J. Smith, Roger G. Harrison

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(43), P. 31850 - 31860

Published: Jan. 1, 2024

Novel complexes of Cd( ii ) and Ag( i derived from TPT ligand have been synthesized. The silver showed great potential as a therapeutic candidate for treating breast cancer.

Language: Английский

Organotellurium compounds: an overview of synthetic methodologies DOI
Muhammad Irfan, Rabia Rehman, Mohd. R. Razali

et al.

Reviews in Inorganic Chemistry, Journal Year: 2020, Volume and Issue: 40(4), P. 193 - 232

Published: Aug. 7, 2020

Abstract In wake of emerging applications organotellurium compounds in biological and material science avenues, the current review describes their key synthetic methodologies while focusing synthesis through five ligand-to-metal linkages including carbon; carbon-oxygen; carbon-nitrogen; carbon-metal; carbon-sulfur to tellurium. all these whether tellurium links with ligands a complicated or simple pathways, it is often governed electrophilic substitution reactions. The present study encompasses major routes so as acquire comprehensive understanding compounds.

Language: Английский

Citations

25
Cytotoxicity of asymmetric mononuclear silver(I)-N-heterocyclic carbene complexes against human cervical cancer: Synthesis, crystal structure, DFT calculations and effect of substituents DOI

Nor Farah Hani Md Zin,

S. OOI,

Boon‐Keat Khor

et al.

Journal of Organometallic Chemistry, Journal Year: 2022, Volume and Issue: 976, P. 122439 - 122439

Published: June 27, 2022

Language: Английский

Citations

16
In vitro and in silico anticancer potential of binuclear silver (I) N-heterocyclic carbene (NHCs) complexes: Investigation of interaction with surfactants DOI
Rizwan Ashraf, Sumia Akram, Mohamed El‐Naggar

et al.

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 571, P. 122181 - 122181

Published: June 6, 2024

Language: Английский

Citations

3
Synthesis, characterization and biological evaluation of Bis-benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes DOI
Rana Yasir Nadeem,

Munazzah Yaqoob,

Wan‐Sinn Yam

et al.

Medicinal Chemistry Research, Journal Year: 2022, Volume and Issue: 31(10), P. 1783 - 1791

Published: Aug. 8, 2022

Language: Английский

Citations

12
The first evaluation of the in vitro effects of silver(I)-N-heterocyclic carbene complexes on Encephalitozoon intestinalis and Leishmania major promastigotes DOI Creative Commons
Ahmet Duran Ataş,

Zübeyda Akın-Polat,

Derya Gül Gülpınar

et al.

JBIC Journal of Biological Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 29(5), P. 499 - 509

Published: June 26, 2024

Encephalitozoon intestinalis is an opportunistic microsporidian parasite that primarily infects immunocompromised individuals, such as those with HIV/AIDS or undergoing organ transplantation. Leishmaniasis responsible for parasitic infections, particularly in developing countries. The disease has not been effectively controlled due to the lack of effective vaccine and affordable treatment options. Current options E. infection leishmaniasis are limited often associated adverse side effects. There no previous study literature on antimicrosporidial activities Ag(I)-N-heterocyclic carbene compounds. In this study, vitro previously synthesized complexes were evaluated using spores cultured human renal epithelial cell lines (HEK-293). Inhibition replication was determined by spore counting. addition, effects compounds Leishmania major promastigotes assessed measuring metabolic activity viability a tetrazolium reaction. Statistical analysis performed determine significant differences between treated control groups. Our results showed growth L. inhibited tested concentration-dependent manner. A decrease observed at highest concentrations. These suggest have potential anti-microsporidial anti-leishmanial activity. Further research required elucidate underlying mechanisms action evaluate efficacy animal models clinical trials.

Language: Английский

Citations

2
Synthesis of New Organoselenium Compounds: Characterization and Biological Studies DOI Creative Commons

Nimra Naz,

Saima Saqib,

Rizwan Ashraf

et al.

Macedonian Journal of Chemistry and Chemical Engineering, Journal Year: 2020, Volume and Issue: 39(1), P. 1 - 1

Published: May 30, 2020

Two new organoselenium analogs, (3,3'-(1,2-phenylenebis(methylene))bis(2-selenoxo-2,3-dihydro-1H-imidazole-3,1-diyl))bis(methylene) dibenzoate (III) and 3,3'-(1,2-phenylenebis(methylene))bis(1-benzyl-1H-imidazole-2(3H)-selenone) (V), were derived from newly synthesized organic salts 1,1'-(1,2-phenylenebis(methylene))bis(3-(2-phenoxyacetyl)-1H-imidazol-3-ium) chloride (II) 1,1'-(1,2-phenylenebis(methylene))bis(3-benzyl-1H-imidazol-3-ium) (IV), each was characterized by various analytical techniques, such as Fourier-Transform Infrared Spectroscopy (FT-IR), UV–visible, Nuclear Magnetic Resonance (NMR) spectroscopy, well Ultra-high performance liquid chromatography mass spectrometry/Photodiode array (UHPL-MS/PDA). All compounds tested for their antioxidant anticancer potential. Very good radical scavenging results obtained II IV, with cell viability values of 84.6±3.5 56.7±5.5%, respectively, compared to adducts. products showed significant activity against MCF-7 breast cancer cells, but III better results, 40.5±2.0% 34.4±1.5%, respectively.

Language: Английский

Citations

18
Azolium mediated N Heterocyclic carbene selenium adducts: Synthesis, cytotoxicity and molecular docking studies DOI
Rizwan Ashraf,

Zohra Khalid,

Ayesha Sarfraz

et al.

Journal of Molecular Structure, Journal Year: 2021, Volume and Issue: 1241, P. 130701 - 130701

Published: May 19, 2021

Language: Английский

Citations

15
N-Heterocyclic carbene complexes of Au(I), Ag(I), and Cu(I) as potential anticancer agents: a review DOI
Abdullah Alsalhi

Journal of Coordination Chemistry, Journal Year: 2023, Volume and Issue: 76(7-8), P. 847 - 861

Published: April 18, 2023

The discovery of cisplatin antitumor properties in 1969 encouraged researchers to design metal-based anticancer drugs. Recently, research on N-heterocyclic carbene-based metal complexes was successful due their excellent potency and other biological activities, for example antitubercular, antiviral, anti-ulcerogenic, antifungal, antiglycation antimalarial, anti-inflammatory, antineuropathic, antihypertensive, antioxidant, anti-obesity, antibacterial, analgesic activity. These have even higher than cisplatin. Herein, we summarize the activities carbene (NHC) based Au(I), Ag(I), Cu(I). Further, mechanism action possible structure-activity relationships (SAR) are discussed. We hope this article will help designing highly potent Cu(I)-N-heterocyclic treatment various types cancer.

Language: Английский

Citations

6
Catalytic Behavior of NHC–Silver Complexes in the Carboxylation of Terminal Alkynes with CO2 DOI Creative Commons
Assunta D’Amato, Marco Sirignano,

Francesco Viceconte

et al.

Inorganics, Journal Year: 2024, Volume and Issue: 12(11), P. 283 - 283

Published: Oct. 30, 2024

A number of N-heterocyclic carbene–silver compounds (NHCs)AgX were tested in the direct carboxylation terminal alkynes using carbon dioxide as C1 feedstock. The reactions proceed at a pressure 1 atm CO2 room temperature, presence Cs2CO3, and silver–NHC complexes catalysts. Thus, phenylacetylene several are converted to corresponding propiolic acids good high conversions. activity catalysts is strongly influenced by substituents on NHC backbone nature counterion. Specifically, most active compound exhibits iodide counterion stabilized benzimidazole derivative. After 24 h reaction, quantitative conversion obtained utilizing DMF solvent substrate.

Language: Английский

Citations

2
Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies DOI
Serap Şahin‐Bölükbaşı, Pakize Cantürk, Ozan Kılıçkaya

et al.

Drug Development Research, Journal Year: 2021, Volume and Issue: 82(7), P. 907 - 926

Published: May 12, 2021

Abstract Because of the continuous need for efficient therapeutic agents against various kinds cancers and infectious diseases, pharmaceutical industry has to find new candidates strategies develop novel drugs. They increasingly use computational tools in R&D stages screening extensive sets drug before starting pre‐clinical clinical trials. N‐Heterocyclic carbenes (NHCs) can be evaluated as good because they offer both anti‐cancer anti‐inflammatory features with their general low‐toxicity profiles. To date, different NHCs (Cu, Co, Ni, Au, Ag, Ru, etc.) have been synthesized uses shown. Here, we reviewed recent studies focused on Ag(I)‐NHC complexes activities. Also, existing examples usage density functional theory structure–activity relationship evaluated.

Language: Английский

Citations

14