ACS Omega,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 7, 2024
Sutures
are
a
crucial
component
of
surgical
procedures,
serving
to
close
and
stabilize
wound
margins
promote
healing.
However,
microbial
contamination
sutures
can
increase
the
risk
site
infections
(SSI)
due
colonization
by
pathogens.
This
study
aimed
tackle
SSI
synthesizing
positively
charged
silver
nanoparticles
(P-AgNPs)
using
them
produce
antimicrobial
sutures.
The
P-AgNPs
were
reduced
stabilized
polyethylenimine
(PEI),
cationic
branched
polymer.
physiochemical
characteristics
confirmed
from
surface
plasmon
resonance
(SPR)
peak
at
419
nm,
spherical
morphology
with
particle
size
range
8–10
PEI
functional
groups
on
NPs,
hydrodynamic
diameter
12.3
±
2.4
zeta
potential
31.3
6
mV.
Subsequently,
surfaces
silk
impregnated
different
time
intervals
(24,
48,
96
h)
an
ex
situ
method.
Scanning
electron
microscopy
(SEM)
tensile
strength
studies
conducted
determine
coating
durability
NP-coated
NPs
quantified
inductively
coupled
plasma
optical
emission
spectrophotometry
(ICP-OES),
which
was
in
1–5
μg.
Primarily,
activity
studied
three
microorganisms
(Candida
albicans,
Streptococcus
mutans,
Staphylococcus
aureus)
for
both
suture-coated
agar
diffusion
results
showed
that
only
exhibited
enhanced
effects
against
bacteria
fungi.
Finally,
cytotoxicity
investigated
stem
cells
apical
papilla
(SCAPs)
24
h,
more
than
75%
cell
viability.
Overall,
indicate
potentially
be
used
as
diminish
or
inhibit
postoperative
general
surgery
patients.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1332 - 1332
Published: Oct. 16, 2024
The
remarkable
versatility
of
gold
nanoparticles
(AuNPs)
makes
them
innovative
agents
across
various
fields,
including
drug
delivery,
biosensing,
catalysis,
bioimaging,
and
vaccine
development.
This
paper
provides
a
detailed
review
the
important
role
AuNPs
in
delivery
therapeutics.
We
begin
by
exploring
traditional
systems
(DDS),
highlighting
revolutionizing
techniques.
then
describe
unique
intriguing
properties
that
make
exceptional
for
delivery.
Their
shapes,
functionalization,
drug-loading
bonds,
targeting
mechanisms,
release
therapeutic
effects,
cellular
uptake
methods
are
discussed,
along
with
relevant
examples
from
literature.
Lastly,
we
present
applications
medical
domains,
cancer,
cardiovascular
diseases,
ocular
diabetes,
focus
on
vitro
vivo
cancer
research.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 13, 2025
The
spent
black
tea
extract
was
utilized
in
order
to
synthesize
the
silver
nanoparticles
(SBT-AgNPs).
Various
parameters
were
tested
yield
best
production
of
SBT-AgNPs.
characterization
conducted
by
X-Ray
diffraction,
Scanning
electron
microscopy,
Zeta
potential
and
energy
dispersive
X-ray
(EDX).
XRD
analysis
showed
hkl
planes
corresponding
(111),
(200),
(220),
(311)
at
2θ
theta
deg
38.3°,
40.8°,
64.5°,
74.2°.
scanning
microscopy
reported
plate
like
round
shaped
morphology
AgNPs.
zeta
examined
be
-17.5
mV
a
size
distribution
intensity
157.6
d.
nm
observed.
EDX
employed
determine
purity
samples
reporting
strong
peak
(Ag).
degradation
activity
photocatalytic
removal
methylene
blue
malachite
green
dyes
from
textile
wastewater.
wastewater
decrease
25%
58.3%.
also
reduced
33.3%
60%,
which
remarkably
significant
owing
presence
complex
factor
natural
environment.
study
sets
promising
record
harbor
full
available
food
waste
resource,
such
as
form
SBT-AgNPs
its
application
dye
waste.
multifaceted
outcomes
this
resulted
an
eco-friendly
procedure,
thereby
reusing
material
for
environmental
cleanup.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 266 - 266
Published: Feb. 11, 2025
Methicillin-resistant
Staphylococcus
aureus
(MRSA)
continues
to
represent
a
significant
clinical
challenge,
characterized
by
consistently
elevated
rates
of
morbidity
and
mortality.
Care
regimen
success
is
still
difficult
necessitates
assessing
new
antibiotics
as
well
supplemental
services,
including
source
control
searching
for
alternative
approaches
combating
it.
Hence,
we
propose
synthesize
silver
nanoparticles
(Ag-NPs)
employing
cell-free
filter
(CFF)
Streptomyces
sp.
augment
antibiotic
activity
combat
biofilm-forming
MRSA.
Seven
bacterial
isolates
from
samples
were
identified,
profiled
with
Vitek-2,
the
phenotypic
detecting
biofilm
Congo
red
medium
microplate
assay
was
carried
out.
The
PCR
technique
used
genes
(icaA
icaD)
coded
in
forming.
characterization
Ag-NPs
performed
using
several
analytical
methods,
such
UV
spectroscopy,
dynamic
light
scattering
(DLS),
zeta
potential
measurement,
transmission
electron
microscopy
(TEM),
X-ray
diffraction
(XRD),
Fourier
transform
infrared
spectroscopy
(FTIR).
antibacterial
properties
oxacillin-Ag-NPs
assessed
against
standard
strains
agar
diffusion
microdilution
assay.
biogenic
synthesis
resulted
uniformly
spherical
particles,
an
average
size
20
nm.
These
demonstrated
MRSA,
minimum
inhibitory
concentrations
(MICs)
ranging
12
15
μg/mL.
Additionally,
completely
impede
formation
MRSA
at
sublethal
doses
0.75
MICs.
expression
levels
icaA
icaD
reduced
1.9-
2.2-
2.4-
2.8-fold,
respectively.
A
synergistic
effect
noted
when
combination
oxacillin,
leading
MICs
1.87
μg/mL
oxacillin
4.0
FICi
0.375
further
validated
relationship
between
4
Findings
time-kill
test
highest
reduction
log10
(CFU)/mL
initial
inoculum
after
12-hour
exposure.
cytotoxicity
analysis
revealed
no
cytotoxic
effects
on
human
skin
cell
line
HFB-4
low
concentrations,
IC50
values
61.40
µg/mL
34.2
HepG-2.
Comparable
oxacillin-Ag-NPs,
showed
different
exhibited
value
31.2
HepG-2-cells.
In
conclusion,
biosynthesis
has
effective
hindered
formation,
suggesting
valuable
applications.
Plasmonics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 4, 2024
Abstract
Localized
surface
plasmon
resonance
(LSPR)
is
a
nanoscale
phenomenon
associated
with
noble
metal
nanostructures
that
has
long
been
studied
and
gained
considerable
interest
in
recent
years.
These
resonances
produce
sharp
spectral
absorption
scattering
peaks,
along
strong
electromagnetic
near-field
enhancements.
Over
the
past
decade,
advancements
fabrication
of
have
propelled
significant
developments
various
scientific
technological
aspects
LSPR.
One
notable
application
detection
molecular
interactions
near
nanoparticle
surface,
observable
through
shifts
LSPR
peak.
This
document
provides
an
overview
this
sensing
strategy.
Given
broad
expanding
scope
topic,
it
impossible
to
cover
every
aspect
comprehensively
review.
However,
we
aim
outline
major
research
efforts
within
field
review
diverse
array
relevant
literature.
We
will
provide
detailed
summary
physical
principles
underlying
address
some
existing
inconsistencies
nomenclature
used.
Our
discussion
primarily
focus
on
sensors
employ
nanoparticles,
rather
than
those
utilizing
extended,
fabricated
structures.
concentrate
where
acts
as
primary
mode
signal
transduction,
excluding
hybrid
strategies
like
combining
fluorescence.
Additionally,
our
examination
biological
largely
pertain
label-free
methods,
use
nanoparticles
labels
or
means
enhance
efficacy
label.
In
subsequent
section
review,
delve
into
analytical
theory
underpinning
LSPR,
exploring
its
origins
dependency
material
properties
metals
surrounding
refractive
index.
discuss
behavior
both
spherical
spheroidal
particles
elaborate
how
response
varies
particle
ratio.
Further,
detail
fundamentals
nanoparticle-based
sensing.
includes
exploration
single-particle
ensemble
measurements
comparative
analysis
scattering,
absorption,
extinction
phenomena.
The
extend
these
are
applied
practical
scenarios,
highlighting
key
experimental
approaches
measurement
techniques.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(14), P. e34564 - e34564
Published: July 1, 2024
The
aim
of
this
study
was
to
systematically
review
the
literature
investigate
whether
silver
nanoparticles
(AgNPs)
have
an
anti-inflammatory
effect
in
vivo.
guidelines
PRISMA
were
applied,
and
a
registration
made
PROSPERO.
A
personalized
search
PubMed,
Web
Science,
Scopus,
Embase,
Lilacs,
Google
Scholar
databases
conducted
September
2023.
For
data
analysis,
inverse
variance
random
effects
model
used.
tools
SYRCLE
GRADE
used
assess
risk
bias
certainty
evidence,
respectively.
From
9185
identified
studies,
5685
duplicate
studies
excluded;
52
read
full
text,
7
included
review.
Six
evaluated
by
meta-analysis,
increase
molecules
(SMD
-5.22;
PI
[-6.50,
−3.94])
ones
5.75;
[3.79,
7.72])
observed.
Qualitative
analysis
showed
reduction
pro-inflammatory
proteins
COX-2
pathway.
It
concluded
that
AgNPs
present
action
vivo
through
mechanisms
involving
proteins,
molecules,
selective
inhibition
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 70 - 70
Published: Jan. 7, 2025
Malignant
growth
is
expected
to
surpass
other
significant
causes
of
death
as
one
the
top
reasons
for
dismalness
and
mortality
worldwide.
According
a
World
Health
Organization
(WHO)
study,
this
illness
approximately
between
9
10
million
instances
deaths
annually.
Chemotherapy,
radiation,
surgery
are
three
main
methods
treating
cancer.
These
seek
completely
eradicate
all
cancer
cells
while
having
fewest
possible
unintended
impacts
on
healthy
cell
types.
Owing
lack
target
selectivity,
majority
medications
have
substantial
side
effects.
On
hand,
nanomaterials
transformed
identification,
diagnosis,
management
Nanostructures
with
biomimetic
properties
been
grown
late,
fully
intent
observing
sickness.
nanostructures
be
consumed
by
in
areas
profound
disease.
Furthermore,
because
their
extraordinary
physicochemical
properties,
which
incorporate
nanoscale
aspects,
more
prominent
surface
region,
explicit
geometrical
features,
ability
embody
different
substances
within
or
outside
surfaces,
remarkable
nano-vehicles
conveying
restorative
specialists
designated
regions.
This
review
discusses
recent
developments
nanostructured
materials
such
graphene,
dendrimers,
cell-penetrating
peptide
nanoparticles,
nanoliposomes,
lipid
magnetic
nano-omics
diagnosis
Discover Nano,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 23, 2025
Diabetic
wounds
with
chronic
infections
present
a
significant
challenge,
exacerbated
by
the
growing
issue
of
antimicrobial
resistance,
which
often
leads
to
delayed
healing
and
increased
morbidity.
This
study
introduces
novel
silver-zinc
oxide-eugenol
(Ag+ZnO+EU)
nanocomposite,
specifically
designed
enhance
activity
promote
wound
healing.
The
nanocomposite
was
thoroughly
characterized
using
advanced
analytical
techniques,
confirming
its
nanoscale
structure,
stability
chemical
composition.
Ag+ZnO+EU
demonstrated
potent
efficacy
against
range
associated
pathogens,
including
standard
clinical
isolates
Staphylococcus
aureus,
Pseudomonas
aeruginosa
Candida
albicans.
Minimum
inhibitory
concentrations
for
were
significantly
lower
than
those
individual
components,
highlighting
synergistic
effect
nanocomposite.
Time-kill
assays
revealed
rapid
microbial
eradication,
achieving
complete
sterility
within
240-min.
Importantly,
effectively
eliminated
persister-like
cells,
are
typically
resistant
conventional
treatments,
suggesting
potential
solution
persistent
infections.
In
vitro
scratch
human
keratinocyte
cells
that
accelerated
closure,
near-complete
observed
24-h,
indicating
enhanced
cell
migration
tissue
regeneration.
Additionally,
showed
antidiabetic
effects
increasing
glucose
uptake
up
97.21%
in
an
assay
2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)
amino]-2-deoxy-D-glucose,
fluorescent
analog,
applications
beyond
These
findings
highlight
as
promising
candidate
addressing
both
resistance
impaired
diabetic
contexts.