Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1332 - 1332

Published: Oct. 16, 2024

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.

Language: Английский

---

Emerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 70 - 70

Published: Jan. 7, 2025

Malignant growth is expected to surpass other significant causes of death as one the top reasons for dismalness and mortality worldwide. According a World Health Organization (WHO) study, this illness approximately between 9 10 million instances deaths annually. Chemotherapy, radiation, surgery are three main methods treating cancer. These seek completely eradicate all cancer cells while having fewest possible unintended impacts on healthy cell types. Owing lack target selectivity, majority medications have substantial side effects. On hand, nanomaterials transformed identification, diagnosis, management Nanostructures with biomimetic properties been grown late, fully intent observing sickness. nanostructures be consumed by in areas profound disease. Furthermore, because their extraordinary physicochemical properties, which incorporate nanoscale aspects, more prominent surface region, explicit geometrical features, ability embody different substances within or outside surfaces, remarkable nano-vehicles conveying restorative specialists designated regions. This review discusses recent developments nanostructured materials such graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid magnetic nano-omics diagnosis

Language: Английский

---

Photocatalytic removal of textile wastewater-originated methylene blue and malachite green dyes using spent black tea extract-coated silver nanoparticles

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 13, 2025

The spent black tea extract was utilized in order to synthesize the silver nanoparticles (SBT-AgNPs). Various parameters were tested yield best production of SBT-AgNPs. characterization conducted by X-Ray diffraction, Scanning electron microscopy, Zeta potential and energy dispersive X-ray (EDX). XRD analysis showed hkl planes corresponding (111), (200), (220), (311) at 2θ theta deg 38.3°, 40.8°, 64.5°, 74.2°. scanning microscopy reported plate like round shaped morphology AgNPs. zeta examined be -17.5 mV a size distribution intensity 157.6 d. nm observed. EDX employed determine purity samples reporting strong peak (Ag). degradation activity photocatalytic removal methylene blue malachite green dyes from textile wastewater. wastewater decrease 25% 58.3%. also reduced 33.3% 60%, which remarkably significant owing presence complex factor natural environment. study sets promising record harbor full available food waste resource, such as form SBT-AgNPs its application dye waste. multifaceted outcomes this resulted an eco-friendly procedure, thereby reusing material for environmental cleanup.

Language: Английский

---

Impeding Biofilm-Forming Mediated Methicillin-Resistant Staphylococcus aureus and Virulence Genes Using a Biosynthesized Silver Nanoparticles–Antibiotic Combination

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 266 - 266

Published: Feb. 11, 2025

Methicillin-resistant Staphylococcus aureus (MRSA) continues to represent a significant clinical challenge, characterized by consistently elevated rates of morbidity and mortality. Care regimen success is still difficult necessitates assessing new antibiotics as well supplemental services, including source control searching for alternative approaches combating it. Hence, we propose synthesize silver nanoparticles (Ag-NPs) employing cell-free filter (CFF) Streptomyces sp. augment antibiotic activity combat biofilm-forming MRSA. Seven bacterial isolates from samples were identified, profiled with Vitek-2, the phenotypic detecting biofilm Congo red medium microplate assay was carried out. The PCR technique used genes (icaA icaD) coded in forming. characterization Ag-NPs performed using several analytical methods, such UV spectroscopy, dynamic light scattering (DLS), zeta potential measurement, transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR). antibacterial properties oxacillin-Ag-NPs assessed against standard strains agar diffusion microdilution assay. biogenic synthesis resulted uniformly spherical particles, an average size 20 nm. These demonstrated MRSA, minimum inhibitory concentrations (MICs) ranging 12 15 μg/mL. Additionally, completely impede formation MRSA at sublethal doses 0.75 MICs. expression levels icaA icaD reduced 1.9- 2.2- 2.4- 2.8-fold, respectively. A synergistic effect noted when combination oxacillin, leading MICs 1.87 μg/mL oxacillin 4.0 FICi 0.375 further validated relationship between 4 Findings time-kill test highest reduction log10 (CFU)/mL initial inoculum after 12-hour exposure. cytotoxicity analysis revealed no cytotoxic effects on human skin cell line HFB-4 low concentrations, IC50 values 61.40 µg/mL 34.2 HepG-2. Comparable oxacillin-Ag-NPs, showed different exhibited value 31.2 HepG-2-cells. In conclusion, biosynthesis has effective hindered formation, suggesting valuable applications.

Language: Английский

---

Sustainable green synthesis of silver nanoparticles for safer biomedical application

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115998 - 115998

Published: Feb. 1, 2025

Language: Английский

---

Developments in Localized Surface Plasmon Resonance

Plasmonics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Localized surface plasmon resonance (LSPR) is a nanoscale phenomenon associated with noble metal nanostructures that has long been studied and gained considerable interest in recent years. These resonances produce sharp spectral absorption scattering peaks, along strong electromagnetic near-field enhancements. Over the past decade, advancements fabrication of have propelled significant developments various scientific technological aspects LSPR. One notable application detection molecular interactions near nanoparticle surface, observable through shifts LSPR peak. This document provides an overview this sensing strategy. Given broad expanding scope topic, it impossible to cover every aspect comprehensively review. However, we aim outline major research efforts within field review diverse array relevant literature. We will provide detailed summary physical principles underlying address some existing inconsistencies nomenclature used. Our discussion primarily focus on sensors employ nanoparticles, rather than those utilizing extended, fabricated structures. concentrate where acts as primary mode signal transduction, excluding hybrid strategies like combining fluorescence. Additionally, our examination biological largely pertain label-free methods, use nanoparticles labels or means enhance efficacy label. In subsequent section review, delve into analytical theory underpinning LSPR, exploring its origins dependency material properties metals surrounding refractive index. discuss behavior both spherical spheroidal particles elaborate how response varies particle ratio. Further, detail fundamentals nanoparticle-based sensing. includes exploration single-particle ensemble measurements comparative analysis scattering, absorption, extinction phenomena. The extend these are applied practical scenarios, highlighting key experimental approaches measurement techniques.

Language: Английский

---

Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34564 - e34564

Published: July 1, 2024

The aim of this study was to systematically review the literature investigate whether silver nanoparticles (AgNPs) have an anti-inflammatory effect in vivo. guidelines PRISMA were applied, and a registration made PROSPERO. A personalized search PubMed, Web Science, Scopus, Embase, Lilacs, Google Scholar databases conducted September 2023. For data analysis, inverse variance random effects model used. tools SYRCLE GRADE used assess risk bias certainty evidence, respectively. From 9185 identified studies, 5685 duplicate studies excluded; 52 read full text, 7 included review. Six evaluated by meta-analysis, increase molecules (SMD -5.22; PI [-6.50, −3.94]) ones 5.75; [3.79, 7.72]) observed. Qualitative analysis showed reduction pro-inflammatory proteins COX-2 pathway. It concluded that AgNPs present action vivo through mechanisms involving proteins, molecules, selective inhibition

Language: Английский

---

Fioria vitifolia-mediated silver nanoparticles: Eco-friendly synthesis and biomedical potential

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 66, P. 106020 - 106020

Published: Aug. 23, 2024

Language: Английский

---

Facile green synthesis of novel AgNPs using Hyoscyamus leaf extract as capping agent: Characterization and their potential antibacterial activities

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: 173, P. 113893 - 113893

Published: Jan. 5, 2025

Language: Английский

---

In vitro evaluation of silver-zinc oxide-eugenol nanocomposite for enhanced antimicrobial and wound healing applications in diabetic conditions

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 23, 2025

Diabetic wounds with chronic infections present a significant challenge, exacerbated by the growing issue of antimicrobial resistance, which often leads to delayed healing and increased morbidity. This study introduces novel silver-zinc oxide-eugenol (Ag+ZnO+EU) nanocomposite, specifically designed enhance activity promote wound healing. The nanocomposite was thoroughly characterized using advanced analytical techniques, confirming its nanoscale structure, stability chemical composition. Ag+ZnO+EU demonstrated potent efficacy against range associated pathogens, including standard clinical isolates Staphylococcus aureus, Pseudomonas aeruginosa Candida albicans. Minimum inhibitory concentrations for were significantly lower than those individual components, highlighting synergistic effect nanocomposite. Time-kill assays revealed rapid microbial eradication, achieving complete sterility within 240-min. Importantly, effectively eliminated persister-like cells, are typically resistant conventional treatments, suggesting potential solution persistent infections. In vitro scratch human keratinocyte cells that accelerated closure, near-complete observed 24-h, indicating enhanced cell migration tissue regeneration. Additionally, showed antidiabetic effects increasing glucose uptake up 97.21% in an assay 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-D-glucose, fluorescent analog, applications beyond These findings highlight as promising candidate addressing both resistance impaired diabetic contexts.

Language: Английский

---